b-10

Boronophenylalanine B-10 (BPA) is a boron delivery agent used in boron neutron capture therapy (BNCT) for the treatment of metastatic melanoma and other tumors.

Phenethyl trans-cinnamate is an aromatic ester found in various plants. It is an important intermediate in the synthesis of various drugs and spices, and is also used in the synthesis of various flavors, fragrances and cosmetics.

Rapavir (JH-B10) is a selective and potent inhibitor of sodium taurocholate co-transporting polypeptide (NTCP), with an IC50 value of 1.8 nM for taurocholic acid-d4 (TCA-d4) uptake. It exhibits antiviral activity against HBV infection by directly binding to NTCP and preventing the virus from entering cells. Rapavir is promising for HBV infection research.

B10-S is a potent anti-allergenic agent that inhibits LAD2 degranulation induced by P substances.

LX-4 is a selective activator of the p38 mitogen-activated protein kinase (MAPK) pathway. LX-4 de-represses a subset of endogenous genes repressed by DNA methylation.

84-B10 protects against cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors, inhibiting mitochondrial damage and mtROS production, and restoring superoxide dismutase to reduce cisplatin-induced kidney damage.

CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.

LM22B-10, an activator of the TrkB/TrkC neurotrophin receptor, can induce activation of TrkB, TrkC, ERK, and AKT both in vitro and in vivo.

BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3, which may be useful in the study of macular degeneration and diseases associated with genetic disorders and malformations.

(Rac)-LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation

DB-10 serves as a precursor to 3-nbutylphthalide (NBP). It is absorbed by cells in a temperature and energy-dependent manner through the pyrilamine cation transporter. DB-10 enhances cell survival and rapidly converts into an active form in vivo, increasing accumulation within the brain. This compound is applicable in ischemic stroke research.

PSB-10 hydrochloride is a human adenosine A3 receptor antagonist.

ALB-109564 dihydrochloride is a semi-synthetic derivative of the vinka alkaloid vinblastine with potential antineoplastic activity, a microtubule protein inhibitor and antineoplastic compound. It binds to tubulin monomers and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the G2/M phase of the cell cycle.

B 1056 is a bioactive chemical.

PSB-10211 is a potent competitive antagonist and positive modulator of the P2X2 receptor.

BDB-108 is a re-activator of isopropyl-methylphosphonylated acetylcholinesterase.

IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.

MFB-1041 is an orally effective antifungal agent with poor oral absorption. It induces drug binding with serum albumin.

HB-107 is a peptide known for its wound healing properties. This compound promotes keratinocyte proliferation and increased leukocyte infiltration at the wound site. Additionally, HB-107 stimulates the secretion of interleukin 8 (IL-8) in cultured endothelial cells. It holds promise for research in wound healing and inflammation.

CalB-10Xup (Candida antarcticalipase) is a biocatalyst and a crucial enzyme in new biocatalysis technology. Enzyme engineering focuses on improving the enzyme's reaction kinetics, substrate selectivity, and activity under harsh conditions (such as low or high pH). The introduction of stimuli-responsive modifications allows for dynamic control of these enzymes' activity.

CalB-10X, also known as Candida antarctica lipase B (CALB), functions as a catalyst for polymer synthesis.

LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.

ATB107 hydrochloride is a novel and potent inhibitor of indole-3-glycerol phosphate synthase (IGPS) with a KD of 3 μM.

Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.