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Search Results for " protac "

Targets

2720

Compounds

1

Natural Products

Cat No. Product Name Synonyms Targets
T12551 PROTAC BRD4 ligand-1 Epigenetic Reader Domain , Ligands for Target Protein for PROTAC
PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET.
T5835 PROTAC ERRα ligand 2 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
T15191 PROTAC ERRα ligand 1 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
PROTAC ERRα ligand 1 is an α (ERRα) antagonist of estrogen-related receptor (IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively).
T13847 PROTAC SGK3 degrader-1 SGK3-PROTAC1 SGK
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, which induces degradation of endogenous SGK3.PROTAC SGK3 degrader-1 inhibits GDC0941-induced proliferation of can...
T5437 Gefitinib-based PROTAC 3 EGFR
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectivel...
T13722 Homo-PROTAC pVHL30 degrader 1 Others , Ligand for E3 Ligase
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC.
T13848 SMARCA-BD ligand 1 for Protac Epigenetic Reader Domain
SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2
T13721 Homo-PROTAC cereblon degrader 1 Others , Ligand for E3 Ligase
Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.
T13890 SMARCA-BD ligand 1 for Protac dihydrochloride Epigenetic Reader Domain
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
T74186 PROTAC-O4I2 Apoptosis , PROTACs
PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM. PROTAC-O4I2 induced apoptosis in K562 WT cells.
T34168 PROTAC-I PROTAC I
PROTAC-I targets steroid hormone receptors for ubiquitination and degradation.
T8745 PROTAC BRAF-V600E degrader-1 Compound 23 Raf
PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.
T39901 PROTAC IRAK4 degrader-4 PROTAC IRAK4 degrader-4
PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T40073 PROTAC BRD4 Degrader-10 PROTAC BRD4 Degrader-10
PROTAC BRD4 Degrader-10, also known as compound 8b, is a dual ligand-based PROTAC that combines ligands for von Hippel-Lindau and BRD4. To degrade the BRD4 protein in PC3 prostate cancer cells, PROTAC BRD4 Degrader-10 ca...
T37329 PROTAC IDO1 Degrader-1 PROTAC IDO1 Degrader-1
PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM)...
T40334 PROTAC IRAK3 degrade-1 PROTAC IRAK3 degrade-1
PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 ( IC 50 = 5 nM).
T39997 PROTAC CDK9 ligand-1 PROTAC CDK9 ligand-1
PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.
T40075 PROTAC BRD4 Degrader-13 PROTAC BRD4 Degrader-13
PROTAC BRD4 Degrader-13 (compound 9d) is a bioactive compound that functions as a proteolysis targeting chimera (PROTAC), linking ligands for von Hippel-Lindau and BRD4 proteins. In the context of PC3 prostate cancer cel...
T39996 PROTAC CDK9 degrader-4 PROTAC CDK9 degrader-4
PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9...
T36242 PROTAC BRD4 Degrader-5 PROTAC BRD4 Degrader-5
PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].
T39920 PROTAC IRAK4 degrader-3 PROTAC IRAK4 degrader-3
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.
T39902 PROTAC IRAK4 degrader-5 PROTAC IRAK4 degrader-5
PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader.
T40074 PROTAC BRD4 Degrader-15 PROTAC BRD4 Degrader-15
PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BR...
T39903 PROTAC IRAK4 degrader-6 PROTAC IRAK4 degrader-6
PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T18629 PEG3-O-CH2COOH PROTAC Linker 8 Others , PROTAC Linker
PEG3-O-CH2COOH (PROTAC Linker 8) (PROTAC Linker 8) is a PEG-based PROTAC linker. PEG3-O-CH2COOH can be used in the synthesis of SNIPERs.
T39628 PROTAC BRD4 ligand-2 PROTAC BRD4 ligand-2
PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718.
T40072 PROTAC BRD4 Degrader-9 PROTAC BRD4 Degrader-9
PROTAC BRD4 Degrader-9 (compound 8a) is a novel chemical compound consisting of ligands for von Hippel-Lindau and BRD4, connected by a PROTAC moiety. This compound can effectively degrade the BRD4 protein in PC3 prostate...
T36628 PROTAC BRD4 Degrader-8 PROTAC BRD4 Degrader-8
PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells...
T18617 NH2-C5-NH-Boc PROTAC Linker 23 Others , PROTAC Linker
NH2-C5-NH-Boc (PROTAC Linker 23) (PROTAC Linker 23) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
T18639 Cl-C6-PEG4-O-CH2COOH PROTAC Linker 4 Others
Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is an effective pegylated PROTAC linker, which is often used in PROTAC synthesis of chloroanes (HaloPROTACs).
T7701 Boc-NH-PEG3 PROTAC Linker 10 Others , PROTAC Linker
Boc-NH-PEG3 (PROTAC Linker 10) is a PEG derivative containing a hydroxyl group and Boc-protected amino group, and is a PROTAC linker.
T18616 NH2-C2-NH-Boc PROTAC Linker 22 Others , PROTAC Linker
NH2-C2-NH-Boc (PROTAC Linker 22) (PROTAC Linker 22) is a alkyl chain-based PROTAC linker. NH2-C2-NH-Boc can be used in the synthesis of PROTACs.
T40143 PROTAC CBP/P300 Degrader-1 PROTAC CBP/P300 Degrader-1
PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.
T32043 HaloPROTAC3 Halo PROTAC-3,HaloPROTAC 3,HaloPROTAC-3 Ligand for E3 Ligase
HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.
T40112 PROTAC PD-1/PD-L1 degrader-1 PROTAC PD-1/PD-L1 degrader-1
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppr...
T39837 PROTAC ERRα Degrader-3
PROTAC ERRα Degrader-3 is a highly effective and selective von Hippel-Lindau-based ligand that efficiently degrades the ERRα protein. At a concentration of 30 nM, this compound exhibits a remarkable degradation capabilit...
T39374 PROTAC BET Degrader-10
PROTAC BET Degrader-10 (WO2017007612A1, example 37) is a highly efficient and selective small molecule compound designed to degrade BET protein BRD4. PROTAC BET Degrader-10 functions by utilizing specific ligands that co...
T18595 Dasatinib carbaldehyde PROTAC ABL binding moiety 4,BMS-354825 carbaldehyde Others , Ligands for Target Protein for PROTAC
Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) is based on Dasatinib which is an ABL inhibitor, binds to the IAP ligand via a linker, and forms SNIPER [1].
T36243 PROTAC RIPK degrader-6
PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder[1]. PROTACs is useful for the targeted degradation of proteins...
T36256 LC-2 LC 2,PROTAC KRASG12C Degrader-LC-2,LC2 PROTACs
LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recru...
T13845 PROTAC PARP1 degrader Others
PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μM).
T36247 TBK1 control PROTAC® 4
Negative control for TBK1 PROTAC 3i. Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
T41267 PROTAC(H-PGDS)-7
PROTAC(H-PGDS)-7 is a selective and potent small molecule hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degradation agent that exhibits degradation activity in KU812 cells with a DC50 of 17.3 pM. PROTAC(H-PGDS)-...
T17995 Halo PROTAC 1 Others
Halo PROTAC 1 is a PROTAC, which is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce autophagy of an intracellular molecule are linked via a PEG l...
T13915L PROTAC BRD9-binding moiety 1 hydrochloride PROTAC BRD9-binding moiety 1 hydrochloride (2097512-23-5 free base) Others
PROTAC BRD9-binding moiety 1 hydrochloride binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
T5438 PROTAC CDK9 Degrader-1 CDK
PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
T13842 PROTAC IRAK4 degrader-1 Others
PROTAC IRAK4 degrader-1 is a degrader of PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4).
T11975 PROTAC Mcl1 degrader-1 BCL
PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 ...
T18633 PROTAC MDM2 Degrader-3 Others
PROTAC MDM2 Degrader-3 is a compound that leverages PROTAC technology to degrade MDM2. It consists of a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].
T13833 PROTAC BRD4 Degrader-1 Epigenetic Reader Domain
PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).

Compounds

PROTAC BRD4 ligand-1
T12551
Synonym:
Target: Epigenetic Reader Domain, Ligands for Target Protein for PROTAC
PROTAC ERRα ligand 2
T5835
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
PROTAC ERRα ligand 1
T15191
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
PROTAC SGK3 degrader-1
T13847
Synonym: SGK3-PROTAC1
Target: SGK
Gefitinib-based PROTAC 3
T5437
Synonym:
Target: EGFR
Homo-PROTAC pVHL30 degrader 1
T13722
Synonym:
Target: Others, Ligand for E3 Ligase
SMARCA-BD ligand 1 for Protac
T13848
Synonym:
Target: Epigenetic Reader Domain
Homo-PROTAC cereblon degrader 1
T13721
Synonym:
Target: Others, Ligand for E3 Ligase
SMARCA-BD ligand 1 for Protac dihydrochloride
T13890
Synonym:
Target: Epigenetic Reader Domain
PROTAC-O4I2
T74186
Synonym:
Target: Apoptosis, PROTACs
PROTAC-I
T34168
Synonym: PROTAC I
Target:
PROTAC BRAF-V600E degrader-1
T8745
Synonym: Compound 23
Target: Raf
PROTAC IRAK4 degrader-4
T39901
Synonym: PROTAC IRAK4 degrader-4
Target:
PROTAC BRD4 Degrader-10
T40073
Synonym: PROTAC BRD4 Degrader-10
Target:
PROTAC IDO1 Degrader-1
T37329
Synonym: PROTAC IDO1 Degrader-1
Target:
PROTAC IRAK3 degrade-1
T40334
Synonym: PROTAC IRAK3 degrade-1
Target:
PROTAC CDK9 ligand-1
T39997
Synonym: PROTAC CDK9 ligand-1
Target:
PROTAC BRD4 Degrader-13
T40075
Synonym: PROTAC BRD4 Degrader-13
Target:
PROTAC CDK9 degrader-4
T39996
Synonym: PROTAC CDK9 degrader-4
Target:
PROTAC BRD4 Degrader-5
T36242
Synonym: PROTAC BRD4 Degrader-5
Target:
PROTAC IRAK4 degrader-3
T39920
Synonym: PROTAC IRAK4 degrader-3
Target:
PROTAC IRAK4 degrader-5
T39902
Synonym: PROTAC IRAK4 degrader-5
Target:
PROTAC BRD4 Degrader-15
T40074
Synonym: PROTAC BRD4 Degrader-15
Target:
PROTAC IRAK4 degrader-6
T39903
Synonym: PROTAC IRAK4 degrader-6
Target:
PEG3-O-CH2COOH
T18629
Synonym: PROTAC Linker 8
Target: Others, PROTAC Linker
PROTAC BRD4 ligand-2
T39628
Synonym: PROTAC BRD4 ligand-2
Target:
PROTAC BRD4 Degrader-9
T40072
Synonym: PROTAC BRD4 Degrader-9
Target:
PROTAC BRD4 Degrader-8
T36628
Synonym: PROTAC BRD4 Degrader-8
Target:
NH2-C5-NH-Boc
T18617
Synonym: PROTAC Linker 23
Target: Others, PROTAC Linker
Cl-C6-PEG4-O-CH2COOH
T18639
Synonym: PROTAC Linker 4
Target: Others
Boc-NH-PEG3
T7701
Synonym: PROTAC Linker 10
Target: Others, PROTAC Linker
NH2-C2-NH-Boc
T18616
Synonym: PROTAC Linker 22
Target: Others, PROTAC Linker
PROTAC CBP/P300 Degrader-1
T40143
Synonym: PROTAC CBP/P300 Degrader-1
Target:
HaloPROTAC3
T32043
Synonym: Halo PROTAC-3,HaloPROTAC 3,HaloPROTAC-3
Target: Ligand for E3 Ligase
PROTAC PD-1/PD-L1 degrader-1
T40112
Synonym: PROTAC PD-1/PD-L1 degrader-1
Target:
PROTAC ERRα Degrader-3
T39837
Synonym:
Target:
PROTAC BET Degrader-10
T39374
Synonym:
Target:
Dasatinib carbaldehyde
T18595
Synonym: PROTAC ABL binding moiety 4,BMS-354825 carbaldehyde
Target: Others, Ligands for Target Protein for PROTAC
PROTAC RIPK degrader-6
T36243
Synonym:
Target:
LC-2
T36256
Synonym: LC 2,PROTAC KRASG12C Degrader-LC-2,LC2
Target: PROTACs
PROTAC PARP1 degrader
T13845
Synonym:
Target: Others
TBK1 control PROTAC® 4
T36247
Synonym:
Target:
PROTAC(H-PGDS)-7
T41267
Synonym:
Target:
Halo PROTAC 1
T17995
Synonym:
Target: Others
PROTAC BRD9-binding moiety 1 hydrochloride
T13915L
Synonym: PROTAC BRD9-binding moiety 1 hydrochloride (2097512-23-5 free base)
Target: Others
PROTAC CDK9 Degrader-1
T5438
Synonym:
Target: CDK
PROTAC IRAK4 degrader-1
T13842
Synonym:
Target: Others
PROTAC Mcl1 degrader-1
T11975
Synonym:
Target: BCL
PROTAC MDM2 Degrader-3
T18633
Synonym:
Target: Others
PROTAC BRD4 Degrader-1
T13833
Synonym:
Target: Epigenetic Reader Domain
1 2 3 4 5 ... 55
Cat No. Product Name Synonyms Targets
T9784 Docosanedioic acid  PROTAC Linker
BEHENIC ACID is a alkyl-chain-based PROTAC linker. BEHENIC ACID is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
TargetMol