caspase

Z-VAD(OMe)-FMK is a pan-caspase inhibitor with irreversible properties; Z-VAD(OMe)-FMK is also an inhibitor of ubiquitin C terminal hydrolase L1 (UCHL1), which is irreversibly modified by targeting the UCHL1 active site.

Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases.Z-VAD-FMK binds to activated caspases and inhibits apoptosis.Z-VAD-FMK does not inhibit UCHL1 activity, even at concentrations up to 440 μM.

Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) is a broad range caspase inhibitor. Boc-Asp(OME)-Fluoromethyl Ketone inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.

(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor of ubiquitin C-terminal hydrolase L1 (UCHL1), irreversibly modified by targeting the UCHL1 active site.

Biotin-VAD-FMK is a cell-permeable, irreversible biotin-labeled inhibitor of caspase. It is used to identify active caspases in cell lysates.

Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 µM).

Z-DEVD-FMK (Caspase-3 Inhibitor) is a Caspase-3 inhibitor (IC50=18 μM), featuring selectivity, irreversibility and cell permeability. Z-DEVD-FMK can inhibit caspase activation induced apoptosis.

Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.

Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a cell-permeable, selective inhibitor of caspase 8.

AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.

Caspase-8-IN-1 is a potent caspase-8 inhibitor [1] .

Ac-YVAD-CHO (L 709049) is a selective and potent tetrapeptide interleukin 1β-converting enzyme (ICE) and caspase-1 (ICE)-like protease inhibitor with anti-inflammatory activity, inhibits cancer cell growth, and inhibits the production of mature IL-lβ. Ac-YVAD-CHO attenuates quinolinic acid-induced p53 increase and apoptosis in rat striatum.

Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis. Z-LEHD-FMK exhibits antitumor and neuroprotective activity, increases the yield of in vitro-produced preimplantation embryos of [Bubalus bubalis], and alters the cellular stress response.

Z-VEID-FMK is a selective and cell-permeable caspase-6 peptide inhibitor that irreversibly covalently binds to the active site of the enzyme, thereby inhibiting apoptosis and DNA breakage.

Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.

Z-VDVA-(DL-Asp)-FMK, a derivative of Z-VDVAD-FMK, is specifically designed as a caspase-2 inhibitor.

Z-LEHD-FMK TFA is a specific and irreversible inhibitor of caspase-9, providing protection against detrimental reperfusion injury and moderating apoptosis, with demonstrated neuroprotective potential in a rat model of spinal cord trauma.

Z-LE(OMe)TD(OMe)-FMK is a selective inhibitor of caspase-8, effectively preventing cellular apoptosis.

Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor with potential anticancer activity, capable of eliminating LPS-induced GCLC protein degradation and inducing apoptosis in cancer cells.

AC-VEID-CHO (TFA) is a peptide-derived inhibitor targeting Caspases-6, -3, and -7, with IC50 values of 16.2 nM, 13.6 nM, and 162.1 nM, respectively. This compound demonstrates significant inhibitory potency and is applicable in the study of neurodegenerative diseases, such as Alzheimer's and Huntington's disease [1].

H-Gly-Arg-Gly-Asp-Asn-Pro-OH (GRGDNP) is a integrin-ligand interactions inhibitor.

Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective, irreversible caspase-3 inhibitor, preventing apoptosis induced by elevated glucose levels or 3,20-dibenzoate (IDB) in various experimental contexts, as supported by references [1] [2] [3].

Ac-WEHD-AFC TFA is a fluorogenic substrate for caspase-1, used to measure the enzyme's activity in tumor and inflammation research [1].

GPR, a tripeptide, shows promise in Alzheimer's disease (AD) research by protecting cultured rat hippocampal neurons from amyloid-beta (Aβ)-induced death through the inhibition of caspase-3/p53-dependent apoptosis.