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Search Results for " cox "

Targets

481

Compounds

24

Recombinant Proteins

1

Libraries

Cat No. Product Name
T10033 COX-2-IN-1 COX
COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).
T10032 COX-2-IN-2 COX
COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC50 of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compo...
T77618 COX-2-IN-34 COX
COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer to...
T62061 COX-2-IN-6 COX , Prostaglandin Receptor
COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a...
T6574 Lumiracoxib Prexige,COX-189 COX
Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold s...
T7207 FK 3311 FK-3311,COX-2 Inhibitor V COX
FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and no...
T13263 COX/5-LO-IN-1 Atreleuton analog COX
COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease st...
T79760 COX-2-IN-35 COX
COX-2-IN-35 (compound 7) is a selective inhibitor of COX-2, demonstrating anti-inflammatory activity, with an inhibitory...
T62175 COX-2-IN-8
COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 sele...
T61264 COX-2-IN-19
COX-2-IN-19 (Compound 24) is a highly potent inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 1.76 μM. Notabl...
T61714 COX-2-IN-13
COX-2-IN-13 (compound 13e) is a highly potent and selective inhibitor of COX-2, demonstrating a remarkable IC50 value of...
T62350 XO/COX/LOX-IN-1
XO/COX/LOX-IN-1 is a potent inhibitor of xanthine oxidase/cyclooxygenase/lipoxygenase XO/COX/LOX. XO/COX/LOX-IN-1 can be...
T79594 COX-1/2-IN-5 COX
COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2....
T78706 COX-2-IN-31 COX
COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). Addit...
T78705 COX-2-IN-30 COX
COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 ...
T64109 COX-2-IN-28
COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM...
T63943 COX-2-IN-10
COX-2-IN-10 is a potent inhibitor of COX-2. COX-2-IN-10 exhibits inhibitory effects on the production of IL-6, TNF-α and...
T60457 COX-2-IN-11
COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation dise...
T63646 COX-2-IN-9
COX-2-IN-9 is a selective, potent, orally active COX-2 inhibitor (IC50: 10.17 μM).COX-2-IN-9 has a higher COX-2 selectiv...
T62259 COX-2-IN-21
COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inf...
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Cat No. Product Name Species Source
TMPY-01736 COX-2 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is overexpressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression ...
TMPY-04807 Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein (Fc) CV Baculovirus-Insect Cells
TMPY-04908 Coxsackievirus A16 (Cox A16) (strain G-10) VP1 Protein (Fc) CV Baculovirus-Insect Cells
TMPY-02481 ACOX1 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a...
TMPY-03511 COX5B Protein, Human, Recombinant (His) Human E. coli
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nucl...
TMPY-03752 COX4NB Protein, Human, Recombinant (His) Human E. coli
TMPJ-00778 HER2 Protein, Human, Recombinant (His) Human Human Cells
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 incr...
TMPY-02886 IL-17 Protein, Human, Recombinant Human E. coli
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocyt...
TMPY-02900 IL-17 Protein, Mouse, Recombinant Mouse E. coli
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocyt...
TMPY-03658 ETHE1 Protein, Human, Recombinant (His) Human E. coli
ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. ETHE1 can suppresses p53-induced apoptosis by preventing nuclear localization of RELA. Mutations in ETHE1 gene result in ethylmalonic encephalopathy. Ethylmalonic en...
TMPJ-00704 SCO1 Protein, Human, Recombinant (GST) Human E. coli
Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by high rates of Oxidative Phosphorylation (OxPhos). SCO1 is thought to play a important role in cellular copper homeostasis, mitochondrial redox signaling and insertion of copper into the active site of COX. The defects of SCO1 can result in Mitochondrial Complex IV Deficiency (MT-C4...
TMPJ-00777 HER2 Protein, Human, Recombinant (hFc) Human Human Cells
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 incr...
TMPJ-00776 HER2 Protein, Human, Recombinant (hFc & Avi), Biotinylated Human Human Cells
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 incr...
TMPY-04023 BCCIP Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations may overcome the progression suppression imposed by BCCIP deficiency through a synthetic viability mechanism. Knockdown of YY1 inhibited the binding of BCCIP itself at BCCIP promoter region proximal to TSS, demonstrating that transcriptional regulation of the YY1 on BCCIP can be ...
TMPY-00578 BCCIP Protein, Human, Recombinant Human Baculovirus-Insect Cells
BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations may overcome the progression suppression imposed by BCCIP deficiency through a synthetic viability mechanism. Knockdown of YY1 inhibited the binding of BCCIP itself at BCCIP promoter region proximal to TSS, demonstrating that transcriptional regulation of the YY1 on BCCIP can be ...
TMPY-04710 IL-17 Protein, Rhesus, Recombinant Rhesus Baculovirus-Insect Cells
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocyt...
TMPY-03568 IL-17 Protein, Human, Recombinant (His) Human Yeast
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocyt...
TMPY-04888 IL-17 Protein, Rabbit, Recombinant Rabbit E. coli
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocyt...
TMPY-05342 IL-17 Protein, Cynomolgus, Recombinant Cynomolgus Baculovirus-Insect Cells
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocyt...
TMPY-04609 IL-17 Protein, Rabbit, Recombinant (His) Rabbit Baculovirus-Insect Cells
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocyt...

Recombinant Proteins

COX-2 Protein, Human, Recombinant (His)
TMPY-01736
Species: Human
Source: Baculovirus-Insect Cells
Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein (Fc)
TMPY-04807
Species: CV
Source: Baculovirus-Insect Cells
Coxsackievirus A16 (Cox A16) (strain G-10) VP1 Protein (Fc)
TMPY-04908
Species: CV
Source: Baculovirus-Insect Cells
ACOX1 Protein, Human, Recombinant (His)
TMPY-02481
Species: Human
Source: Baculovirus-Insect Cells
COX5B Protein, Human, Recombinant (His)
TMPY-03511
Species: Human
Source: E. coli
COX4NB Protein, Human, Recombinant (His)
TMPY-03752
Species: Human
Source: E. coli
HER2 Protein, Human, Recombinant (His)
TMPJ-00778
Species: Human
Source: Human Cells
IL-17 Protein, Human, Recombinant
TMPY-02886
Species: Human
Source: E. coli
IL-17 Protein, Mouse, Recombinant
TMPY-02900
Species: Mouse
Source: E. coli
ETHE1 Protein, Human, Recombinant (His)
TMPY-03658
Species: Human
Source: E. coli
SCO1 Protein, Human, Recombinant (GST)
TMPJ-00704
Species: Human
Source: E. coli
HER2 Protein, Human, Recombinant (hFc)
TMPJ-00777
Species: Human
Source: Human Cells
HER2 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPJ-00776
Species: Human
Source: Human Cells
BCCIP Protein, Human, Recombinant (His & GST)
TMPY-04023
Species: Human
Source: Baculovirus-Insect Cells
BCCIP Protein, Human, Recombinant
TMPY-00578
Species: Human
Source: Baculovirus-Insect Cells
IL-17 Protein, Rhesus, Recombinant
TMPY-04710
Species: Rhesus
Source: Baculovirus-Insect Cells
IL-17 Protein, Human, Recombinant (His)
TMPY-03568
Species: Human
Source: Yeast
IL-17 Protein, Rabbit, Recombinant
TMPY-04888
Species: Rabbit
Source: E. coli
IL-17 Protein, Cynomolgus, Recombinant
TMPY-05342
Species: Cynomolgus
Source: Baculovirus-Insect Cells
IL-17 Protein, Rabbit, Recombinant (His)
TMPY-04609
Species: Rabbit
Source: Baculovirus-Insect Cells
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TargetMol