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  • PROTACs
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PROTAC

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    3393
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    5
    TargetMol | Peptide_Products
  • Dye Reagents
    1
    TargetMol | Dye_Reagents
  • PROTAC Products
    3308
    TargetMol | PROTAC
  • Natural Products
    3
    TargetMol | Natural_Products
  • Cell Research
    9
    TargetMol | Inhibitors_Agonists
FKBP12 PROTAC RC32
RC32
T136942375555-66-9
FKBP12 PROTAC RC32 is a PROTAC-like degrader targeting FKBP12. It can degrade FKBP12 in organs after intraperitoneal administration.
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7-10 days
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PROTAC-O4I2
T741862785323-62-6
PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM. PROTAC-O4I2 induced apoptosis in K562 WT cells.
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ARV-471
Vepdegestrant
T397102229711-68-4In house
Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.
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c004019
T678342417159-57-8In house
C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases.
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8-10 weeks
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Br-C10-methyl ester
T176946287-90-7
Br-C10-methyl ester, a PROTAC linker characterized by its alkyl ether composition, plays a crucial role in the synthesis of a series of PROTACs (MS432). This compound incorporates a dual-ligand system connected via a linker; notably, one ligand interacts with the VHL portion.
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Monoethyl pimelate
T1836333018-91-6
Monoethyl pimelate is a PROTAC linker, which refers to the alkyl ether composition. Monoethyl pimelate can be used in the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-XL PROTAC degrader[1].
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NH2-C4-NH-Boc
T1848568076-36-8
NH2-C4-NH-Boc (compound 15) is a PROTAC linker of the Alkyl ether class, suitable for synthesizing various PROTAC molecules.
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NH2-C6-NH-Boc
T1848751857-17-1
NH2-C6-NH-Boc is a PROTAC linker used in the synthesis of the Mcl-1 inhibitor [based on PROTAC].
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Thalidomide-5-OH
2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
T929164567-60-8
Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTAC.
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Thalidomide 5-fluoride
H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-
T9381835616-61-0
Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) is a thalidomide-based Cereblon ligand that binds to the IRAK4 protein ligand via a linker to form PROTACIRAK4 degrader-1.
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AR antagonist 1
T103591818885-54-9
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
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Azido-PEG10-alcohol
T14413877239-09-3
Azido-PEG10-alcohol, a PEG-based PROTAC linker, is utilized in PROTAC synthesis [1].
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Mal-PEG1-NHS ester
T159761807518-72-4
Mal-PEG1-NHS ester is a cleavable, PEG-based linker utilized in the synthesis of antibody-drug conjugates (ADCs) and PROTACs, serving as both an ADC linker and a PROTAC linker. [Mal-PEG1-NHS ester]
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Azido-PEG11-alcohol
T174822252392-53-1
Azido-PEG11-alcohol, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.
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Boc-NH-C4-acid
T1765327219-07-4
Boc-NH-C4-acid is a PROTAC linker of the Alkyl ether class, utilized in the synthesis of PROTAC1 for the degradation of EED, EZH2, and SUZ12 in [PRC2].
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m-PEG12-OH
Dodecaethylene Glycol Monomethyl Ether
T181432050595-03-2
m-PEG12-OH (Dodecaethylene Glycol Monomethyl Ether) is a PEG-based PROTAC linker. m-PEG12-OH can be used in the synthesis of PROTACs. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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tert-Butyl 11-aminoundecanoate
T18788220851-29-6
tert-Butyl 11-aminoundecanoate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
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Azido-PEG4-hydrazide
T144502170240-96-5
Azido-PEG4-hydrazide is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
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Biotin-PEG3-NHS ester
T145941253286-56-4
Biotin-PEG3-NHS ester is a PROTAC linker based on the PEG structure that facilitates the preparation of PROTAC.
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7-10 days
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TCO-PEG4-NHS ester
T170171613439-69-2
TCO-PEG4-NHS ester is a PROTAC linker bridge in the PEG class, used for synthesizing various PROTAC molecules. As a cleavable and synthetic ADC, it is also utilized in the synthesis of antibody-drug conjugates (ADCs).
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7-10 days
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Biotin-PEG4-Picolyl azide
T175872222687-71-8
Biotin-PEG4-Picolyl azide is a PROTAC linker belonging to the class of PEGs that can be used to synthesize PROTAC molecules.
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m-PEG12-DBCO
T18137
m-PEG12-DBCO is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker promotes selective protein degradation by utilizing the ubiquitin-proteasome system within cells.
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Benzyl-PEG12-alcohol
T396892218463-17-1
Benzyl-PEG12-alcohol is a PEG-based linker for PROTACs, connecting two essential ligands to form PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.
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7-10 days
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NH2-PEG2-C6-Cl hydrochloride
NH2-PEG2-C6-Cl hydrochloride(744203-60-9 Free base)
T40858L1035373-85-3
NH2-PEG2-C6-Cl hydrochloride is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
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