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Alkaloids

Alkaloids are a class of naturally occurring organic compounds that mostly contain basic nitrogen atoms, produced by a large variety of organisms including bacteria, fungi, plants, and animals. Alkaloids have a wide range of pharmacological activities including antimalarial (e.g. quinine), antiasthma (e.g. ephedrine), anticancer (e.g. homoharringtonine), cholinomimetic (e.g. galantamine), vasodilatory (e.g. vincamine), antiarrhythmic (e.g. quinidine), analgesic (e.g. morphine), antibacterial (e.g. chelerythrine), and antihyperglycemic activities (e.g. piperine). Many have found use in traditional or modern medicine, or as starting points for drug discovery. Other alkaloids possess psychotropic (e.g. psilocin) and stimulant activities (e.g. cocaine, caffeine, nicotine, theobromine), and have been used in entheogenic rituals or as recreational drugs. Alkaloids can be toxic too (e.g. atropine, tubocurarine).

  • Syrosingopine
    TN225284-36-6
    Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.
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  • (+)-Sparteine
    T7853492-08-0
    (+)-Sparteine (Pachycarpine) is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent
    • $42
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  • Vinorelbine ditartrate
    T6213125317-39-7
    Vinorelbine ditartrate (KW-2307), a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
    • $30
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  • Cephalomannine
    T221771610-00-9
    Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.
    • $60
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  • Stachydrine Hydrochloride
    T32514136-37-2
    Stachydrine Hydrochloride is an effective component that mainly extracted from the leaf of Leonurussibiricus.
    • $46
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  • Rhodamine B
    T797581-88-9
    Rhodamine B (Brilliant Pink B) is used as a tracer dye in water to determine the rate and direction of flow and transport.
    • $33
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  • Pilocarpine Hydrochloride
    T080454-71-7
    Pilocarpine Hydrochloride (NSC 5746 HCl) , a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy.
    • $54
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  • Chelidonine
    T5S0055476-32-4
    1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. 3. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1/2.
    • $96
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  • Sophoridine
    T33396882-68-4
    Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure-activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer activity. Among the compounds, 6b bearing bromoacetyl side-chain afforded a potential effect against four human tumor cell lines (liver, colon, breast, and lung). The mechanism of action of 6b is to inhibit the activity of DNA topoisomerase I, followed by the S-phase arrest and then cause apoptotic cell death, similar to that of its parent 1.
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  • Cepharanthine
    T0131481-49-2
    Cepharanthine (NSC-623442), a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and inhibits cytokine production.
    • $45
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  • Tropine
    T5595120-29-6
    Tropine is a secondary metabolite of the Solanaceae family of plants and is an anticholinergic reagent. It is a common intermediate used in the synthesis of various biologically active alkaloids (e.g. hyoscyamine, scopolamine).
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  • Dopamine hydrochloride
    T164462-31-7
    Dopamine hydrochloride (ASL279) is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine hydrochloride binds to alpha-1- and beta-1- adrenergic receptors.
    • $30
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  • L-(R,S)-Tetrahydropalmatine
    T271410097-84-4
    L-(R,S)-Tetrahydropalmatine (Rotundine) is extracted from Corydalis yanhusuo W. T. Wang.
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  • Rauwolscine hydrochloride
    T44296211-32-1
    Rauwolscine hydrochloride (Isoyohimbine hydrochloride) , a natural alkaloid, is a specific and reversible α2-adrenergic receptor antagonist (Ki: 12 nM) [1]. It is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors [1]. Rauwolscine hydrochloride also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki: 14.3 nM) and as a weak partial agonist at 5-HT1A (IC50: 1.3 μM) [3]. The α2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior [5].
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  • Crassicauline A
    T3S189279592-91-9
    1. Crassicauline A (Crassicauline I) and Yunaconitine possesses feeding deterrent activity against T. castaneum adults, with EC(5) values of 1134.5 and 653.4 ppm, respectively.
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  • Sophocarpine monohydrate
    T2746145572-44-7
    Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
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  • (S)-N-Glycidylphthalimide
    TN6603161596-47-0
    (S)-N-Glycidylphthalimide (2-[(2S)-2-Oxiranylmethyl]-1H-isoindole-1,3(2H)-dione) is a phthalimide derivative used as an intermediate in the preparation of the antibiotic Linezolid.
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  • Methyl indole-3-carboxylate
    T5868942-24-5
    Methyl indole-3-carboxylate (Methyl 3-indolecarboxylate) is a natural product isolated from Heracleum candicans.
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  • Thiamine monochloride
    T2O274159-43-8
    Thiamine monochloride (Vitamin B1) is an essential vitamin with erythropoietic, glucose-regulatory, antioxidant, and mood-regulatory properties.Thiamine monochloride inhibits lead-induced lipid peroxidation, thereby preventing lead poisoning.Thiamine monochloride plays an important role in the production of energy by the cells that ingest the food, and enhances normal Thiamine monochloride plays an important role in the energy production of ingested food cells and enhances normal neuronal activity.
    • $41
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  • Thymidine
    TWP291150-89-5
    1. Thymidine (DThyd) overload due to Thymidine phosphorylase deficiency, and mitochondrial toxicity caused by antiviral Thymidine analogues.
    • $45
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  • Uracil
    T006966-22-8
    Uracil is a common naturally occurring pyrimidine found in RNA, it base pairs with adenine and is replaced by thymine in DNA. Methylation of uracil produces thymine. Uracil's use in the body is to help carry out the synthesis of many enzymes necessary for cell function through bonding with riboses and phosphates. Uracil serves as allosteric regulator and coenzyme for many important biochemical reactions.
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  • L-Hyoscyamine sulfate
    T4S1619620-61-1
    L-Hyoscyamine sulfate (Levsin Sulfate) is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility.
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  • Methyl anthranilate
    TN1925134-20-3
    Methyl anthranilate is a natural product. Methyl anthranilate is a novel quorum sensing inhibitor and anti-biofilm agent against Aeromonas sobria
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  • Alpha-Solamarine
    TN221620318-30-3
    Alpha-Solamarine (Solamarine) is a glycoside alkaloid isolated from Solanum nigrum.Alpha-Solamarine is inhibitory to Globodera pallid and may be used for plant defense.
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  • Berberine
    T4S07972086-83-1
    1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3. Berberine seems to act as an herbal antidepressant and a neuroprotector against neurodegenerative disorders. 4. Berberine is used in histology for staining heparin in mast cells. As a natural dye, berberine has a colour index of 7516. 5. Berberine reduces hepatic fat content in rats with nonalcoholic fatty liver disease; also prevents proliferation of hepatic stellate cells (HSCs), which are central for the development of fibrosis during liver injury. 6. Berberine can ameliorate proinflammatory cytokines-induced intestinal epithelial tight junction damage in vitro, and berberine may be one of the targeted therapeutic agents that can restore barrier function in intestinal disease states. 7. Berberine has antineoplastic effects, including breast cancer, leukemia, melanoma, epidermoid carcinoma, hepatoma, pancreatic cancer, oral carcinoma, tongue carcinoma, glioblastoma, prostate carcinoma and gastric carcinoma, etc.
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  • Anisodamine Hydrobromide
    T830455449-49-5
    Anisodamine Hydrobromide (6-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.
    • $66
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  • Vincristine sulfate
    T12702068-78-2
    Vincristine sulfate (Leurocristine sulfate) binds irreversibly to microtubules and spindle proteins in S phase and interferes the formation of the mitotic spindle.
    • $64
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  • Vinorelbine
    T019071486-22-1
    Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase.
    • $90
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  • Pilocarpine nitrate
    T1231148-72-1
    Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
    • $41
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  • Aloperine
    T637756293-29-9
    Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
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  • Betaine chloride
    T0019590-46-5
    Betaine chloride (Betaine hydrochloride) is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DNA by decreasing the formation of secondary structure in GC-rich regions.
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  • Benzylamine hydrochloride
    TN34973287-99-8
    Benzylamine hydrochloride, made of benzylamine and hydrochloric acid, is used to treat motion sickness and ascariasis, with antiemesis properties.
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  • Sanguinarine chloride
    T01295578-73-4
    Sanguinarine chloride (Pseudochelerythrine chloride), a benzophenanthridine alkaloid, stimulates apoptosis by activating the production of reactive oxygen species (ROS).
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  • Guanine
    T2A253773-40-5
    Guanine (2-Aminohypoxanthine) is a purine base that is a constituent of nucleotides occurring in nucleic acids.
    • $42
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  • Berberine hydrogen sulphate
    T5S0814633-66-9
    Berberine hydrogen sulphate (Umbellatine Sulfate) , an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.
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  • Camptothecin
    T11237689-03-4
    Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
    • $46
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  • Hordenine
    T2890539-15-1
    Hordenine, an effective phenylethylamine alkaloid, has antibacterial activities.
    • $50
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  • Indole-3-carbinol
    T2947700-06-1
    Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
    • $29
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  • Evodiamine
    T2868518-17-2
    Evodiamine (d-Evodiamine) is an alkaloid isolated from the fruit of daylily and has a variety of biological activities including anti-inflammatory, anti-obesity and anti-tumor.
    • $42
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  • Arecoline hydrobromide
    T2198300-08-3
    Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist.
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  • L-(+)-Abrine
    T5718526-31-8
    L-(+)-Abrine (L-N-Methyltryptophan) is a toxic protein found in the jequirity seed.,can be used as a biomarker for abrin exposure.
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  • Berberine chloride
    T0461633-65-8
    Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae and also found in many other plants. It is relatively toxic to parenterally but has been used orally for various fungal and parasitic infections and an anti-diarrheal.
    • $29
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  • Liensinine diperchlorate
    T4S11025088-90-4
    Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome-lysosome fusion and exhibits biological activities such as anti-arrhythmic, anti-hypertensive, anti-pulmonary fibrosis, and vascular smooth muscle relaxation.
    • $41
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  • Candicine
    TN70646656-13-9
    Candicine (N, N, N-trimethyltyramine chloride) is a natural product from Stapelia gigantea.
    • $148
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  • Catharanthine sulfate
    T302370674-90-7
    Catharanthine inhibits nicotinic receptor-mediated diaphragm contractions.
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  • Trachelanthine
    TC0014510-19-0
    Trachelanthine is a natural product from Eupatorium fortunei.
    • $134
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  • (R)-(+)-Corypalmine
    T4S079413063-54-2
    1. (R)-(+)-Corypalmine ((+)-Corypalmine) shows strong papaverine-like activity.
    • $162
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  • DL-Laudanosine
    T81751699-51-0
    DL-Laudanosine (Laudanosine) is a recognized metabolite of atracurium and cisatracurium.
    • $42
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  • yibeinoside A
    T2S011298985-24-1
    Yibeinoside A (Sinpeinine-3-O-β-glucoside) is an alkaloid from Fritillaria pallidiflora.
    • $78
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  • L-Sophoridine
    T303083148-91-8
    L-Sophoridine (Matridin-15-one) , a natural product obtained from medicinal plants, which has a variety of pharmacological effects, including anti-Y effects, and selectively induces apoptotic cell death in a variety of human Y cells in vitro and in vivo; however, its mechanism of action needs to be further elaborated.
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