ppa

PPA serves as an ADC linker (US20060073528A1), facilitating the production of antibody-drug conjugates.

Pyropheophorbide-a (Ppa) shows promise as a photosensitizer in tumor photodynamic therapy (PDT).

PPA-904, a specific phenothiazine photosensitizer, is used in photodynamic therapy (PDT).

PPA-904 FA is a cationic photosensitizer with broad-spectrum antimicrobial activity for use in photodynamic studies (PDT) studies, which can be used to study chronic leg ulcers and diabetic foot ulcers.

PPA-037 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It induces the degradation of Cyclin K, thereby enhancing antiproliferative effects on tumor cells. PPA-037 holds potential for use in cancer research.

PPA-037 TFA is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It promotes the degradation of Cyclin K, thereby enhancing its antiproliferative effects on tumor cells. PPA-037 TFA holds potential for use in cancer research.

2',3'-cGAMP-C2-PPA (45) is a cyclic di-nucleotide that acts as a STING agonist (US20210015941A1). It is a drug-linker conjugate for antibody-drug conjugates (ADC) used in the targeted treatment of cancer.

(D)-PPA 1 TFA, a hydrolysis-resistant D-peptide antagonist, is a potent PD-1/PD-L1 inhibitor with an affinity for PD-1 of 0.51 μM, demonstrating efficacy both in vitro and in vivo [1].

2-PPA serves as a selective TMEM175 inhibitor (IC50 = 32 μM), primarily influencing lysosomal activity. 2-PPA enhances lysosomal macromolecular catabolism through acute TMEM175 inhibition, thereby modulating macrophage activity and lysosomal degradation processes. 2-PPA is used in lysosomal biology and neurodegeneration-related research systems to investigate ion channel regulation, lysosomal function, and macrophage-mediated catabolic activity, particularly in Parkinson’s disease research models.

PPA24 (compound 19a) is an activator of PP2A. It inhibits induced apoptosis and oxidative stress, and also reduces the expression levels of c-Myc. PPA24 is applicable in cancer research studies.

2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE is targets the thyroid stimulating hormone receptor (human)

Human IgG1 kappa, Isotype Control is a humanized IgG-like monoclonal antibody and an isotype control antibody for human IgG1κ.

MTPPA (M 5011) is treating inflammation and pain.

Lappaconitine ((+)-Lappaconitine), isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.

Human IgG4 (S228P) kappa, Isotype Control is a human-mouse chimeric antibody that can be used to study autoimmune diseases.

ADC Control Human IgG1 kappa-vcMMAE is a human monoclonal antibody and an isotype control for Human IgG1 kappa-vcMMAE that inhibits tubulin polymerization.

Human IgG1 (LALAPG) kappa-Deruxtecan, ADC Control is an isotype-matched antibody-drug conjugate (ADC) control prepared by conjugating a human IgG1 kappa monoclonal antibody scaffold with the DNA topoisomerase I inhibitor Deruxtecan (DXd). It is used to distinguish between target-specific ADC activity and nonspecific cytotoxicity.

Human IgG1(L234A/L235A/P329G)-Kappa Isotype control is the isotype control for the Human IgG1 (LALAPG)-Kappa antibody, used to exclude or reduce false-positive results caused by non-specific binding.

PPARα-MO-1 is a potent PPARα modulator. It exhibits valuable biochemical properties, including good solubility in aqueous solutions, stability under physiological conditions, and high binding affinity for the PPARα receptor, making it highly effective for potential therapeutic applications related to lipid metabolism and cardiovascular health. (Patent No. 123456) [MW=456.78]

PPAR agonist 1 is a dual PPAR α/γ agonist used for lowering blood glucose, lipid levels, cholesterol, and body weight.

Pparδ agonist 1 is an agonist of PPAR-δ(EC50 of 5.06 nM).

Pparδ agonist 2 is an agonist of PPARδ.

Apparicine is a useful organic compound for research related to life sciences and the catalog number is T125353.

Glucocapparin is a useful organic compound for research related to life sciences and the catalog number is T125730.