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Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.
Cat. No. Product name CAS No. Purity Chemical Structure
T6178 PTC-209 hydrobromide 1217022-63-3 98%
PTC-209 HBr is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of ca...
T14149 AICAR phosphate 681006-28-0 98%
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proinf...
T14552 Dactolisib Tosylate 1028385-32-1 98%
Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively). Dactolisib To...
T0242L Sitagliptin phosphate monohydrate 654671-77-9 98%
Sitagliptin phosphate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.
T4123 LYN-1604 2088939-99-3 98%
LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
TN4420 Latifolin 10154-42-4 98%
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
TN2118 Lup-20(29)-en-28-oic acid 848784-85-0 98%
Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activit...
TMA1012 Ganoderiol F 114567-47-4 98%
Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency viru...
TN4774 Physalin A 23027-91-0 98%
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T11372 GC7 Sulfate 150417-90-6 98%
GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
T7162 R1487 Hydrochloride 449808-64-4 98%
R1487 (Hydrochloride) is an orally bioavailable and highly selective inhibitors of p38α.
TQ0215 Salinomycin sodium salt 55721-31-8 98%
Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
TN4778 Physalin H 70241-09-7 98%
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induc...
T32039 HADA Hydrochloride 2253733-10-5 98%
HADA Hydrochloride is a blue (λem~450 nm) fluorescent D-amino acid (FDAA). FDAAs are efficiently incorporated into the peptidoglycans (PGs) of diverse bacterial ...
T19188 ALLO-1 37468-32-9 98%
ALLO-1 is an autophagy receptor and is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 throug...
T1606 Fasudil 103745-39-7 98%
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
TN4213 Hirsutenone 41137-87-5 98%
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
TN3057 4-O-Methylbutein 13323-67-6 98%
4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) may have anti-inflammation activity, it is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of ...
T15412 GPP78 1202580-59-3 98%
GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y ...
T10607 BRD5631 2446154-91-0 98%
BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked t...
PTC-209 hydrobromide
T6178
PTC-209 HBr is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of ca...
AICAR phosphate
T14149
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proinf...
Dactolisib Tosylate
T14552
Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively). Dactolisib To...
Sitagliptin phosphate monohydrate
T0242L
Sitagliptin phosphate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.
LYN-1604
T4123
LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
Latifolin
TN4420
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
Lup-20(29)-en-28-oic acid
TN2118
Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activit...
Ganoderiol F
TMA1012
Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency viru...
Physalin A
TN4774
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
GC7 Sulfate
T11372
GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
R1487 Hydrochloride
T7162
R1487 (Hydrochloride) is an orally bioavailable and highly selective inhibitors of p38α.
Salinomycin sodium salt
TQ0215
Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
Physalin H
TN4778
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induc...
HADA Hydrochloride
T32039
HADA Hydrochloride is a blue (λem~450 nm) fluorescent D-amino acid (FDAA). FDAAs are efficiently incorporated into the peptidoglycans (PGs) of diverse bacterial ...
ALLO-1
T19188
ALLO-1 is an autophagy receptor and is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 throug...
Fasudil
T1606
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
Hirsutenone
TN4213
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
4-O-Methylbutein
TN3057
4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) may have anti-inflammation activity, it is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of ...
GPP78
T15412
GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y ...
BRD5631
T10607
BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked t...
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