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Autophagy Autophagy

Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.
Cat No. product name
T0026 Sulfalen Sulfalene, a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.
T0087 Sulfacetamide sodium salt hydrate Sulfacetamide sodium monohydrate is a sulfonamide antibiotic. It has been investigated for the treatment of rosacea and pityriasis versicolor.
T0087L Sulfacetamide sodium Sulfacetamide Sodium is an anti-infective agent. It is used topically to treat orally for urinary tract infections and skin infections.
T0123 Sulfanilamide Sulfanilamide can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
T0194 Chloroquine diphosphateHOT Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
T0251 GemcitabineHOT Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
T0415 Guanidine hydrochloride Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
T0510 Sulfaguanidine Sulfaguanidine, a sulfonamide, is served as an anti-infective agent.
T0607 Dihydroartemisinin Dihydroartemisinin is a metabolite of artemisinin.
T0618 Indole-3-Glyoxylyl Chloride Indole-3-Glyoxylyl Chloride is an organic compund with molecular fomula C10H6ClNO2.
T0722 Ursolic acid Ursolic acid(Bungeolic acid), a natural pentacyclic triterpenoid carboxylic acid, shows anti-tumor effects.
T0747 Sulfathiazole Sulfathiazole, an organosulfur compound, has been served as a short-acting sulfa medicine.
T0749 Succinylsulfathiazole Succinylsulfathiazole is a sulfonamide. An ultra long-acting drug.
T0750 Sulfisoxazole Sulfisoxazole is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits...
T0754 Sulfamethizole Sulfamethizole is a sulfathiazole antibacterial reagent.
T0757 Omeprazole Omeprazole is a proton pump inhibitor (PPI), Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
T0767 Sulfapyridine Sulfapyridine is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine.
T0828 Bromhexine hydrochloride Bromhexine hydrochloride is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
T0836 Sulfadoxine Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties.
T0885 Sulfamethoxazole Sulfamethoxazole is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification ...
T0913 Sulfamerazine Sulfamerazine is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para...
T0930 Sulfadiazine Sulfadiazine is a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing wi...
T0956 Abamectin Avermectin B1 (Abamectin) is served as anthelmintic and insecticide.
T0982 (+)-Emetine dihydrochloride hydrate Emetine is a drug used as both an anti-protozoal and to induce vomiting. It is produced from the ipecac root.
T0987 Gimeracil Gimeracil is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.
T10247 Adenosine 5'-diphosphoribose sodium Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a NAD+ metabolite. It is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channe...
T1035 Hesperidin Hesperidin is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowering activ...
T10607 BRD5631 BRD5631 is an autophagy enhancer through an mTOR-independent pathway. It affects several cellular disease phenotypes linked to autophagy, including cell surviva...
T11142 EACC EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. EACC is a reversible autophag...
T11372 GC7 Sulfate GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
T12352L Oxidopamine hydrobromide Oxidopamine hydrobromide is a neurotransmitter dopamine antagonist.
T1248 Sulfanitran Sulfanitran is a sulfonamide antibiotic used in the poultry industry.
T12831L SAR405
T14149 AICAR phosphate AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proin...
T14552 Dactolisib Tosylate Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively). Dactolis...
T15024 Silmitasertib sodium salt Silmitasertib sodium salt is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
T1537 RapamycinHOT Rapamycin, a macrolide compound obtained from Streptomyces hygroscopicus, is a potent and specific mTOR inhibitor (IC50: 0.1 nM in HEK293 cells).
T15412 GPP78 GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y...
T1554 Iohexol Iohexol is an X-ray contrast medium containing iohexol in various concentrations, from 140 to 350 milligrams of iodine per milliliter.
T1660 Silibinin Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of s...
T1662 5-Aminolevulinic acid hydrochloride Aminolevulinic acid hydrochloride is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.
T1666 Fludrocortisone acetate Fludrocortisone, a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of...
T16777 ROC-325 ROC-325 is a novel autophagy inhibitor.
T16791 Rottlerin Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η...
T1879 3-MethyladenineHOT 3-Methyladenine (3-MA) is a selective PI3KV inhibitor, and the IC50s against ps34 and PI3Kγ were 25/60 μM in HeLa cells, respectively.
T19188 ALLO-1 ALLO-1 is an autophagy receptor and is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 throu...
T20879 Tacrolimus hydrate Tacrolimus hydrate is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tac...
T20879 Tacrolimus hydrate Tacrolimus hydrate is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tac...
T2128 SBI0206965 SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.
T2187 2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide is a molecule containing the sulfonamide functional group attached to an aniline.
T2188 Thonzonium Bromide Thonzonium bromide is a cationic surface-active compound.
T2731 Usnic Acid Usnic acid is an antimicrobial, antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induce...
T2754 Oxymatrine Oxymatrine is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis...
T2822 Ginsenoside Rb1 Ginsenoside Rb1 is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
T2888 Pterostilbene Pterostilbene is extracted from Pterocarpus indicus.
T2941 Glucosamine hydrochloride Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
T2950 Schisandrin Schisandrin is a compound with anti-asthmatic, anti-cancer, and anti-inflammatory effects.
T2950 Schisandrin Schisandrin is a compound with anti-asthmatic, anti-cancer, and anti-inflammatory effects.
T2957 Arctigenin (-)-Arctigenin is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD). A...
T2988 (-)-Epigallocatechin Gallate Epigallocatechol Gallate(EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF rece...
T2997 Rheic Acid Rhein is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.
T2S2382 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 µM for...
T3054 Daurisoline Daurisoline is a hERG inhibitor and also an autophagy blocker.
T3155 SMER28 SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and ...
T3362 Eupatilin Eupatilin, a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.
T3436 LYS01 LYS01 free base is a new lysosomal autophagy inhibitor.
T3685 SR9009 SR9009, a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009...
T3688 SR9011 SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).
T3735 Tetrahydro Curcumin Tetrahydrocurcumin, a major metabolite of curcumin, has strong antioxidant and cardioprotective properties.
T3952 TPEN TPEN is a specific cell-permeable heavy metal chelator.
T4123 LYN1604 LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
T4187 Gemcitabine monophosphate sodium salt hydrate Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
T4219 Autophinib Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapam...
T4414 PRIMA-1Met PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredo...
T4519 Alisol A Alisol A may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cell...
T4977 Sofalcone Sofalcone, a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
T5045 GSK4112 GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
T5080 Spermidine hydrochloride Spermidine, a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
T5143 Corynoxine hydrochloride(6877-32-3(free base)) Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
T5162 MRT67307 HCl (1190378-57-4(free base)) MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
T5181 CA-5f CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
T5211 NSC185058 NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
T5211 NSC185058 NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
T5356 MRT68921 HCl MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM, respectively).
T5403 ULK-101 ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.
T5515 Hemin Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.
T5538 DC661 DC661 is palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity
T5793 Britannin Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
T5840 Hoechst 33342 Hoechst 33342, is a Benzimidazole fluorescent dye and a Cell permeable fluorescent DNA stain; binds minor groove of AT-rich regions. HOE 33342 trihydrochlorde...
T5S0658 Corynoxine Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
T5S1097 Neferine 1. Neferine has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be hel...
T5S1287 Ligustilide Ligustilide is an effective constituent extracted from Angelica sinensis.
T5S1467 Cucurbitacin E Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cu...
T5S2102 Leonurine Leonurine is an alkaloid that has been found in H. leonuri and with anti-oxidative and anti-inflammatory.
T6056 Thiamet G Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37, 000-fold selectivity over human lysosomal –hexosaminidase.
T6473 Dioscin Dioscin is a saponin with antitumor activities.
T6740 Bafilomycin A1 Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuol...
T6799 IITZ-01 IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)
T6858 Hydroxyprogesterone caproate Hydroxyprogesterone Caproate is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibi...
T6899 MRT68921 MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.
T6S1315 Oroxylin A 1. Oroxylin A has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting t...
T6S1917 Gomisin A 1. Gomisin A may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPK...
T7174 Urolithin A Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
T7311 Oxyphenisatin acetate Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.
T7370 Talarozole Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.4...
T7530 PD146176 PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive...
T8081 LC3-mHTT-IN-AN1 LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B.   LC3-mHTT-IN-AN1 targeted mHTT to autophag...
T8166 Pennogenin 3-O-beta-chacotrioside Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla with anti-colorectal cancer activity. It modulates autophagy via increas...
T8200 Ginkgolide K Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.
T8308 NL-1 NL-1 is a mitoNEET inhibitor with antileukemic effect.
T8322 BL-918 BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.
T8526 Metformin Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorpti...
T8689 CHLOROQUINE Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria an...
T8808L LYN-1604 2HCl 2216753-86-3(HCl) LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
T8850 sbp-7455 SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
T8853 ULK-101 ULK-101 suppresses autophagy induction and autophagic flux in response to different stimuli.
T8946 Indophagolin Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 an...
T9013 Autogramin-2 Autogramin-2 potently inhibits autophagy induced by either starvation with IC50 of 0.27 μM, and inhibits mTORC1 (Rapamycin; IC50:0.14 μM)
T9062 CA77.1 CA77.1(CA) is a novel chaperon-mediated autophagy (CMA) activator for the treatment of Alzheimer's disease (AD).
T9931 meplazumab meplazumab is a humanized anti-CD147 antibody, as add-on therapy in patients with COVID-19 pneumonia.
TMA1012 Ganoderiol F Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency vir...
TMA1570 Sappanone A Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2...
TN1087 Deoxypodophyllotoxin Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
TN1563 Dehydropachymic acid Dehydropachymic acid shows antiinflammatory activity.
TN1702 Glycycoumarin Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
TN2118 Pulsatilla saponin D Pulsatilla saponin D exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activity of...
TN2244 Sulfuretin Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its abil...
TN2646 16-Hydroxycleroda-3,13-dien-15,16-olide 16-Hydroxycleroda-3,13-dien-15,16-olide, and prodigiosin are presented as candidates for autophagy inducers that can trigger cell death in a supplement or alter...
TN3057 4-O-Methylbutein 4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) may have anti-inflammation activity, it is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of...
TN3144 6,4'-Dihydroxy-7-methoxyflavanone 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and functio...
TN3609 Catalposide Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and H...
TN3694 Coniferaldehyde Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 de...
TN3726 Cudraflavone B Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and m...
TN3806 Dehydroglyasperin C Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
TN3910 Ecdysone Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D ...
TN4038 Eupatolide Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
TN4064 Flavoglaucin Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or canna...
TN4213 Hirsutenone Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid per...
TN4234 Hydrangenol Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PC...
TN4420 Latifolin Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
TN4661 Nodosin Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 express...
TN4774 Physalin A Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate can...
TN4778 Physalin H Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR indu...
TN6705 Graveoline Graveoline is an apoptosis and autophagy inducer in skin melanoma cancer cells
TN6705 Graveoline Graveoline is an apoptosis and autophagy inducer in skin melanoma cancer cells
TQ0003 740 Y-P 740 Y-P is a potent and cell-permeable activator of PI3K.
TQ0081 JPH203 JPH203 is an effective and specific L-type amino acid transporter 1 (LAT-1) inhibitor.
TQ0258 Corynoxine B Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese).
TQ0309 Glaucocalyxin B Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM)...
Sulfalen
T0026CAS 152-47-6
Sulfalene, a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.
Sulfacetamide sodium salt hydrate
T0087CAS 6209-17-2
Sulfacetamide sodium monohydrate is a sulfonamide antibiotic. It has been investigated for the treatment of rosacea and pityriasis versicolor.
Sulfacetamide sodium
T0087LCAS 127-56-0
Sulfacetamide Sodium is an anti-infective agent. It is used topically to treat orally for urinary tract infections and skin infections.
Sulfanilamide
T0123CAS 63-74-1
Sulfanilamide can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
Chloroquine diphosphate HOT
T0194CAS 50-63-5
Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
Gemcitabine HOT
T0251CAS 95058-81-4
Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
Guanidine hydrochloride
T0415CAS 50-01-1
Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
Sulfaguanidine
T0510CAS 57-67-0
Sulfaguanidine, a sulfonamide, is served as an anti-infective agent.
Dihydroartemisinin
T0607CAS 71939-50-9
Dihydroartemisinin is a metabolite of artemisinin.
Indole-3-Glyoxylyl Chloride
T0618CAS 22980-09-2
Indole-3-Glyoxylyl Chloride is an organic compund with molecular fomula C10H6ClNO2.
Ursolic acid
T0722CAS 77-52-1
Ursolic acid(Bungeolic acid), a natural pentacyclic triterpenoid carboxylic acid, shows anti-tumor effects.
Sulfathiazole
T0747CAS 72-14-0
Sulfathiazole, an organosulfur compound, has been served as a short-acting sulfa medicine.
Succinylsulfathiazole
T0749CAS 116-43-8
Succinylsulfathiazole is a sulfonamide. An ultra long-acting drug.
Sulfisoxazole
T0750CAS 127-69-5
Sulfisoxazole is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits...
Sulfamethizole
T0754CAS 144-82-1
Sulfamethizole is a sulfathiazole antibacterial reagent.
Omeprazole
T0757CAS 73590-58-6
Omeprazole is a proton pump inhibitor (PPI), Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
Sulfapyridine
T0767CAS 144-83-2
Sulfapyridine is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine.
Bromhexine hydrochloride
T0828CAS 611-75-6
Bromhexine hydrochloride is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
Sulfadoxine
T0836CAS 2447-57-6
Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties.
Sulfamethoxazole
T0885CAS 723-46-6
Sulfamethoxazole is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification ...
Sulfamerazine
T0913CAS 127-79-7
Sulfamerazine is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para...
Sulfadiazine
T0930CAS 68-35-9
Sulfadiazine is a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing wi...
Abamectin
T0956CAS 71751-41-2
Avermectin B1 (Abamectin) is served as anthelmintic and insecticide.
(+)-Emetine dihydrochloride hydrate
T0982CAS 7083-71-8
Emetine is a drug used as both an anti-protozoal and to induce vomiting. It is produced from the ipecac root.
Gimeracil
T0987CAS 103766-25-2
Gimeracil is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.
Adenosine 5'-diphosphoribose sodium
T10247CAS 68414-18-6
Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a NAD+ metabolite. It is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channe...
Hesperidin
T1035CAS 520-26-3
Hesperidin is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowering activ...
BRD5631
T10607CAS T10607
BRD5631 is an autophagy enhancer through an mTOR-independent pathway. It affects several cellular disease phenotypes linked to autophagy, including cell surviva...
EACC
T11142CAS 864941-31-1
EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. EACC is a reversible autophag...
GC7 Sulfate
T11372CAS 150417-90-6
GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
Oxidopamine hydrobromide
T12352LCAS 636-00-0
Oxidopamine hydrobromide is a neurotransmitter dopamine antagonist.
Sulfanitran
T1248CAS 122-16-7
Sulfanitran is a sulfonamide antibiotic used in the poultry industry.
SAR405
T12831LCAS 1523406-39-4
AICAR phosphate
T14149CAS 681006-28-0
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proin...
Dactolisib Tosylate
T14552CAS 1028385-32-1
Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively). Dactolis...
Silmitasertib sodium salt
T15024CAS 1309357-15-0
Silmitasertib sodium salt is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
Rapamycin HOT
T1537CAS 53123-88-9
Rapamycin, a macrolide compound obtained from Streptomyces hygroscopicus, is a potent and specific mTOR inhibitor (IC50: 0.1 nM in HEK293 cells).
GPP78
T15412CAS 1202580-59-3
GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y...
Iohexol
T1554CAS 66108-95-0
Iohexol is an X-ray contrast medium containing iohexol in various concentrations, from 140 to 350 milligrams of iodine per milliliter.
Silibinin
T1660CAS 22888-70-6
Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of s...
5-Aminolevulinic acid hydrochloride
T1662CAS 5451-09-2
Aminolevulinic acid hydrochloride is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.
Fludrocortisone acetate
T1666CAS 514-36-3
Fludrocortisone, a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of...
ROC-325
T16777CAS 1859141-26-6
ROC-325 is a novel autophagy inhibitor.
Rottlerin
T16791CAS 82-08-6
Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η...
3-Methyladenine HOT
T1879CAS 5142-23-4
3-Methyladenine (3-MA) is a selective PI3KV inhibitor, and the IC50s against ps34 and PI3Kγ were 25/60 μM in HeLa cells, respectively.
ALLO-1
T19188CAS 37468-32-9
ALLO-1 is an autophagy receptor and is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 throu...
Tacrolimus hydrate
T20879CAS 109581-93-3
Tacrolimus hydrate is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tac...
Tacrolimus hydrate
T20879CAS 109581-93-3
Tacrolimus hydrate is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tac...
SBI0206965
T2128CAS 1884220-36-3
SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.
2-Aminobenzenesulfonamide
T2187CAS 3306-62-5
2-Aminobenzenesulfonamide is a molecule containing the sulfonamide functional group attached to an aniline.
Thonzonium Bromide
T2188CAS 553-08-2
Thonzonium bromide is a cationic surface-active compound.
Usnic Acid
T2731CAS 125-46-2
Usnic acid is an antimicrobial, antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induce...
Oxymatrine
T2754CAS 16837-52-8
Oxymatrine is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis...
Ginsenoside Rb1
T2822CAS 41753-43-9
Ginsenoside Rb1 is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
Pterostilbene
T2888CAS 537-42-8
Pterostilbene is extracted from Pterocarpus indicus.
Glucosamine hydrochloride
T2941CAS 66-84-2
Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
Schisandrin
T2950CAS 7432-28-2
Schisandrin is a compound with anti-asthmatic, anti-cancer, and anti-inflammatory effects.
Schisandrin
T2950CAS 7432-28-2
Schisandrin is a compound with anti-asthmatic, anti-cancer, and anti-inflammatory effects.
Arctigenin
T2957CAS 7770-78-7
(-)-Arctigenin is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD). A...
(-)-Epigallocatechin Gallate
T2988CAS 989-51-5
Epigallocatechol Gallate(EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF rece...
Rheic Acid
T2997CAS 478-43-3
Rhein is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.
3'-Hydroxypterostilbene
T2S2382CAS 475231-21-1
3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 µM for...
Daurisoline
T3054CAS 70553-76-3
Daurisoline is a hERG inhibitor and also an autophagy blocker.
SMER28
T3155CAS 307538-42-7
SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and ...
Eupatilin
T3362CAS 22368-21-4
Eupatilin, a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.
LYS01
T3436CAS 1391426-22-4
LYS01 free base is a new lysosomal autophagy inhibitor.
SR9009
T3685CAS 1379686-30-2
SR9009, a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009...
SR9011
T3688CAS 1379686-29-9
SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).
Tetrahydro Curcumin
T3735CAS 36062-04-1
Tetrahydrocurcumin, a major metabolite of curcumin, has strong antioxidant and cardioprotective properties.
TPEN
T3952CAS 16858-02-9
TPEN is a specific cell-permeable heavy metal chelator.
LYN1604
T4123CAS 2088939-99-3
LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
Gemcitabine monophosphate sodium salt hydrate
T4187CAS 1638288-31-9
Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
Autophinib
T4219CAS 1644443-47-9
Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapam...
PRIMA-1Met
T4414CAS 5291-32-7
PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredo...
Alisol A
T4519CAS 19885-10-0
Alisol A may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cell...
Sofalcone
T4977CAS 64506-49-6
Sofalcone, a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
GSK4112
T5045CAS 1216744-19-2
GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
Spermidine hydrochloride
T5080CAS 334-50-9
Spermidine, a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
Corynoxine hydrochloride(6877-32-3(free base))
T5143CAS T5143
Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
MRT67307 HCl (1190378-57-4(free base))
T5162CAS T5162
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
CA-5f
T5181CAS 1370032-19-1
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
NSC185058
T5211CAS 39122-38-8
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
NSC185058
T5211CAS 39122-38-8
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
MRT68921 HCl
T5356CAS 2070014-87-6
MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM, respectively).
ULK-101
T5403CAS T5403
ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.
Hemin
T5515CAS 16009-13-5
Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.
DC661
T5538CAS 1872387-43-3
DC661 is palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity
Britannin
T5793CAS 33627-28-0
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
Hoechst 33342
T5840CAS 23491-52-3
Hoechst 33342, is a Benzimidazole fluorescent dye and a Cell permeable fluorescent DNA stain; binds minor groove of AT-rich regions. HOE 33342 trihydrochlorde...
Corynoxine
T5S0658CAS 6877-32-3
Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
Neferine
T5S1097CAS 2292-16-2
1. Neferine has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be hel...
Ligustilide
T5S1287CAS 4431-01-0
Ligustilide is an effective constituent extracted from Angelica sinensis.
Cucurbitacin E
T5S1467CAS 18444-66-1
Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cu...
Leonurine
T5S2102CAS 24697-74-3
Leonurine is an alkaloid that has been found in H. leonuri and with anti-oxidative and anti-inflammatory.
Thiamet G
T6056CAS 1009816-48-1
Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37, 000-fold selectivity over human lysosomal –hexosaminidase.
Dioscin
T6473CAS 19057-60-4
Dioscin is a saponin with antitumor activities.
Bafilomycin A1
T6740CAS 88899-55-2
Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuol...
IITZ-01
T6799CAS 1807988-47-1
IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)
Hydroxyprogesterone caproate
T6858CAS 630-56-8
Hydroxyprogesterone Caproate is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibi...
MRT68921
T6899CAS 1190379-70-4
MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.
Oroxylin A
T6S1315CAS 480-11-5
1. Oroxylin A has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting t...
Gomisin A
T6S1917CAS 58546-54-6
1. Gomisin A may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPK...
Urolithin A
T7174CAS 1143-70-0
Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
Oxyphenisatin acetate
T7311CAS 115-33-3
Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.
Talarozole
T7370CAS 201410-53-9
Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.4...
PD146176
T7530CAS 4079-26-9
PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive...
LC3-mHTT-IN-AN1
T8081CAS 486443-73-6
LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B.   LC3-mHTT-IN-AN1 targeted mHTT to autophag...
Pennogenin 3-O-beta-chacotrioside
T8166CAS 55916-52-4
Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla with anti-colorectal cancer activity. It modulates autophagy via increas...
Ginkgolide K
T8200CAS 153355-70-5
Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.
NL-1
T8308CAS 188532-26-5
NL-1 is a mitoNEET inhibitor with antileukemic effect.
BL-918
T8322CAS 2101517-69-3
BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.
Metformin
T8526CAS 657-24-9
Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorpti...
CHLOROQUINE
T8689CAS 54-05-7
Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria an...
LYN-1604 2HCl 2216753-86-3(HCl)
T8808LCAS T8808L
LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
sbp-7455
T8850CAS 1884222-74-5
SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
ULK-101
T8853CAS 2443816-45-1
ULK-101 suppresses autophagy induction and autophagic flux in response to different stimuli.
Indophagolin
T8946CAS 1207660-00-1
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 an...
Autogramin-2
T9013CAS 2375541-45-8
Autogramin-2 potently inhibits autophagy induced by either starvation with IC50 of 0.27 μM, and inhibits mTORC1 (Rapamycin; IC50:0.14 μM)
CA77.1
T9062CAS 2412270-22-3
CA77.1(CA) is a novel chaperon-mediated autophagy (CMA) activator for the treatment of Alzheimer's disease (AD).
meplazumab
T9931CAS T9931
meplazumab is a humanized anti-CD147 antibody, as add-on therapy in patients with COVID-19 pneumonia.
Ganoderiol F
TMA1012CAS 114567-47-4
Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency vir...
Sappanone A
TMA1570CAS 102067-84-5
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2...
Deoxypodophyllotoxin
TN1087CAS 19186-35-7
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
Dehydropachymic acid
TN1563CAS 77012-31-8
Dehydropachymic acid shows antiinflammatory activity.
Glycycoumarin
TN1702CAS 94805-82-0
Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
Pulsatilla saponin D
TN2118CAS 848784-85-0
Pulsatilla saponin D exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activity of...
Sulfuretin
TN2244CAS 120-05-8
Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its abil...
16-Hydroxycleroda-3,13-dien-15,16-olide
TN2646CAS 141979-19-3
16-Hydroxycleroda-3,13-dien-15,16-olide, and prodigiosin are presented as candidates for autophagy inducers that can trigger cell death in a supplement or alter...
4-O-Methylbutein
TN3057CAS 13323-67-6
4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) may have anti-inflammation activity, it is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of...
6,4'-Dihydroxy-7-methoxyflavanone
TN3144CAS 189689-32-5
6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and functio...
Catalposide
TN3609CAS 6736-85-2
Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and H...
Coniferaldehyde
TN3694CAS 20649-42-7
Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 de...
Cudraflavone B
TN3726CAS 19275-49-1
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and m...
Dehydroglyasperin C
TN3806CAS 199331-35-6
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
Ecdysone
TN3910CAS 3604-87-3
Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D ...
Eupatolide
TN4038CAS 6750-25-0
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
Flavoglaucin
TN4064CAS 523-73-9
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or canna...
Hirsutenone
TN4213CAS 41137-87-5
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid per...
Hydrangenol
TN4234CAS 480-47-7
Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PC...
Latifolin
TN4420CAS 10154-42-4
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
Nodosin
TN4661CAS 10391-09-0
Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 express...
Physalin A
TN4774CAS 23027-91-0
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate can...
Physalin H
TN4778CAS 70241-09-7
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR indu...
Graveoline
TN6705CAS 485-61-0
Graveoline is an apoptosis and autophagy inducer in skin melanoma cancer cells
Graveoline
TN6705CAS 485-61-0
Graveoline is an apoptosis and autophagy inducer in skin melanoma cancer cells
740 Y-P
TQ0003CAS 1236188-16-1
740 Y-P is a potent and cell-permeable activator of PI3K.
JPH203
TQ0081CAS 1037592-40-7
JPH203 is an effective and specific L-type amino acid transporter 1 (LAT-1) inhibitor.
Corynoxine B
TQ0258CAS 17391-18-3
Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese).
Glaucocalyxin B
TQ0309CAS 80508-81-2
Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM)...