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Results for "

caspase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    499
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    2
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    54
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    57
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    TargetMol | Activity
Z-IETD-FMK
T7019210344-98-2
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a cell-permeable, selective inhibitor of caspase 8.
  • $127
In Stock
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TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Boc-Asp(OMe)-fluoromethyl ketone
T39308187389-53-3In house
Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) is a broad range caspase inhibitor. Boc-Asp(OME)-Fluoromethyl Ketone inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.
  • $34
In Stock
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TargetMol | Inhibitor Sale
Ac-YVAD-AOM
T78631154674-81-4
Ac-YVAD-AOM is a selective and potent caspase-1 inhibitor showing antitumor activity and potential analgesic activity.
  • $105
In Stock
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QTY
Z-YVAD-FMK
TP1466210344-97-1
AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.
  • $182
In Stock
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TargetMol | Citations Cited
Ac-DEVD-AMC
T18909169332-61-0
Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .
  • $43
In Stock
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TargetMol | Inhibitor Sale
Boc-AEVD-CHO
T80467220094-15-5
Boc-AEVD-CHO, a selective Caspase 8 inhibitor, facilitates apoptosis research and the investigation of immune and inflammatory diseases [1] [2].
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Ac-AAVALLPAVLLALLAP-YVAD-CHO
T80532201608-12-0
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1 exhibiting antitumor activity [1].
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Ac-DNLD-CHO
T83205775289-20-8
Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is an inhibitor of Caspase-3 7, with IC50 values of 9.89 nM and 245 nM, and approximate Ki values of 0.68 nM and 55.7 nM, respectively. This compound is utilized in the study of diseases associated with caspase-mediated apoptosis, including neurodegenerative and viral infection diseases [1].
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Ac-AAVALLPAVLLALLAP-LEVD-CHO
T80536886462-82-4
Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-permeable caspase-4 inhibitor with demonstrated antitumor activity [1].
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Ac-YVAD-CHO
T19883143313-51-3
Ac-YVAD-CHO (L 709049) is a selective and potent tetrapeptide interleukin 1β-converting enzyme (ICE) and caspase-1 (ICE)-like protease inhibitor with anti-inflammatory activity, inhibits cancer cell growth, and inhibits the production of mature IL-lβ. Ac-YVAD-CHO attenuates quinolinic acid-induced p53 increase and apoptosis in rat striatum.
  • $130
In Stock
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IETD-CHO TFA
T80093
IETD-CHO TFA (Caspase-8-IN-1) functions as a potent inhibitor of caspase-8 [1].
  • Inquiry Price
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Ac-AAVALLPAVLLALLAP-DEVD-CHO
T80531201608-15-3
Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible inhibitor of caspase-3 [1].
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Ac-AAVALLPAVLLALLAP-LEHD-CHO
T80537623948-42-5
Ac-AAVALLPAVLLALLAP-LEHD-CHO is a caspase inhibitor targeting caspases 4, 5, and 9, demonstrating protective effects in MCF-7 cells treated with Neocarzinostatin [1].
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Ac-IETD-CHO TFA
T78586L
Ac-IETD-CHO TFA is a granzyme B and caspase-8 inhibitor that inhibits caspase8 activity by blocking caspase3 precursor cleavage.Ac-IETD-CHO TFA inhibits Fas-mediated apoptosis.
    Inquiry
    Ac-DEVD-CHO
    TQ0146169332-60-9
    Ac-DEVD-CHO is a specific Caspase-3 inhibitor (Ki: 230 pM) with inhibitory effects on SLNT-induced apoptosis.
    • $68
    In Stock
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    Z-LEHD-fmk
    T21835210345-04-3
    Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis. Z-LEHD-FMK exhibits antitumor and neuroprotective activity, increases the yield of in vitro-produced preimplantation embryos of [Bubalus bubalis], and alters the cellular stress response.
    • $198
    In Stock
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    Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone
    T823881926163-65-6
    Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable, non-toxic inhibitor that irreversibly binds to activated caspase-3 in apoptotic cells, with fluorescence intensity measurable via flow cytometry, microwell plate reader, or fluorescence microscopy [1].
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    Z-WEHD-FMK
    TP2161210345-00-9
    Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1 5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).
    • $373
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    Z-Ala-Ala-Asp-CMK
    T80745183284-21-1
    Z-Ala-Ala-Asp-chloromethylketone (Z-AAD-CMK) is a selective inhibitor of granzyme B [1].
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    Tripeptide-32
    T802011185583-20-3
    Tripeptide-32 is a bioactive peptide recognized for its anti-aging properties, commonly utilized as an ingredient in cosmetics [1].
    • $50
    7-10 days
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    Caspase-8-IN-1
    T76571886462-83-5
    Caspase-8-IN-1 is a potent caspase-8 inhibitor [1] .
    • Inquiry Price
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    Arg-Gly-Asp-Ser acetate
    T10366L
    Arg-Gly-Asp-Ser acetate is an integrin binding sequence that directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1. Arg-Gly-Asp-Ser acetate inhibits integrin receptor function.
    • $29
    In Stock
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    TargetMol | Inhibitor Sale
    Z-VEID-FMK
    T23555
    When compared to other caspase inhibitors, Z-DRHD-FMK inhibited caspase 6 activity more effectively than the general caspase inhibitor of Z-Val-Ala-Asp (OMe)-fluoromethy ketone (Z-VAD-FMK) or the caspase 6 inhibitor Z-Val-Glu(Ome)-Ile-Asp(OMe)-fluorometh
    • $106
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    TargetMol | Citations Cited
    Ac-DEVD-AFC
    TP1326201608-14-2
    Ac-DEVD-AFC, a fluorogenic substrate, undergoes cleavage by caspase-3, producing a blue fluorescent compound upon excitation at 400 nm, which can be quantified at an emission maximum of 505 nm.
    • $47
    In Stock
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    H-Gly-Arg-Gly-Asp-Asn-Pro-OH
    T7570114681-65-1
    H-Gly-Arg-Gly-Asp-Asn-Pro-OH (GRGDNP) is a integrin-ligand interactions inhibitor.
    • $31
    In Stock
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    TargetMol | Inhibitor Sale
    Ac-DEVD-pNA
    T7816189950-66-1
    Ac-DEVD-pNA is the preferred peptidic substrate for caspase-3.
    • $30
    In Stock
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    TargetMol | Inhibitor Sale
    Z-LE(OMe)TD(OMe)-FMK
    T72435210344-93-7
    Z-LE(OMe)TD(OMe)-FMK is a selective inhibitor of caspase-8, effectively preventing cellular apoptosis.
    • $1,820
    8-10 weeks
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    Z-LLE-AMC
    T37417348086-66-8
    Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.
    • $110
    35 days
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    YVAD-CHO
    T80513153604-27-4
    YVAD-CHO is an inhibitor of interleukin-1β converting enzyme (ICE, caspase 1) that has been shown to partially mitigate motoneuron death in mice with lesioned facial nerves [1].
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    Amyloid 17-42
    T76393155178-13-5
    Amyloid 17-42 (Aβ(17-42)), a significant component of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, results from alpha- and gamma-secretase cleavage of amyloid precursor protein (APP) and can trigger neuronal apoptosis via the Fas-like caspase-8 activation pathway [1].
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    AC-VEID-CHO TFA
    T73683
    AC-VEID-CHO (TFA) is a peptide-derived inhibitor targeting Caspases-6, -3, and -7, with IC50 values of 16.2 nM, 13.6 nM, and 162.1 nM, respectively. This compound demonstrates significant inhibitory potency and is applicable in the study of neurodegenerative diseases, such as Alzheimer’s and Huntington’s disease [1].
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    Parstatin(mouse)
    TP19661065756-01-5
    Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apo
    • $475
    Backorder
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    Ac-Trp-Glu-His-Asp-AMC
    T76606189275-74-9
    Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 [1].
    • Inquiry Price
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    Ac-VDVAD-AFC
    T36345210344-94-8
    Ac-VDVAD-AFC, a caspase-specific fluorescent substrate, detects caspase-3-like and caspase-2 activities, making it valuable for tumor and cancer-related research.
    • $1,203
    Backorder
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    AY 254
    T411892093408-03-6
    AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro.
    • $970
    Backorder
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    Ac-ESMD-CHO
    T80076191338-87-1
    Ac-ESMD-CHO functions as an inhibitor of both caspase-3 and caspase-7, specifically obstructing the proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site [1] [2].
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    Parstatin(human)
    TP19651065755-99-8
    Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apop
    • $364
    Backorder
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    Ac-WEHD-AFC TFA
    T76091
    Ac-WEHD-AFC TFA is a fluorogenic substrate for caspase-1, used to measure the enzyme's activity in tumor and inflammation research [1].
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    Ac-Trp-Glu-His-Asp-Aldehyde
    T76600189275-71-6
    Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor, with a K_i value of 56 pM [1][2].
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    Arg-Gly-Asp-Ser TFA
    T73870
    Arg-Gly-Asp-Ser (TFA) is an integrin-binding sequence that inhibits integrin receptor function by specifically and directly binding to pro-caspase-8, pro-caspase-9, and pro-caspase-3, without interacting with pro-caspase-1 [1].
    • Inquiry Price
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    RGD peptide (GRGDNP) (TFA)
    T76007
    RGD peptide (GRGDNP) TFA functions as an inhibitor of integrin-ligand interactions, competitively blocking α5β1's interaction with the extracellular matrix (ECM). It induces apoptosis by triggering conformational changes that facilitate pro-caspase-3 activation and autoprocessing. Furthermore, RGD peptide (GRGDNP) TFA is critical in regulating cell adhesion, migration, growth, and differentiation [1] [2] [3].
    • $79
    5 days
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    Z-LEED-FMK
    T766651135688-38-8
    Z-LEED-FMK is a chemical compound that acts as an inhibitor for caspase-13 and caspase-4. Additionally, it impedes caspase-1 processing in S. typhimurium-infected macrophages [1] [2].
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    Ac-LETD-AFC
    T36343210345-02-1
    Ac-LETD-AFC is a fluorescent substrate specifically cleaved by caspase-8 and can be used to quantify caspase activity by fluorescence detection of free AFC.Ac-LETD-AFC has an excitation wavelength of 400 nm and an emission wavelength of 505 nm.
    • $93
    In Stock
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    BDS-I
    T80173207621-38-3
    BDS-I, a marine toxin derived from Anemonia sulcata, functions as a selective inhibitor of the potassium channel, specifically targeting Kv3.4. It impedes the Aβ1-42-induced augmentation of Kv3.4 activity, caspase-3 activation, and distortion of nuclear morphology in NGF-differentiated PC-12 cells. Moreover, BDS-I effectively counteracts the cell death induced by the Aβ peptide [1].
    • Inquiry Price
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    GPR
    T7628847295-77-2
    GPR, a tripeptide, shows promise in Alzheimer's disease (AD) research by protecting cultured rat hippocampal neurons from amyloid-beta (Aβ)-induced death through the inhibition of caspase-3/p53-dependent apoptosis.
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    Ac-DEVD-CMK TFA
    T75706
    Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective, irreversible caspase-3 inhibitor, preventing apoptosis induced by elevated glucose levels or 3,20-dibenzoate (IDB) in various experimental contexts, as supported by references [1] [2] [3].
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    Edratide
    T76300433922-67-9
    Edratide (TV 4710), a 19-amino-acid synthetic peptide derived from the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that exhibits the 16/6 Id idiotype, has been found to lower apoptosis rates and regulate the expression of caspase-8 and caspase-3 downward, while increasing Bcl-xL expression. It shows promise for systemic lupus erythematosus (SLE) research [1] [2] [3].
    • Inquiry Price
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    Z-LEHD-FMK TFA
    T40602524746-03-0
    Z-LEHD-FMK TFA is a specific and irreversible inhibitor of caspase-9, providing protection against detrimental reperfusion injury and moderating apoptosis, with demonstrated neuroprotective potential in a rat model of spinal cord trauma.
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