Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T6178	PTC-209 hydrobromide	1217022-63-3	98%
T6178	PTC-209 HBr is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of ca...
T14149	AICAR phosphate	681006-28-0	98%
T14149	AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proinf...
T14552	Dactolisib Tosylate	1028385-32-1	98%
T14552	Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively). Dactolisib To...
T0242L	Sitagliptin phosphate monohydrate	654671-77-9	98%
T0242L	Sitagliptin phosphate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.
T4123	LYN-1604	2088939-99-3	98%
T4123	LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
TN4420	Latifolin	10154-42-4	98%
TN4420	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
TN2118	Lup-20(29)-en-28-oic acid	848784-85-0	98%
TN2118	Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activit...
TMA1012	Ganoderiol F	114567-47-4	98%
TMA1012	Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency viru...
TN4774	Physalin A	23027-91-0	98%
TN4774	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T11372	GC7 Sulfate	150417-90-6	98%
T11372	GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
T7162	R1487 Hydrochloride	449808-64-4	98%
T7162	R1487 (Hydrochloride) is an orally bioavailable and highly selective inhibitors of p38α.
TQ0215	Salinomycin sodium salt	55721-31-8	98%
TQ0215	Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
TN4778	Physalin H	70241-09-7	98%
TN4778	Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induc...
T32039	HADA Hydrochloride	2253733-10-5	98%
T32039	HADA Hydrochloride is a blue (λem~450 nm) fluorescent D-amino acid (FDAA). FDAAs are efficiently incorporated into the peptidoglycans (PGs) of diverse bacterial ...
T19188	ALLO-1	37468-32-9	98%
T19188	ALLO-1 is an autophagy receptor and is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 throug...
T1606	Fasudil	103745-39-7	98%
T1606	Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
TN4213	Hirsutenone	41137-87-5	98%
TN4213	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
TN3057	4-O-Methylbutein	13323-67-6	98%
TN3057	4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) may have anti-inflammation activity, it is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of ...
T15412	GPP78	1202580-59-3	98%
T15412	GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y ...
T10607	BRD5631	2446154-91-0	98%
T10607	BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked t...