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Results for "

5ht

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    9579
    TargetMol | Inhibitors_Agonists
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    TargetMol | Inhibitors_Agonists
BHQ-O-5HT
BHQO5HT
T304391417436-52-2
BHQ-O-5HT is a serotonin form that is photoactivatable.
    8-10 weeks
    Inquiry
    5HT6-ligand-1
    T100531038988-11-2In house
    5HT6-ligand-1 is an orally active ligand of 5-HT6 receptor (Ki = 1.43 nM).
    • Inquiry Price
    6-8 weeks
    Size
    QTY
    TargetMol | Inhibitor Sale
    Clozapine N-Oxide
    T449434233-69-7
    Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.
    • Inquiry Price
    Size
    QTY
    TargetMol | Inhibitor Hot
    donitriptan hydrochloride
    Donitriptan monohydrochloride, Donitriptan HCl
    T21666170911-68-9In house
    Donitriptan hydrochloride (Donitriptan monohydrochloride) is a potent, high efficacy agonist of 5-HT1B 1D receptors with pKis of 9.4 and 9.3, respectively
    • Inquiry Price
    Size
    QTY
    TargetMol | Inhibitor Sale
    Lecozotan HCl
    SRA-333, SRA333, SRA 333, Lecozotan hydrochloride
    T27806433282-68-9In house
    Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. Chronic administration of Lecozotan HCl did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model demonstrating 5-HT(1A) receptor function.
    • Inquiry Price
    6-8weeks
    Size
    QTY
    SLV-310
    SLV310, SLV 310
    T28809264869-71-8In house
    SLV-310 is a potent dopamine D2 receptor antagonist and 5-HT reuptake receptor inhibitor used in the study of neurological disorders such as bipolar disorder and schizophrenia.
    • Inquiry Price
    6-8 weeks
    Size
    QTY
    Diclofensine
    Ro 8-4650
    T734167165-56-4In house
    Diclofensine (Ro 8-4650) is a monoamine reuptake inhibitor that blocks dopamine (IC50=0.74 nM), norepinephrine (IC50=2.3 nM), and 5-hydroxytryptophan (IC50=3.7 nM) in synaptosomes of the rat brain. dAURK-4 hydrochloride is an inhibitor of dopamine (IC50=0.74 nM), norepinephrine (IC50=2.3 nM) and 5-hydroxytryptophan (IC50=3.7 nM).
    • Inquiry Price
    4-6 weeks
    Size
    QTY
    Haloperidol
    Serenace, Haldol, Aloperidin
    T002552-86-8
    Haloperidol (Serenace) is a highly potent neuroleptic by relieving nervous through the depression of nerve function. In addition, haloperidol has shown about 50-fold efficacy than chlorpromazine, another antipsychotic drug. Haloperidol has some potencies in the treatment of delusions and hallucinations. Its effects are primarily attained through blocking dopamine receptors in the mesocortex and limbic system.
    • Inquiry Price
    Size
    QTY
    Paliperidone
    9-hydroxyrisperidone
    T0076144598-75-4
    Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone.
    • Inquiry Price
    Size
    QTY
    Urapidil hydrochloride
    Urapidil HCl
    T008864887-14-5
    Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist.
    • Inquiry Price
    Size
    QTY
    TargetMol | Inhibitor Sale
    Mirtazapine
    Org3770, 6-Azamianserin
    T013785650-52-8
    Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
    • Inquiry Price
    Size
    QTY
    Sumatriptan succinate
    GR 43175
    T0203103628-48-4
    Sumatriptan succinate (GR 43175), a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache.
    • Inquiry Price
    Size
    QTY
    Amitriptyline hydrochloride
    Tryptizol, Domical, Annoyltin, Amitriptyline HCl
    T0678549-18-8
    Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
    • Inquiry Price
    Size
    QTY
    Atomoxetine hydrochloride
    Tomoxetine hydrochloride, LY 139603 HCl, Atomoxetine HCl, (R)-Tomoxetine hydrochloride
    T086982248-59-7
    Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels.
    • Inquiry Price
    Size
    QTY
    Trimipramine maleate
    Surmontil maleate
    T1045521-78-8
    Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Maleate is the maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine class, with an antidepressant property.
    • Inquiry Price
    Size
    QTY
    Zolmitriptan
    BW-311C90, 311C90
    T1092139264-17-8
    Zolmitriptan (311C90) selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brainstem sensory nuclei. Zolmitriptan is a member of the triptan class of agents with anti-migraine properties. Receptor binding results in constriction of cranial vessels, reduction of vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relieve migraine headaches by inhibition of pro-inflammatory neuropeptide release.
    • Inquiry Price
    Size
    QTY
    Palonosetron hydrochloride
    RS-25259-197, RS 25259, Palonosetron HCl
    T1156135729-62-3
    Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
    • Inquiry Price
    Size
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    Agomelatine
    Valdoxan, Thymanax, S-20098
    T1445138112-76-2
    Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
    • Inquiry Price
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    Olanzapine
    LY170053
    T1567132539-06-1
    Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
    • Inquiry Price
    Size
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    Dopamine hydrochloride
    Dopamine HCl, ASL279
    T164462-31-7
    Dopamine hydrochloride (ASL279), a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine, binds to alpha-1- and beta-1- adrenergic receptors.
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    5-Methyltryptamine hydrochloride
    α-helical CRF 9-41 acetate(90880-23-2 Free base), 2-(5-Methyl-1H-indol-3-yl)ethanamine hydrochloride
    T198131010-95-3
    5-Methyltryptamine hydrochloride is a high-affinity 5-HT1C receptor ligand and a partial agonist of 5-HT. 5-Methyltryptamine hydrochloride protects mice subjected to burn, tourniquet and endotoxin shock.
    • Inquiry Price
    4-6 weeks
    Size
    QTY
    Serotonin hydrochloride
    Serotonin HCl, 5-Hydroxytryptamine hydrochloride, 5-HT hydrochloride, 5-HT HCl
    T2209153-98-0
    Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM).
    • Inquiry Price
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    pCPA methyl ester hydrochloride
    4-Chloro-DL-phenylalanine methyl ester hydrochloride
    T4114314173-40-1
    pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the blood-brain barrier and reduces 5-HT central availability.
    • Inquiry Price
    Size
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    4-Chloro-L-phenylalanine
    L-PCPA, L-4-Chlorophenylalanine
    T7822814173-39-8
    4-Chloro-L-phenylalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis and a non-specific antagonist of tryptophan hydroxylase (TPH1 and TPH2).
    • Inquiry Price
    8-10 weeks
    Size
    QTY