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Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

MHC

Major Histocompatibility Complex (MHC) is a group of genes that encode cell surface proteins that are critical to the immune system's ability to present antigens.MHC molecules bind to peptide fragments from pathogens and present them on the cell surface where they can be recognised by T-cells thereby initiating an immune response.There are three main classes of MHC molecules: Class I, Class II and Class III.

Filter HomeSignaling PathwaysImmunology/InflammationMHC

OVA Peptide (323-339)

T7800092915-79-2

OVA Peptide (323-339) is an immunodominant epitope peptide derived from chicken ovalbumin (OVA), which is the major MHC class II-restricted T-cell epitope that specifically binds H2-IAd molecules, and a B-cell epitope that is recognized by IgE antibodies. It is commonly used in the study of egg allergy, and is able to induce strong Th2-type immune responses and IgE antibody production in mice.

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Isuventatug

T9901A-9082986317-23-9

Isuventatug is a monoclonal antibody that targets human MICA (MHC I chain-related molecule A) and MICB (MHC I chain-related molecule B). By binding to MICA and MICB, Isuventatug modulates the interaction between immune cells and tumor cells, exhibiting anti-tumor activity. This compound holds potential for research in cancer immunotherapy.

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OVA Peptide(257-264) acetate salt

TP3336

OVA Peptide(257-264) acetate salt is a Class I (Kb)-restricted epitope of OVA. This octamer peptide is presented by Class I MHC molecule H-2Kb derived from ovalbumin.

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M133 peptide

TP3623

The M133 peptide is a coronavirus-specific CD4 T cell epitope. In mice infected with the neurotropic coronavirus (strain JHM of mouse hepatitis virus), the M133 peptide demonstrates immunodominance. It activates CD4 T cells by forming an MHC/peptide complex through binding with MHC II molecules, which is recognized by specific TCRs.

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Anti-Rat β-2-Microglobulin Antibody (4C9)

T9901A-1128

Anti-Rat β-2-Microglobulin Antibody (4C9) is an IgG1 antibody inhibitor derived from mice, targeting rat β-2-Microglobulin.

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Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S)

T9901A-1197

Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) is an IgG2a, κ antibody inhibitor derived from mice, designed to target MHC Class II in both mice and rats.

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InsB (9-23)

TP3339163364-16-7

InsB (9-23) (InsulinB chain (9-23)) is an insulin B chain peptide capable of binding to the class II major histocompatibility complex (MHC) allele I-Ag7. It holds potential for research into various autoimmune diseases, including type 1 diabetes.

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H2-D b restricted epitopes VSV Nucleoprotein (52-59)

TP3613132326-74-0

H2-D b restricted epitopesVSVNucleoprotein (52-59) is a nonapeptide derived from the nucleoprotein of Vesicular Stomatitis Virus (VSV). It binds to MHC class I molecules to present itself to CD8+ T cells, thereby activating cytotoxic T lymphocytes (CTLs) that recognize and destroy cells expressing the corresponding antigen. This epitope is instrumental in the development of CTL vaccines against the Ebola virus.

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Anti-Mouse MHC Class II (βchain) Antibody (KL277)

T9901A-1157

Anti-Mouse MHC Class II (β chain) Antibody (KL277) is an IgG antibody inhibitor sourced from hamster or mouse and targets mouse MHC Class II.

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