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IDN-7314
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Catalog No. T219011 Copy Product Info
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IDN-7314 is a broad-spectrum caspase inhibitor with an IC50 ranging from 0.2 to 7 nM against all tested caspases. It effectively eliminates caspase-3/7 activity induced by Jo2. Additionally, IDN-7314 reduces procoagulant activity of tissue factor in hepatocytes. It is applicable in studies of chemically induced hepatitis, fulminant hepatic failure, and apoptotic liver damage.
IDN-7314
Cas No. 254750-11-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | IDN-7314 is a broad-spectrum caspase inhibitor with an IC50 ranging from 0.2 to 7 nM against all tested caspases. It effectively eliminates caspase-3/7 activity induced by Jo2. Additionally, IDN-7314 reduces procoagulant activity of tissue factor in hepatocytes. It is applicable in studies of chemically induced hepatitis, fulminant hepatic failure, and apoptotic liver damage. |
| In vitro | IDN-7314 is a potent pan-caspase inhibitor, exhibiting IC 50 values ranging from 0.2 to 7 nM across all tested caspases. At a concentration of 100 nM, IDN-7314 completely abolishes Jo2-induced caspase-3/7 activity and significantly reduces the procoagulant tissue factor activity of hepatocytes along with the release of tissue factor-positive microvesicles. |
| In vivo | IDN-7314 (10 mg/kg; intraperitoneal injection) effectively inhibits hepatocyte apoptosis and caspase-3 activation in female Sprague-Dawley rats induced by galactosamine, with a reduction in apoptotic hepatocytes by 76%-71%, depending on the dosing regimen. However, it only slightly reduces plasma ALT levels and necrotic cell death in this model. Additionally, IDN-7314 (intraperitoneal injection; single dose, 3 mg/kg) inhibits caspase activation, prevents procoagulant changes, and alleviates hepatocellular damage in mice with Fas-induced apoptotic liver injury. |
| Molecular Weight | 549.38 |
| Formula | C22H17F6N3O7 |
| Cas No. | 254750-11-3 |
| Smiles | O(CC([C@@H](NC([C@@H](NC(C(NC1=C(F)C=CC=C1F)=O)=O)C)=O)CC(O)=O)=O)C2=C(F)C(F)=CC(F)=C2F |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: IDN-7314 in vivo | IDN-7314 in vitro | IDN-7314 formula | IDN-7314 molecular weight
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