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  • Inhibitors & Agonists
    478
    TargetMol | Inhibitors_Agonists
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Tizaterkib
AZD-0364
T104292097416-76-5
Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.
  • $96
In Stock
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QTY
erk5-in-1
T51841234479-76-5
ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM) and also inhibits LRRK2[G2019S] (IC50: 26 nM).
  • $48
In Stock
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PAF (C16)
C16-PAF
T2154774389-68-7In house
PAF (C16) is a potent MAPK and MEK ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled receptor (PAFR). PAF (C16) has shown anti-apoptotic and anti-inflammatory activity in vitro, inhibiting Caspase-dependent apoptosis by interacting with its receptor (PAF-R) to perform cell signaling.
  • $69
In Stock
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QTY
TargetMol | Inhibitor Hot
Ro-3306
T2356872573-93-8
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases.
  • $32
In Stock
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TargetMol | Inhibitor Hot
Tauroursodeoxycholate
Ursodeoxycholyltaurine, UR 906, TUDCA, Tauroursodeoxycholic Acid, Taurolite
T253214605-22-2
Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans.Tauroursodeoxycholate is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.
  • $37
In Stock
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TargetMol | Inhibitor Hot
PD98059
PD 98059
T2623167869-21-8
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2 50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy.
  • $34
In Stock
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TargetMol | Inhibitor Hot
SCH772984
T6066942183-80-4
SCH772984 is an ERK inhibitor that inhibits ERK1 and ERK2 (IC50=4 1 nM) and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity against BRAF or RAS mutant cells.
  • $48
In Stock
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TargetMol | Inhibitor Hot
MK-8353
SCH900353
T120691184173-73-6In house
MK-8353 (SCH900353) is a potent, selective, and orally available inhibitor of ERK1 2 with IC50 values of 23.0 nM and 8.8 nM, respectively.
  • $74 TargetMol
In Stock
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Olomoucine
T21588101622-51-9In house
Olomoucine is an ATP-competitive inhibitor of Cdk2 cyclin A, Cdc2 CyclinB, CDK2 CyclinE, CDK5 p35, and ERK1 p44 MAP kinase with IC50s of 7, 7, 7, 3, and 25 µM, respectively. It regulates the cell cycle and exhibits anti-melanin tumor activities.
  • $60
In Stock
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Honokiol
NSC 293100
T300135354-74-6
Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1 ERK2.
  • $50
In Stock
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Galangin
Norizalpinin, 3,5,7-Trihydroxyflavone
T3668548-83-4
Galangin (Norizalpinin) is an agonist antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
  • $30
In Stock
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2,5-Dihydroxyacetophenone
Quinacetophenone, DHAP, Acetylhydroquinone, 2-Acetylhydroquinone, 2-5-dihydroxyacetophenone
TCS2170490-78-8
1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1 2, and p38 MAPKs, it also can potentiate the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells. 3. 2,5-Dihydroxyacetophenone (Quinacetophenone) has anti-inflammatory activity in activated macrophages, raising the possibility that this compound has a therapeutic potential for inflammatory conditions. 4. 2,5-Dihydroxyacetophenone (Quinacetophenone) is an uncompetitive inhibitor of murine tyrosinase (K(I) 0.28mm), it strongly inhibits both melanogenesis and cellular tyrosinase activity in vitro in 3-isobutyl-1-methylxanthin-stimulated B16 mouse melanoma cells or in vivo in zebrafish and mouse models.
  • $37
In Stock
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trans-Zeatin
(E)-Zeatin
TMS21811637-39-4
trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing.
  • $33
In Stock
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FR 180204
FR180204
T1956865362-74-9
FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.
  • $36
In Stock
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Ravoxertinib
GDC-0994
T65111453848-26-4
Ravoxertinib (GDC-0994) is an efficacious, orally available ERK1 2 inhibitor with an IC50 of 1.1 0.3 nM.
  • $34
In Stock
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BAY885
T104792307249-33-6
BAY885 is a new ERK5 inhibitor.
  • $46
In Stock
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Tauroursodeoxycholate dihydrate
UR 906 dihydrate, TUDCA dihydrate, Tauroursodeoxycholic acid dihydrate, Taurolite dihydrate
T16998117609-50-4
Tauroursodeoxycholate (TUDCA ,Taurolite) dihydrate is a water-soluble bile acid with endoplasmic reticulum stress inhibitory, mitochondrial stabilizing, and anti-apoptotic effects, which significantly reduces the expression of apoptotic molecules, such as Caspase-3 and Caspase-12, and inhibits ERK, reducing endoplasmic reticulum stress mediated cell death.
  • $35
In Stock
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xmd17-109
XMD17 109, ERK5-IN-1
T18421435488-37-1
XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).
  • $35
In Stock
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XMD8-92
T18431234480-50-2
XMD8-92 is an effective and specific BMK1 ERK5 inhibitor (Kd: 80 nM).
  • $48
In Stock
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TargetMol | Inhibitor Sale
bix02189
BIX 02189
T212951265916-41-3
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5 (IC50: 1.5 nM and 59 nM).
  • $29
In Stock
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VX-11e
VTX-11e, Vertex-11e, TCS ERK 11e
T3166896720-20-0
VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.
  • $50
In Stock
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TargetMol | Inhibitor Sale
Bongkrekic acid
Bongkrek Acid
T3606711076-19-0
Bongkrekic acid (Bongkrekic Acid (ammonium salt)) is a mitochondrial toxin secreted by Burkholderia gladioli that inhibits adenine nucleotide translocase (ANT).Bongkrekic acid Bongkrekic acid Bongkrekic acid induces extracellular traps in neutrophils through signaling mediated by p38, ERK, PAD4, and P2X1.
  • $1,790
7-10 days
Size
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12(S)-HETE
12S-HETE
T3704754397-83-0
12(S)-HETE, a 12-lipoxygenase metabolite of arachidonic acid, is mitogenic for cancer cell proliferation and enhances angiotensin II-induced contraction of BLT2 (type 2 receptor in arteries of leukotriene B4 mice) and TP (thromboxane receptor)-mediated mechanisms. 12(S)-HETE promotes superoxide and isothromboxane-like metabolites in arterial endothelial cells. production.
  • $642
In Stock
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Deltonin
T384455659-75-1
Deltonin has an inhibition of ERK1 2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM), mouse C26 cells (IC50: 1.22 μM), and human MDA-MB-231 cells (IC50: 1.58 μM).
  • $98
In Stock
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