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Results for "ERK" in TargetMol Product Catalog
  • Inhibitor Products
    285
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CK2/ERK8-IN-1
T108271085822-09-8In house
CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM).
  • $30
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ERK5-IN-6
T777312734916-64-2
ERK5-IN-6 is a potent inhibitor of ERK5 kinase.ERK5-IN-6 exhibits antiproliferative activity, anticonvulsant activity, and antitumor activity, and can be used in the study of central nervous system-related disorders.
  • $195
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ERK-IN-2
T112252743576-56-7
ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1].
  • $1,520
10-14 weeks
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TargetMol | Citations Cited
ERK-CLIPTAC
T824432087490-46-6
ERK-CLIPTAC is a PROTAC (PROteolysis TArgeting Chimera) molecule designed to induce the degradation of Extracellular signal-Regulated Kinase (ERK) [1].
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ERK5-IN-5
T777342318792-30-0
ERK5-IN-5 is a potent extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity and potential anticonvulsant activity that inhibits A549 cell proliferation.
  • $78
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ERK-IN-4
T366751049738-54-6
ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.
  • $40
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ERK1/2 inhibitor 4
T743742490396-99-9
ERK1/2 Inhibitor 5, a potent suppressant of the ERK1/2 pathway, is instrumental in the mitogen-activated protein kinase (MAPK) signal transduction pathway, where extracellular signal-regulated kinase (ERK) serves as a critical component of the MAPK family. This compound holds promise for the investigation or mitigation of cancer, inflammation, or various proliferative diseases[1].
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Rineterkib
T112241715025-32-3
Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
  • $96
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TargetMol | Citations Cited
ERK1/2 inhibitor 8
T633312648368-43-6
ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).
  • $2,140
8-10 weeks
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VX-11e
T3166896720-20-0
VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.
  • $50
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ERK-IN-3
T91412055597-12-9
ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations.
  • $56
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ERK5-IN-2
T55351888305-96-1
ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.
  • $41
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ERK-IN-3 benzenesulfonate
T394532055597-39-0
ERK-IN-3 benzenesulfonate is a potent and orally active inhibitor of ERK . ERK-IN-3 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC 50 values. ERK-IN-3 benzenesulfonate can be used for the research of cancers driven by RAS mutations.
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    ERK5-IN-1
    T51841234479-76-5
    ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).
    • $48
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    ERK-IN-2 free base
    T725172743576-55-6
    ERK-IN-2 free base, an inhibitor of ERK2, demonstrates potent efficacy with an IC50 value of 1.8 nM. However, doses exceeding 10 μM may result in off-target toxicity and/or activity.
    • $1,970
    8-10 weeks
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    ERK Inhibitor II (Negative control)
    T713161177970-73-8
    ERK Inhibitor II (Negative control) effectively blocks extracellular signal-regulated kinase (ERK) and interferes with insulin receptor activation, serving as a useful tool in diabetes research.
    • $1,820
    8-10 weeks
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    ERK1/2 inhibitor 7
    T629332648455-13-2
    ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).
    • $1,400
    8-10 weeks
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    STE-MEK1(13)
    T80543566872-15-9
    STE-MEK1(13), a cell-permeable ERK1/2 inhibitor with IC50 values ranging from 13 to 30 μM, impedes the phosphorylation of ERK1/2, as demonstrated in studies [1] [2].
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    ERK1/2 inhibitor 9
    T781902169302-75-2
    ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates the reduction of phospho-ERK1/2 levels. When conjugated with trans-cyclo-octene (TCO) and Tz-Thalidomide (tetrazine-tagged Thalidomide), it forms the corresponding ERK-CLIPTAC, promoting targeted ERK1/2 degradation [1].
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    ERK1/2 inhibitor 3
    T743732737294-99-2
    ERK1/2 Inhibitor 3, a potent inhibitor of ERK1/2, plays a crucial role in the signal transduction pathway by targeting the Mitogen-activated protein kinase (MAPK) family, specifically the extracellular signal-regulated kinase (ERK). Given its significant impact, this compound holds promise for research or prevention efforts related to cancer, inflammation, or other proliferative diseases[1].
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    ERK-IN-6
    T74997
    ERK-IN-6 (compound 6g) serves as a potent anti-proliferative agent against esophageal squamous cell carcinoma (ESCC), inducing apoptosis through the ERK pathway. This compound has potential applications in ESCC research [1].
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    ERK1/2 inhibitor 6
    T641472634816-13-8
    ERK1/2 inhibitor 6 is a potent inhibitor of ERK1/2. ERK1/2 inhibitor 6 has shown potential for the study or prevention of cancer, inflammation or other proliferative diseases.
    • $1,520
    10-14 weeks
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    ERK1/2 inhibitor 5
    T641552560552-75-0
    ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2. ERK1/2 inhibitor 5 has the potential to investigate or prevent cancer, inflammation or other proliferative diseases.
    • $1,520
    8-10 weeks
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    ERK5-IN-3
    T632681888305-85-8
    ERK5-IN-3 is a selective and potent inhibitor of ERK5 (extracellular signal-associated kinase 5) (IC50: 6 nM). ERK5-IN-3 exhibits anti-proliferative effects on Hela cells (IC50: 31 nM).
    • $1,520
    6-8 weeks
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    ERK5-IN-4
    T616281888305-17-6
    ERK5-IN-4 (compound 34b) is a powerful and specific inhibitor of extracellular signal-related kinase 5 (ERK5) activity. It effectively inhibits both the full-length ERK5 and the truncated ERK5 (ERK5 ΔTAD) kinase activity in HEK293 cells with IC50 values of 77 nM and 300 nM, respectively [1].
    • $1,520
    6-8 weeks
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    p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb #4695R
    T64587
    p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb #4695R is a useful organic compound for research related to life sciences and the catalog number is T64587.
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      Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R
      T64608
      Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R is a useful organic compound for research related to life sciences and the catalog number is T64608.
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        L-161982
        T15681147776-06-5In house
        L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice.
        • $72
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        TargetMol | Inhibitor Hot
        MRTX1133
        T93032621928-55-8In house
        MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.
        • $197
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        TargetMol | Inhibitor Hot
        SCH772984
        T6066942183-80-4
        SCH 772984 is a potent inhibitor of ERK1/ERK2 (IC50: 4/1 nM) and has only weak inhibitory for other 300 tested kinases.
        • $48
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        TargetMol | Inhibitor Hot
        TargetMol | Citations Cited
        Butein
        T6427487-52-5
        Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.
        • $36
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        TargetMol | Citations Cited
        DCLK1-IN-1
        T84182222635-15-4
        DCLK1-IN-1 is a selective and in vivo-compatible chemical probe of the DCLK1 kinase domain .
        • $107
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        TargetMol | Inhibitor Hot
        Hypericin
        T6S0923548-04-9
        1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL-mediated osteoclastogenesis via affecting ERK signalling in vitro and suppresses wear particle-induced osteolysis in vivo.
        • $52
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        TargetMol | Inhibitor Hot
        Allicin
        T3123539-86-6
        Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth muscle cells' proliferation and migration induced by insulin, which may be related to the inhibition of the activation of ERK signal path. Allicin is beneficial in reducing blood cholesterol, triglycerides levels and systolic blood pressure in hypercholesterolemic rats, it may beneficially affect two risk factors for atherosclerosis-hyperlipidemia and hypertension.
        • $40
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        magnolin
        T385731008-18-1
        Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.
        • $93
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        Astragaloside IV
        T297384687-43-4
        Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.
        • $32
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        TargetMol | Citations Cited
        Farrerol
        T6S052524211-30-1
        1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection and could be useful in protection against bovine mastitis. 3. Farrerol inactivates KEAP-1 or act
        • $110
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        ZINC12409120
        T611221010888-06-8In house
        ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23:α-Klotho interaction.
        • $350
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        Gardenin A
        TN411421187-73-5
        Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
        • $197
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        Motixafortide TFA(664334-36-5,Free)
        T14665L
        Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) is an antagonist of CXCR4 with IC50 of ~1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.
        • $117
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        Mefloquine
        T0860L53230-10-7
        Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus, and cancer research.
        • $148
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        FSLLRY-NH2 TFA(245329-02-6 free base)
        TP1904L
        FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
        • $98
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        Epieriocalyxin A
        TN3967191545-24-1
        Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
        • $216
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        JIP-1 (153-163) acetate(438567-88-5 free base)
        TP1897L1
        JIP-1 (153-163) acetate(438567-88-5 free base) is a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). JIP-1 (153-163) acetate(438567-88-5 free base) binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK.
        • $293
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        MMPP
        T280771895957-18-2In house
        MMPP is a novel VEGFR2 inhibitor with anti-inflammatory and potential anticancer activity, inhibits STAT3, inhibits angiogenesis via VEGFR2/AKT/ERK/NF-kappaB pathway, and can be used to alleviate myocardial injury.
        • $257
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        Giripladib
        T31929865200-20-0In house
        Giripladib (PLA695)(PLX-695) is a cPLA2-specific inhibitor that inhibits the radiation-induced increase of phosphorylated ERK and phosphorylated Akt in endothelial cells.
        • $195
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        G36
        T227941392487-51-2In house
        G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 nM, respectively). G36 has no detectable binding activity to either ERα or ERβ. G36 blocks the activation of PI3K or calcium mobilization triggered by estrogen through GPER and it suppresses ERK activation by estrogen or G-1 but not by EGF. G-36 can be used in combination with GPER-selective agonists, like G-1, to distinguish the roles of GPER from those of ERα and ERβ in complex biological systems.
        • $34
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        EF24
        T27242342808-40-6In house
        EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral squamous cell carcinoma (OSCC) via deactivation of the MAPK/ERK signaling pathway.
        • $33
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        PAF (C16)
        T2154774389-68-7In house
        PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled receptor (PAFR). PAF (C16) has shown anti-apoptotic and anti-inflammatory activity in vitro, inhibiting Caspase-dependent apoptosis by interacting with its receptor (PAF-R) to perform cell signaling.
        • Inquiry Price
        6-8 weeks
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        XRP44X
        T20759729605-21-4In house
        XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
        • $50
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