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breast

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    1086
    TargetMol | Inhibitors_Agonists
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    TargetMol | Inhibitors_Agonists
Eribulin mesylate
ER-086526 mesylate, E7389 mesylate, B1939 mesylate
T13687441045-17-6
Eribulin mesylate (E7389 mesylate) (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used in the treatment of metastatic breast cancer.
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TargetMol | Inhibitor Hot
Alpelisib
BYL-719
T19211217486-61-7
Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity, inhibiting PI3Kβ γ δ with low activity (IC50=250 290 1200 nM). Alpelisib demonstrates antitumor activity and specifically targets PIK3CA mutant tumors.
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TargetMol | Inhibitor Hot
MK-2206 dihydrochloride
MK-2206 2HCl
T19521032350-13-2
MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8 12 65 nM) with orally active, highly potent and selective potency. MK-2206 dihydrochloride exhibits antitumor activity.
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TargetMol | Inhibitor Hot
Formononetin
Formononetol, Flavosil, Biochanin B
T0724485-72-3
Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.
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2-Phenylglycine
DL-α-Phenylglycine
T134852835-06-5
2-Phenylglycine (DL-α-Phenylglycine) is a metabolite present in breast milk during lactation.
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4-Vinylphenol
T135092628-17-3
4-Vinylphenol is the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine found in Hedyotis diffusa Willd. 4-Vinylphenol induces apoptosis in vivo.
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7-10 days
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Dasatinib
BMS-354825
T1448302962-49-8
Dasatinib (BMS-354825) is an orally active, ATP-competitive tyrosine kinase inhibitor that targets Src and Bcr-Abl (Ki=16 30 pM), with antitumor activity, used in the treatment of leukemia and lymphoma.
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Dasatinib monohydrate
BMS-354825 Monohydrate
T1448L863127-77-9
Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activities of these kinases. Apparently, because of its less stringent binding affinity for the BCR-ABL kinase, Dasatinib monohydrate has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations.
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Letrozole
CGS 20267
T1590112809-51-5
Letrozole (CGS 20267) is an Aromatase Inhibitor. The mechanism of action of letrozole is as an Aromatase Inhibitor.
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Niraparib
MK-4827
T32311038915-60-4
Niraparib (MK-4827) is a PARP inhibitor that selectively targets PARP1 and PARP2 (IC50=3.8 2.1 nM), exhibiting antitumor activity, inhibiting DNA damage repair, and inducing apoptosis.
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Niraparib tosylate monohyrate
T94971613220-15-7
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.
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Curcumol
(-)-Curcumol
T28534871-97-0
Curcumol ((-)-Curcumol), a pure monomer derived from Rhizoma Curcumaeis, exhibits antitumor activities.
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666-15
CREB inhibitor
T53181433286-70-4
666-15 is a selective CREB inhibitor with an IC50 of 81 nM. 666-15 can effectively inhibit the growth of breast cancer.
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TargetMol | Inhibitor Hot
telaglenastat
CB-839, CB839, CB 839
T67971439399-58-2
Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.
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BOS-172722
T147651578245-44-9
BOS-172722 is an inhibitor of the monopolar spindle 1 (MPS1) checkpoint with an IC50 of 2 nM.
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AZ9482
T222641825345-33-2
AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells.
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Niraparib hydrochloride
MK-4827 hydrochloride, MK-4827 (hydrochloride)
T33531038915-64-8
Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. By inhibiting PARP activity, niraparib hydrochloride increases DNA strand breaks, leading to genomic instability and apoptosis. The PARP family of proteins detects and repairs single-strand DNA breaks via the base-excision repair (BER) pathway.
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Estrone sulfate sodium
Estrone 3-sulfate (sodium salt), 17β-Estrone 3-sulfate
T36857438-67-5
Estrone sulfate sodium (17β-Estrone 3-sulfate) is an endogenous steroid and an estrogen ester that is biologically inactive. It is converted by steroid sulfatase into estrone . Estrone sulfate sodium has been investigated as a ligand for targeting organic anion transporting polypeptides f
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7-10 days
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Xanthatin
T3S015326791-73-1
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell proliferation possibly associated wit
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Goserelin acetate
Zoladex, ICI-118630 acetate, Fertilan
T4102145781-92-6
Goserelin acetate (Fertilan) is a synthetic long-acting agonist of gonadotropin-releasing hormone, used in treatments of cancer.
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Obtusifolin
T4S0969477-85-0
1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be a novel anti-breast-cancer bone me
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LLY-507
LLY507, LLY 507
T68791793053-37-8
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.
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Niraparib tosylate
Niraparib (MK-4827) tosylate, MK-4827 (tosylate), MK 4827 tosylate
T68921038915-73-9
Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM 2.1 nM) is a selective PARP1 PARP2 inhibitor.
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Proscillaridin A
TN2105466-06-8
Proscillaridin A is a natural product.It is a potent poison of topoisomerase I II activity with IC50 values of 30 nM and 100 nM, respectively.
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7-10 days
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