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Results for "caspase" in TargetMol Product Catalog
  • Inhibitor Products
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Z-VAD-FMK
T7020161401-82-7
Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases.Z-VAD-FMK binds to activated caspases and inhibits apoptosis.Z-VAD-FMK does not inhibit UCHL1 activity, even at concentrations up to 440 μM.
  • $121
In Stock
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TargetMol | Citations Cited
Caspase-3 activator 1
T79743
Caspase-3 activator 1 (compound 4b), a Ru(III) metal complex, effectively inhibits gastric tumor growth and metastasis by mediating caspase-3 cleavage. This cleavage enables Caspase-3 to process gasdermin E (GSDME), which results in the production of the GSDME-N terminus, leading to perforation of the gastric tumor cell membrane. Furthermore, compound 4b induces pyroptosis and subsequent immune responses. It can be incorporated with decitabine (DCT) into the 4b-DCT-Lip lipid delivery system [1].
  • $195
8-10 weeks
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QTY
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Caspase-8-IN-1
T76571886462-83-5
Caspase-8-IN-1 is a potent caspase-8 inhibitor [1] .
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Caspase-3 activator 3
T82774
Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic activity with IC50 values of 42.89 μM and 33.61 μM, respectively [1].
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Caspase-3 activator 2
T82775
Caspase-3 Activator 2 (Compound 2f) is a caspase 3 activator with cytotoxic effects on HL-60 and K562 cells, exhibiting IC 50 values of 33.52 μM and 76.90 μM, respectively [1]. It facilitates apoptosis, rendering it useful in cancer research.
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Ac-DEVD-CHO acetate
TQ0146L
Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.
  • $70
In Stock
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TargetMol | Citations Cited
Z-DEVD-FMK Caspase-3 Inhibitor
T83963634911-78-7
Z-DEVD-FMK, a Caspase-3 Inhibitor, is an irreversible, cell-permeable inhibitor of caspase-3/CPP32 that impedes tumor cell apoptosis. In vivo studies show it offers neuroprotection in rat hippocampi post-seizures and considerably diminishes post-traumatic apoptosis, enhancing neurological recovery in rats before and after traumatic brain injury induction.
  • $1,060
35 days
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Caspase-9 Inhibitor III
T72281403848-57-7
Caspase-9 Inhibitor III (Ac-LEHD-cmk), a caspase-9 inhibitor, exhibits protective effects against ischemia-reperfusion-induced myocardial injury.
  • $1,180
6-8 weeks
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QTY
Caspase-6-IN-1
T706501438463-77-4
Caspase-6-IN-1 is a novel Allosteric Inhibitor of Caspase-6 Activation, blocking the interaction between C6 and mHTT1-586.
  • $1,520
6-8 weeks
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QTY
Caspase-3-IN-1
T63479872254-32-5
Caspase-3-IN-1 is a potent inhibitor of Caspase-3 (IC50: 14.5 nM).
  • $650
6-8 weeks
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Caspase-3/7 activator 3
T72316
Caspase-3/7 Activator 3 is a potent and tumor-selective compound that effectively activates Caspase-3/7, demonstrating significant anti-proliferative activity and a high capacity to induce apoptosis.
  • $1,520
6-8 weeks
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Caspase-3/7 activator 2
T72315
Caspase-3/7 Activator 2 is a potent compound that selectively activates Caspase-3/7, demonstrating tumor specificity, anti-proliferative properties, and a high capacity for inducing apoptosis.
  • $1,520
6-8 weeks
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Z-DEVD-FMK
T6005210344-95-9
Z-DEVD-FMK (Caspase-3 Inhibitor) is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10.
  • $52
In Stock
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TargetMol | Citations Cited
Ac-YVAD-CMK
T36347178603-78-6
Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
  • $64
In Stock
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MMPSI
T21871220509-74-0
MMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a concentration-dependent manner.MMPSI can be used to study cardioprotection and myocardial injury.
  • $98
In Stock
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Ivachtin
T11696745046-84-8
Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases.
  • $135
In Stock
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Z-IETD-FMK
T7019210344-98-2
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective caspase 8 inhibitor, which has cell permeable.
  • $127
In Stock
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TargetMol | Citations Cited
PROCYANIDIN C1
TN210337064-30-5
Procyanidin C1 is a natural product, with anti-inflammatory effects, and induces apoptosis.
  • $72
In Stock
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TargetMol | Citations Cited
Anisperimus
T30077170368-04-4In house
Anisperimus (LF 15-0195) is an immunosuppressant that enhances activation-induced T-cell death by promoting caspase-8 and caspase-10 activation at the DISC level, and prevents CNS autoimmunity by promoting the development of Foxp3-expressing regulatory CD4 T cells.
  • $633
In Stock
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Iptacopan
T118641644670-37-0
Iptacopan (LNP023) is an inhibitor with high affinity for factor B.
  • $132
In Stock
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Z-VAD(OMe)-FMK
T6013187389-52-2
Z-VAD(OMe)-FMK is a pan-caspase inhibitor with irreversible properties; Z-VAD(OMe)-FMK is also an inhibitor of ubiquitin C terminal hydrolase L1 (UCHL1), which is irreversibly modified by targeting the UCHL1 active site.
  • $52
In Stock
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TargetMol | Citations Cited
Chelidonine
T5S0055476-32-4
1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. 3. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1/2.
  • $96
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TargetMol | Citations Cited
Diclofenac Potassium
T647015307-81-0
Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
  • $39
In Stock
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CSRM617 hydrochloride
T10896L1353749-74-2In house
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 ( OC2, a master regulator of androgen receptor) with a K d of 7.43 uM in SPR assays, directly binds to OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the mouse model of prostate cancer [1]
  • $56
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2-methoxycinnamaldehyde
T74521504-74-1
2-methoxycinnamaldehyde is a natural compound of Cinnamomum cassia,has been widely studied with regard to its antitumor activity.
  • $41
In Stock
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Belnacasan
T6090273404-37-8
Belnacasan (VX-765) is an orally active IL-converting enzyme/caspase-1 inhibitor.
  • $31
In Stock
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TargetMol | Citations Cited
Orientin
T6S072128608-75-5
1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier integrity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases. 3. Orientin has neuroprotection effect by the intracellular mediation of caspase activity; may alleviate cognitive deficits and oxidative stress in AD mice; can exert antidepressant-like effects on CUMS mice, specifically by improving central oxidative stress, neurotransmission, and neuroplasticity.
  • $29
In Stock
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TargetMol | Citations Cited
Glaucocalyxin A
T4S049879498-31-0
1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. 3. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. 4. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway. 5. Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand.
  • $100
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TargetMol | Citations Cited
2-Methoxyestradiol
T2220362-07-2
2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis.
  • $50
In Stock
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TargetMol | Citations Cited
Bufotalin
T5A2461471-95-4
1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.
  • $88
In Stock
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magnolin
T385731008-18-1
Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.
  • $93
In Stock
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Ginkgetin
T4S2126481-46-9
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead
  • $120
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TargetMol | Citations Cited
Crustecdysone
T28815289-74-7
Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.
  • $60
In Stock
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TCH-165
T170111446350-60-2
TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs.
  • $116
In Stock
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VU0285655-1
T263261158347-73-9
VU0285655-1(BML-280) is a potent and selective phospholipase D2 (PLD2) inhibitor that inhibits the proliferation of PLD2-deficient cells.VU0285655-1 has an inhibitory effect on high glucose-induced caspase-3 cleavage and reduction of cell viability.VU0285655-1 is used in the study of diabetic retinopathy.
  • $78
In Stock
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SKLB-163
T261931255099-06-9In house
SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
  • $137
In Stock
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Ac-YVAD-AOM
T78631154674-81-4
Ac-YVAD-AOM is a selective and potent caspase-1 inhibitor showing antitumor activity and potential analgesic activity.
  • $105
In Stock
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Arg-Gly-Asp-Ser acetate
T10366L
Arg-Gly-Asp-Ser acetate is an integrin binding sequence that directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1. Arg-Gly-Asp-Ser acetate inhibits integrin receptor function.
  • $35
In Stock
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(-)-Anonaine
TN13931862-41-5In house
(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces apoptosis in human cervical cancer (HeLa) cells, induces DNA damage and inhibits the growth and migration of human lung cancer h1299 cells through Bax and caspase-dependent pathways.
  • $340
In Stock
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SF5
T2478434634-22-5
SF5 is an inhibitor of the apoptosis pathway. Which is through the JNK-p53-caspase apoptotic cascade.
  • $40
In Stock
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EF24
T27242342808-40-6In house
EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral squamous cell carcinoma (OSCC) via deactivation of the MAPK/ERK signaling pathway.
  • $33
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PAF (C16)
T2154774389-68-7In house
PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled receptor (PAFR). PAF (C16) has shown anti-apoptotic and anti-inflammatory activity in vitro, inhibiting Caspase-dependent apoptosis by interacting with its receptor (PAF-R) to perform cell signaling.
  • Inquiry Price
6-8 weeks
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OUP-186
T282751480830-24-7In house
OUP-186 is a high affinity and human/rat species-selective antagonist of histamine H3 receptor. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 μM. OUP-186 potently induced cell dea
  • $1,520
6-8 weeks
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TargetMol | Inhibitor Sale
EP1013
T11210223568-55-6In house
EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.
  • $759
8-10 weeks
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GS-6201
T15418752222-83-6In house
GS-6201 (CVT-6883) is a selective antagonist of adenosine A2B receptor. GS-6201 shows high affinity and selectivity for the human adenosine A2B receptors with a Ki of 22 nM.
  • $37
In Stock
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Cysteine protease inhibitor-2
T10924612048-23-4In house
Cysteine protease inhibitor 2 is a cysteine protease inhibitor. Cysteine protease inhibitor 2 inhibited DCT116 and PC3 cells with GI50 values of 6.5 μM and 4.4 μM, respectively.
  • $1,520
6-8 weeks
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Ubiquitin Isopeptidase Inhibitor I, G5
T17192108477-18-5In house
Ubiquitin Isopeptidase Inhibitor I, G5 is a caspase-independent inducer of cell necrosis that induces cell death via the death receptor pathway (IC50 of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively).
  • $74
5 days
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Tauroursodeoxycholate sodium
T699335807-85-3
Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
  • $30
In Stock
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TargetMol | Citations Cited
Q-VD-OPH
T02821135695-98-5
Q-VD-OPH (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a pan-caspase inhibitor with potent antiapoptotic properties.
  • $47
In Stock
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TargetMol | Citations Cited
Z-VEID-FMK
T23555
When compared to other caspase inhibitors, Z-DRHD-FMK inhibited caspase 6 activity more effectively than the general caspase inhibitor of Z-Val-Ala-Asp (OMe)-fluoromethy ketone (Z-VAD-FMK) or the caspase 6 inhibitor Z-Val-Glu(Ome)-Ile-Asp(OMe)-fluorometh
  • $106
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