MHC

OVA Peptide (323-339) is an immunodominant epitope peptide derived from chicken ovalbumin (OVA), which is the major MHC class II-restricted T-cell epitope that specifically binds H2-IAd molecules, and a B-cell epitope that is recognized by IgE antibodies. It is commonly used in the study of egg allergy, and is able to induce strong Th2-type immune responses and IgE antibody production in mice.

OVA Peptide(257-264) is an ovalbumin octamer Peptide expressed by class I MHC molecule h-2kb.

Decamethylene glycol is a substance used as a reagent in the biological study of modified oligonucleotide with in vivo antitumoral activity. Also used in the pharmaceutical study on the composition of essential oils obtained from myrrh and frankincense an

OVA Peptide (257-264) TFA, an octameric peptide epitope from ovalbumin, is presented by the class I MHC molecule, H-2Kb, showcasing a class I (Kb)-restricted profile.

GAD65 (206-220) is a synthetic peptide derived from glutamic acid decarboxylase (GAD) 65, specifically corresponding to residues 180-188. It is known that GAD65 interacts with I-Ag7 MHC class II molecules and is a significant pancreatic antigen that self-reactive T cells target in type I diabetes mellitus.

SIIVFEKL TFA is a variant of the principal MHC class I-restricted epitope, SIINFEKL. This antigenic peptide stimulates specific T cells in experimental settings to study competitive interactions among T cells. SIIVFEKL TFA exhibits lower affinity for the OT-I T cell receptor (TCR) and can be utilized to detect CD8+ T cells.

Isuventatug is a monoclonal antibody that targets human MICA (MHC I chain-related molecule A) and MICB (MHC I chain-related molecule B). By binding to MICA and MICB, Isuventatug modulates the interaction between immune cells and tumor cells, exhibiting anti-tumor activity. This compound holds potential for research in cancer immunotherapy.

OVA Peptide(257-264) acetate salt is a Class I (Kb)-restricted epitope of OVA. This octamer peptide is presented by Class I MHC molecule H-2Kb derived from ovalbumin.

Ovalbumin (OVA) peptide, primarily found in egg white, is a class I (Kb)-restricted peptide epitope presented by H-2Kb, the mouse MHC (major histocompatibility complex) class I gene product. It has garnered significant attention in the field of allergy research [1] [2].

IRBP (1-20), human is the 1-20 fragment of interphotoreceptor retinoid binding protein (IRBP).This peptide is a 1 to 20 amino acid fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP is a 140-kDa glycolipoprotein residing in the inter

Smcy HY Peptide (738-746) is an H2-Db-restricted peptide derived from amino acids 738 to 746 of the Smcy protein.

Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) is an IgG2a, κ antibody inhibitor derived from mice that targets monkey or human MHC class II.

The M133 peptide is a coronavirus-specific CD4 T cell epitope. In mice infected with the neurotropic coronavirus (strain JHM of mouse hepatitis virus), the M133 peptide demonstrates immunodominance. It activates CD4 T cells by forming an MHC/peptide complex through binding with MHC II molecules, which is recognized by specific TCRs.

Anti-Rat β-2-Microglobulin Antibody (4C9) is an IgG1 antibody inhibitor derived from mice, targeting rat β-2-Microglobulin.

CMV pp65(13-27) is a bioactive peptide derived from the 65k lower matrix phosphoprotein of the human cytomegalovirus, specifically comprising amino acid residues 13 to 27, including a nine-amino-acid sequence (LGPISGHVL) that corresponds to the consensus binding motif for the major histocompatibility complex H2-Dd T-cell epitope.

Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) is an IgG2a, κ antibody inhibitor derived from mice, designed to target MHC Class II in both mice and rats.

MOG (35-55), human, a constituent of central nervous system myelin, is distinguishable from mMOG (35-55) due to a proline-to-serine substitution at position 42. It possesses immunogenic properties and is partially cross-reactive with mMOG35–55. However, MOG (35-55), human does not induce encephalitogenic effects, and only elicits minimal clinical signs of EAE (experimental autoimmune encephalomyelitis) in comparison to the rodent peptide.

KSPWFTTL is an immunodominant epitope derived from the p15E transmembrane protein. It is Kb-restricted and can enhance the susceptibility of a tumor cell line to cytotoxic T lymphocytes targeting anti-AKR/Gross MuLV.

MOG (89-113), human is a peptide fragment of human myelin oligodendrocyte glycoprotein.

Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse (MOG (40-54)) is a self-antigenic epitope associated with the CD8 class of proteins within the MOG protein, presented in conjunction with H-2Db [1].

InsB (9-23) (InsulinB chain (9-23)) is an insulin B chain peptide capable of binding to the class II major histocompatibility complex (MHC) allele I-Ag7. It holds potential for research into various autoimmune diseases, including type 1 diabetes.

H2-D b restricted epitopesVSVNucleoprotein (52-59) is a nonapeptide derived from the nucleoprotein of Vesicular Stomatitis Virus (VSV). It binds to MHC class I molecules to present itself to CD8+ T cells, thereby activating cytotoxic T lymphocytes (CTLs) that recognize and destroy cells expressing the corresponding antigen. This epitope is instrumental in the development of CTL vaccines against the Ebola virus.

Cholic acid 7-sulfate is a metabolite of the primary bile acid cholic acid.[1],[2] It is produced by conjugation of a sulfate group with the hydroxy group at position 7 of cholic acid in the liver and gut. Fecal levels of cholic acid 7-sulfate are increased in male, but not female, mice fed a diet supplemented with cholic acid or chenodeoxycholic acid.[2]

TYVPANASL TFA, a nine-amino-acid MHC I-binding CD8 T-cell epitope derived from HER2/neu, is utilized in the formulation of J-LEAPS vaccines [1].