alt

ALT-100 (HumanIgG4) is a human-derived antibody expressed in CHO cells, targeting NAMPT. It consists of a huIgG1/huIgG4 heavy chain and a huκ light chain, with an estimated molecular weight (MW) of 150 kDa. For inflammation or fibrotic diseases, the isotype control for ALT-100 (HumanIgG4) is HumanIgG4(S228P) kappa, Isotype Control. For other indications, refer to HumanIgG1kappa, Isotype Control for the isotype control of ALT-100.

Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor that has proven effective in reducing systolic blood pressure and providing therapeutic benefits for patients with diastolic.

Inbakicept is a dimer of IL-15 receptor alpha sushi domain and immunoglobulin G1 (human Fc fragment) fusion protein, which is an IL-15 super agonist protein complex. Inbakicept binds to IL-15 antibody Nogapendekin alfa to form the complex Nogapendekin alfa inbakicept (ALT-803) in a 1:2 ratio. ALT-803 has potential anticancer and anti-tumor activities, which can be used to study breast cancer.

Oregovomab is a highly specialized murine monoclonal antibody target the tumor-associated antigen CA125 (MUC16), induction of robust anti-idiotypic antibody responses and T-cell mediated anti-tumor immunity by forming immune complexes across various preclinical experimental models.

Berahyaluronidase alfa is a recombinant human hyaluronidase that temporarily increases tissue permeability by degrading hyaluronan in the extracellular matrix, thereby facilitating the absorption and dispersion of co-administered subcutaneous drugs like pembrolizumab. Its application significantly enhances the bioavailability of large-molecule biologics via the subcutaneous route, enabling the transition from intravenous to more convenient subcutaneous delivery.

ALT-007 is an orally bioavailable inhibitor of serine palmitoyltransferase (SPT), the rate-limiting enzyme in de novo ceramide synthesis. In murine models of age-related sarcopenia, ALT-007 effectively restores muscle mass and function impaired by aging. Additionally, ALT-007 may enhance protein homeostasis in Caenorhabditis elegans and in mouse models of aging and age-associated diseases, acting as a ceramide inhibitor.

ALT-946 free base is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat.

ALT-946 HCl is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat.

ALT-836 (TNX-832) is a humanized monoclonal antibody targeting tissue factor (TF). It binds specifically to TF and blocks the activity of the TF-FVIIa complex, thereby inhibiting the coagulation cascade and showing anti-tumor and anti-inflammatory potential.

ALT-100 (Human IgG1) is a humanized IgG1 monoclonal neutralizing antibody targeting extracellular nicotinamide phosphoribosyltransferase (eNAMPT). This product binds specifically to eNAMPT, blocking its function as a damage-associated molecular pattern (DAMP) that induces pro-inflammatory and pro-fibrotic signaling. ALT-100 effectively inhibits eNAMPT-mediated TLR4 activation, reduces the release of inflammatory cytokines, and suppresses tissue remodeling. It serves as an important pharmacological tool for researching post-infarct myocardial fibrosis, acute respiratory distress syndrome (ARDS), and systemic inflammatory response syndrome.

Poly(methyl vinyl ether-alt-maleic anhydride) (MW 216000) is applicable in the preparation of antibacterial hydrogels that exhibit excellent mechanical strength and exceptional swelling capacity.

Poly(methyl vinyl ether-alt-maleic anhydride) (MW 1080000) is suitable for preparing antibacterial hydrogels that exhibit excellent mechanical strength and swelling capacity.

Methicillin sodium salt is the sodium salt form of methicillin, a semisynthetic beta-lactam penicillin antibiotic with beta-lactamase resistant activity.

Durlobactam sodium salt (ETX2514) is a beta-lactamase inhibitor with IC50 values of 4 nM, 14 nM and 190 nM against class A KPC-2, class C AmpC and class D OXA-24.

Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.

Nigericin sodium salt is an antibiotic, an NLRP3 activator, and a cationic ion carrier. Nigericin sodium triggers the activation of the NALP3 inflammasome, which inhibits Golgi function and suppresses the growth of Gram-positive bacteria.

Selvigaltin (GB1211) is a Gal-3 inhibitor with potential anticancer activity. Selvigaltin is used in the study of cirrhosis and cancer.

Tirzepatide sodium salt (LY3298176 sodium salt) is a GIP and GLP-1 receptor agonist with neuroprotective activity and can be used to treat obesity.

BzATP triethylammonium salt is a P2X7 receptor agonist.

CHPG sodium salt is a selective agonist of mGluR5 that activates ERK and Akt signaling pathways and is utilized in studies on traumatic brain injury.

Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.

PSB-12379 ditriethylamine salt, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).

SDZ 220-581 Ammonium salt is a potent, orally active, and competitive NMDA receptor antagonist (pKi: 7.7).

Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.