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ODN 2088
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Catalog No. T64278Cas No. 1146541-45-8
Alias ODN2088
ODN 2088 is an effective Toll-like receptor inhibitor exhibiting significant inhibitory activity against TLR3, TLR7, and TLR9 without cytotoxicity. It reduces IFN-α and IL-6 release by blocking associated innate immune signaling pathways. In vitro experiments demonstrated that ODN 2088 (0.01–10 μM, 48 hours) showed minimal inhibition of IL-6 release induced by CpG-ODN 2006 (100 nM), but markedly suppressed IL-6 secretion from human peripheral blood mononuclear cells stimulated by imiquimod (5 μg/mL). This demonstrates its differential regulatory potential across distinct TLR activation pathways.
ODN 2088
Copy Product Info😃Good
Catalog No. T64278Alias ODN2088Cas No. 1146541-45-8
ODN 2088 is an effective Toll-like receptor inhibitor exhibiting significant inhibitory activity against TLR3, TLR7, and TLR9 without cytotoxicity. It reduces IFN-α and IL-6 release by blocking associated innate immune signaling pathways. In vitro experiments demonstrated that ODN 2088 (0.01–10 μM, 48 hours) showed minimal inhibition of IL-6 release induced by CpG-ODN 2006 (100 nM), but markedly suppressed IL-6 secretion from human peripheral blood mononuclear cells stimulated by imiquimod (5 μg/mL). This demonstrates its differential regulatory potential across distinct TLR activation pathways.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 25 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:White
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| Description | ODN 2088 is an effective Toll-like receptor inhibitor exhibiting significant inhibitory activity against TLR3, TLR7, and TLR9 without cytotoxicity. It reduces IFN-α and IL-6 release by blocking associated innate immune signaling pathways. In vitro experiments demonstrated that ODN 2088 (0.01–10 μM, 48 hours) showed minimal inhibition of IL-6 release induced by CpG-ODN 2006 (100 nM), but markedly suppressed IL-6 secretion from human peripheral blood mononuclear cells stimulated by imiquimod (5 μg/mL). This demonstrates its differential regulatory potential across distinct TLR activation pathways. |
| In vitro | ODN 2088 (0.001, 0.01, 0.1, 1, 10 μM; 24 hours) dose-dependently inhibited TNF-α secretion in CpG-ODN 1826 (100 nM)-stimulated BMDMs and exhibited weekly inhibitory effects when stimulated with the TLR7 agonist imiquimod [3]. |
| Synonyms | ODN2088 |
| Cas No. | 1146541-45-8 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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