egf-r

EGF-R (661-681) T669 Peptide, a substrate of MAPK, facilitates the measurement of MAPK catalytic activity [1].

Oligopeptide-41, a bioactive peptide, is recognized for its hair growth-promoting properties and is reported as an ingredient in cosmetics [1].

OK2, a specific inhibitor of the CCN2 EGFR interaction, effectively disrupts this interaction by binding to the CT domain of CCN2 and holds potential for research on kidney fibrosis and chronic kidney disease [1].

Cyclic(YCDGFYACYMDV) is a HER2 signaling pathway inhibitor with anticancer properties. In aqueous solution, Cyclic(YCDGFYACYMDV) self-assembles into nanoparticles that target HER2 on cancer cells, converting into nanofibrils. This process disrupts HER2 dimerization and subsequent downstream signaling, leading to apoptosis (Apoptosis) of cancer cells. Its inhibitory effect on HER2-positive breast cancer has been demonstrated as effective in mouse xenograft models.

HER2-targeted peptide H6F is a molecule designed to bind to HER2 and target breast cancer cells, characterized by the amino acid sequence YLFFVFER. It can conjugate with the bifunctional chelator hydrazinonicotinamide (HYNIC) for binding with 99mTc for radiolabeling purposes. Single-photon emission computed tomography (SPECT) imaging demonstrates that the radiolabeled HER2-targeted peptide H6F specifically accumulates in HER2-positive MDA-MB-453 tumor-bearing mouse models. This peptide is useful for studies in tumor molecular imaging.