2720
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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12551 | PROTAC BRD4 ligand-1 | Epigenetic Reader Domain , Ligands for Target Protein for PROTAC | |
PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET. | |||
T5835 | PROTAC ERRα ligand 2 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor | |
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM) | |||
T15191 | PROTAC ERRα ligand 1 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor | |
PROTAC ERRα ligand 1 is an α (ERRα) antagonist of estrogen-related receptor (IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively). | |||
T13847 | PROTAC SGK3 degrader-1 | SGK3-PROTAC1 | SGK |
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, which induces degradation of endogenous SGK3.PROTAC SGK3 degrader-1 inhibits GDC0941-induced proliferation of can... | |||
T5437 | Gefitinib-based PROTAC 3 | EGFR | |
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectivel... | |||
T13722 | Homo-PROTAC pVHL30 degrader 1 | Others , Ligand for E3 Ligase | |
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC. | |||
T13848 | SMARCA-BD ligand 1 for Protac | Epigenetic Reader Domain | |
SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2 | |||
T13721 | Homo-PROTAC cereblon degrader 1 | Others , Ligand for E3 Ligase | |
Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3. | |||
T13890 | SMARCA-BD ligand 1 for Protac dihydrochloride | Epigenetic Reader Domain | |
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC. | |||
T74186 | PROTAC-O4I2 | Apoptosis , PROTACs | |
PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM. PROTAC-O4I2 induced apoptosis in K562 WT cells. | |||
T34168 | PROTAC-I | PROTAC I | |
PROTAC-I targets steroid hormone receptors for ubiquitination and degradation. | |||
T8745 | PROTAC BRAF-V600E degrader-1 | Compound 23 | Raf |
PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF. | |||
T39901 | PROTAC IRAK4 degrader-4 | PROTAC IRAK4 degrader-4 | |
PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4). | |||
T40073 | PROTAC BRD4 Degrader-10 | PROTAC BRD4 Degrader-10 | |
PROTAC BRD4 Degrader-10, also known as compound 8b, is a dual ligand-based PROTAC that combines ligands for von Hippel-Lindau and BRD4. To degrade the BRD4 protein in PC3 prostate cancer cells, PROTAC BRD4 Degrader-10 ca... | |||
T37329 | PROTAC IDO1 Degrader-1 | PROTAC IDO1 Degrader-1 | |
PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM)... | |||
T40334 | PROTAC IRAK3 degrade-1 | PROTAC IRAK3 degrade-1 | |
PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 ( IC 50 = 5 nM). | |||
T39997 | PROTAC CDK9 ligand-1 | PROTAC CDK9 ligand-1 | |
PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs. | |||
T40075 | PROTAC BRD4 Degrader-13 | PROTAC BRD4 Degrader-13 | |
PROTAC BRD4 Degrader-13 (compound 9d) is a bioactive compound that functions as a proteolysis targeting chimera (PROTAC), linking ligands for von Hippel-Lindau and BRD4 proteins. In the context of PC3 prostate cancer cel... | |||
T39996 | PROTAC CDK9 degrader-4 | PROTAC CDK9 degrader-4 | |
PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9... | |||
T36242 | PROTAC BRD4 Degrader-5 | PROTAC BRD4 Degrader-5 | |
PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1]. | |||
T39920 | PROTAC IRAK4 degrader-3 | PROTAC IRAK4 degrader-3 | |
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau. | |||
T39902 | PROTAC IRAK4 degrader-5 | PROTAC IRAK4 degrader-5 | |
PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader. | |||
T40074 | PROTAC BRD4 Degrader-15 | PROTAC BRD4 Degrader-15 | |
PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BR... | |||
T39903 | PROTAC IRAK4 degrader-6 | PROTAC IRAK4 degrader-6 | |
PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4). | |||
T18629 | PEG3-O-CH2COOH | PROTAC Linker 8 | Others , PROTAC Linker |
PEG3-O-CH2COOH (PROTAC Linker 8) (PROTAC Linker 8) is a PEG-based PROTAC linker. PEG3-O-CH2COOH can be used in the synthesis of SNIPERs. | |||
T39628 | PROTAC BRD4 ligand-2 | PROTAC BRD4 ligand-2 | |
PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718. | |||
T40072 | PROTAC BRD4 Degrader-9 | PROTAC BRD4 Degrader-9 | |
PROTAC BRD4 Degrader-9 (compound 8a) is a novel chemical compound consisting of ligands for von Hippel-Lindau and BRD4, connected by a PROTAC moiety. This compound can effectively degrade the BRD4 protein in PC3 prostate... | |||
T36628 | PROTAC BRD4 Degrader-8 | PROTAC BRD4 Degrader-8 | |
PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells... | |||
T18617 | NH2-C5-NH-Boc | PROTAC Linker 23 | Others , PROTAC Linker |
NH2-C5-NH-Boc (PROTAC Linker 23) (PROTAC Linker 23) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | |||
T18639 | Cl-C6-PEG4-O-CH2COOH | PROTAC Linker 4 | Others |
Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is an effective pegylated PROTAC linker, which is often used in PROTAC synthesis of chloroanes (HaloPROTACs). | |||
T7701 | Boc-NH-PEG3 | PROTAC Linker 10 | Others , PROTAC Linker |
Boc-NH-PEG3 (PROTAC Linker 10) is a PEG derivative containing a hydroxyl group and Boc-protected amino group, and is a PROTAC linker. | |||
T18616 | NH2-C2-NH-Boc | PROTAC Linker 22 | Others , PROTAC Linker |
NH2-C2-NH-Boc (PROTAC Linker 22) (PROTAC Linker 22) is a alkyl chain-based PROTAC linker. NH2-C2-NH-Boc can be used in the synthesis of PROTACs. | |||
T40143 | PROTAC CBP/P300 Degrader-1 | PROTAC CBP/P300 Degrader-1 | |
PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines. | |||
T32043 | HaloPROTAC3 | Halo PROTAC-3,HaloPROTAC 3,HaloPROTAC-3 | Ligand for E3 Ligase |
HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins. | |||
T40112 | PROTAC PD-1/PD-L1 degrader-1 | PROTAC PD-1/PD-L1 degrader-1 | |
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppr... | |||
T39837 | PROTAC ERRα Degrader-3 | ||
PROTAC ERRα Degrader-3 is a highly effective and selective von Hippel-Lindau-based ligand that efficiently degrades the ERRα protein. At a concentration of 30 nM, this compound exhibits a remarkable degradation capabilit... | |||
T39374 | PROTAC BET Degrader-10 | ||
PROTAC BET Degrader-10 (WO2017007612A1, example 37) is a highly efficient and selective small molecule compound designed to degrade BET protein BRD4. PROTAC BET Degrader-10 functions by utilizing specific ligands that co... | |||
T18595 | Dasatinib carbaldehyde | PROTAC ABL binding moiety 4,BMS-354825 carbaldehyde | Others , Ligands for Target Protein for PROTAC |
Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) is based on Dasatinib which is an ABL inhibitor, binds to the IAP ligand via a linker, and forms SNIPER [1]. | |||
T36243 | PROTAC RIPK degrader-6 | ||
PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder[1]. PROTACs is useful for the targeted degradation of proteins... | |||
T36256 | LC-2 | LC 2,PROTAC KRASG12C Degrader-LC-2,LC2 | PROTACs |
LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recru... | |||
T13845 | PROTAC PARP1 degrader | Others | |
PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μM). | |||
T36247 | TBK1 control PROTAC® 4 | ||
Negative control for TBK1 PROTAC 3i. Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T41267 | PROTAC(H-PGDS)-7 | ||
PROTAC(H-PGDS)-7 is a selective and potent small molecule hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degradation agent that exhibits degradation activity in KU812 cells with a DC50 of 17.3 pM. PROTAC(H-PGDS)-... | |||
T17995 | Halo PROTAC 1 | Others | |
Halo PROTAC 1 is a PROTAC, which is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce autophagy of an intracellular molecule are linked via a PEG l... | |||
T13915L | PROTAC BRD9-binding moiety 1 hydrochloride | PROTAC BRD9-binding moiety 1 hydrochloride (2097512-23-5 free base) | Others |
PROTAC BRD9-binding moiety 1 hydrochloride binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC. | |||
T5438 | PROTAC CDK9 Degrader-1 | CDK | |
PROTAC CDK9 Degrader-1 is a selective CDK9 degrader. | |||
T13842 | PROTAC IRAK4 degrader-1 | Others | |
PROTAC IRAK4 degrader-1 is a degrader of PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4). | |||
T11975 | PROTAC Mcl1 degrader-1 | BCL | |
PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 ... | |||
T18633 | PROTAC MDM2 Degrader-3 | Others | |
PROTAC MDM2 Degrader-3 is a compound that leverages PROTAC technology to degrade MDM2. It consists of a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1]. | |||
T13833 | PROTAC BRD4 Degrader-1 | Epigenetic Reader Domain | |
PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM). |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9784 | Docosanedioic acid | PROTAC Linker | |
BEHENIC ACID is a alkyl-chain-based PROTAC linker. BEHENIC ACID is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |