T12551 |
PROTAC BRD4 ligand-1
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Epigenetic Reader Domain
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PROTAC BRD4 ligand-1 是 PROTAC GNE-987 靶向 BRD4 蛋白的配体,也是一种 BET 的抑制剂。 |
T5835 |
PROTAC ERRα ligand 2
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Estrogen/progestogen Receptor
,
Estrogen Receptor/ERR
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PROTAC ERRα ligand 2 是雌激素相关受体 α (ERRα)反向激动剂。它对 ERRα (IC50=5.67 nM) 的抑制作用比 XCT790 (IC50=61.3 nM) 高效约 11 倍。 |
T15191 |
PROTAC ERRα ligand 1
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Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
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PROTAC ERRα ligand 1 是一种雌激素相关受体 α (ERRα) 拮抗剂,能够作用于 ERRα (IC50:0.04 μM)和 ERRγ (IC50:2.8 μM)。 |
T5437 |
Gefitinib-based PROTAC 3
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EGFR
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Gefitinib-based PROTAC 3 通过 linker 将 EGFR 结合元件与 von Hippel-Lindau 配体结合,在 HCC827(外显子 19 del)和 H3255(L858R 突变)细胞中诱导 EGFR 降... |
T13722 |
Homo-PROTAC pVHL30 degrader 1
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Others
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Homo-PROTAC pVHL30 degrader 1 是一种基于 PROTAC 的 pVHL30 降解剂。 |
T13721 |
Homo-PROTAC cereblon degrader 1
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Others
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Homo-PROTAC cereblon degrader 1 (compound 15a) 是一种高效 cereblon 降解剂,对 IKZF1 和 IKZF3 的影响很小。 |
T13848 |
SMARCA-BD ligand 1 for Protac
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Epigenetic Reader Domain
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SMARCA-BD ligand 1 for Protac 能够与 BAF ATPase 亚基 SMARCA2 结合,可用于 PROTAC 技术,用于降解 SMARCA2。 |
T8745 |
PROTAC BRAF-V600E degrader-1
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Compound 23,Compound 23 |
Raf
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PROTAC BRAF-V600E degrader-1 选择性地诱导 BRAF-V600E 的降解,而不是野生型 BRAF。 |
T13890 |
SMARCA-BD ligand 1 for Protac dihydrochloride
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Epigenetic Reader Domain
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SMARCA-BD ligand 1 for Protac dihydrochloride 是一种能够与 BAF ATPase 亚基 SMARCA2 结合的化合物,基于 PROTAC 技术,使 SMARCA2 降解。 |
T34168 |
PROTAC-I
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PROTAC I |
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PROTAC-I targets steroid hormone receptors for ubiquitination and degradation. |
T34167 |
PROTAC-12
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PROTAC12,PROTAC 12 |
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PROTAC-12 is a SirReal-based PROTAC which induces isotype-selective Sirt2 degradation, resulting in the hyperacetylation... |
T39920 |
PROTAC IRAK4 degrader-3
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PROTAC IRAK4 degrader-3 |
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PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau. |
T36242 |
PROTAC BRD4 Degrader-5
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PROTAC BRD4 Degrader-5 |
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PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive ... |
T40074 |
PROTAC BRD4 Degrader-15
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PROTAC BRD4 Degrader-15 |
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PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands ... |
T39902 |
PROTAC IRAK4 degrader-5
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PROTAC IRAK4 degrader-5 |
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PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader derived from patent US20190192668A1, compound I-171. |
T39903 |
PROTAC IRAK4 degrader-6
|
PROTAC IRAK4 degrader-6 |
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PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase... |
T39901 |
PROTAC IRAK4 degrader-4
|
PROTAC IRAK4 degrader-4 |
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PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and... |
T40073 |
PROTAC BRD4 Degrader-10
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PROTAC BRD4 Degrader-10 |
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PROTAC BRD4 Degrader-10, also known as compound 8b, is a dual ligand-based PROTAC that combines ligands for von Hippel-L... |
T40334 |
PROTAC IRAK3 degrade-1
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PROTAC IRAK3 degrade-1 |
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PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 ( IC 50 = 5 nM). |
T39997 |
PROTAC CDK9 ligand-1
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PROTAC CDK9 ligand-1 |
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PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs. |