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Rilematovir

Name: Rilematovir
Brand: TargetMol
SKU: T15621
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15621Cas No. 1383450-81-4

Alias JNJ-678, JNJ-53718678

Rilematovir (JNJ-678) is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncytial virus treatment.

Rilematovir

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Purity: 99.82%

Catalog No. T15621Alias JNJ-678, JNJ-53718678Cas No. 1383450-81-4

Rilematovir (JNJ-678) is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncytial virus treatment.

Pack Size	Price	Availability
5 mg	$40	In Stock
10 mg	$68	In Stock
25 mg	$133	In Stock
50 mg	$197	In Stock
100 mg	$292	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock

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Batch Information

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Purity:99.82%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Rilematovir (JNJ-678) is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncytial virus treatment.
In vitro	Rilematovir is highly active against a number of RSV strains from both A and B subtypes, especially the A2 strain. The EC50 of HeLa cells is 460 pM[1].
In vivo	Rilematovir efficiently suppresses established acute lower respiratory tract infection in the animals after oral treatment of neonatal lambs with Rilematovir, or with an equally active close analog[1].
Synonyms	JNJ-678, JNJ-53718678

Chemical Properties

Molecular Weight	500.92
Formula	C₂₁H₂₀ClF₃N₄O₃S
Cas No.	1383450-81-4
Smiles	CS(=O)(=O)CCCn1c(Cn2c3cnccc3n(CC(F)(F)F)c2=O)cc2cc(Cl)ccc12
Relative Density.	1.50 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 58.5 mg/mL (116.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9963 mL	9.9816 mL	19.9633 mL	99.8163 mL
5 mM	0.3993 mL	1.9963 mL	3.9927 mL	19.9633 mL
10 mM	0.1996 mL	0.9982 mL	1.9963 mL	9.9816 mL
20 mM	0.0998 mL	0.4991 mL	0.9982 mL	4.9908 mL
50 mM	0.0399 mL	0.1996 mL	0.3993 mL	1.9963 mL
100 mM	0.0200 mL	0.0998 mL	0.1996 mL	0.9982 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc