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GPR acetate
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Catalog No. T76288L
Alias GPR acetate（47295-77-2 Free base）
GPR acetate (47295-77-2 Free base) is a tripeptide containing three amino acids that inhibits caspase-3/p53-dependent apoptosis mechanisms, protecting cultured rat hippocampal neurons from Aβ-induced death. It is suitable for Alzheimer's disease (AD) research.
GPR acetate
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Purity: 99.40%
Catalog No. T76288LAlias GPR acetate（47295-77-2 Free base）
GPR acetate (47295-77-2 Free base) is a tripeptide containing three amino acids that inhibits caspase-3/p53-dependent apoptosis mechanisms, protecting cultured rat hippocampal neurons from Aβ-induced death. It is suitable for Alzheimer's disease (AD) research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $31 | - | In Stock | |
| 5 mg | $68 | - | In Stock | |
| 10 mg | $103 | - | In Stock | |
| 25 mg | $174 | - | In Stock | |
| 50 mg | $260 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.40%
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Product Introduction
Bioactivity
Chemical Properties
| Description | GPR acetate (47295-77-2 Free base) is a tripeptide containing three amino acids that inhibits caspase-3/p53-dependent apoptosis mechanisms, protecting cultured rat hippocampal neurons from Aβ-induced death. It is suitable for Alzheimer's disease (AD) research. |
| In vitro | GPR acetate (1-100 μM; 24/48 hours) inhibits Aβ-mediated increases in lactate dehydrogenase (LDH) release[1]. GPR acetate (50 μM; 24/48 hours) inhibited Aβ-mediated inhibition of neuronal MTT reduction and caspase-3 activation [1]. GPR acetate (50 μM; 3 days) suppressed Aβ-induced increase in p53-positive cells [1]. |
| Synonyms | GPR acetate（47295-77-2 Free base） |
| Molecular Weight | 328.37 (free base) |
| Formula | C13H24N6O4.xC2H4O2 |
| Smiles | N=C(N)NCCC[C@@H](C(O)=O)NC([C@H]1N(CCC1)C(CN)=O)=O.CC(O)=O |
| Color | White |
| Appearance | Solid |
| Sequence | H-Gly-Pro-Arg-OH |
| Sequence Short | H-GPR-OH |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 100 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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