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MK-0533

Name: MK-0533
Brand: TargetMol
SKU: T68000L
Price: 94 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68000LCas No. 668455-28-5

MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.

MK-0533

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Purity: 99.99%

Catalog No. T68000LCas No. 668455-28-5

MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$94	In Stock	In Stock
5 mg	$231	In Stock	In Stock
10 mg	$343	In Stock	In Stock
25 mg	$551	In Stock	In Stock
50 mg	$793	In Stock	In Stock
100 mg	$1,090	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

ee:97.88%

Appearance:Solid

Color:Yellow

Resource Download

COA CSFC HNMR ORP LCMS

Product Introduction

MK-0533 AI Summary

MK-0533 is a potent agonist of human PPARgamma with an EC50 value of 2.0 nM. It also demonstrates agonist activity at human PPARalpha and PPARgamma in various cell lines, as well as in mouse, hamster, and dog PPARalpha. The compound displays high selectivity for PPARgamma over PPARalpha across different species. In db/db mice, it exhibits antihyperglycemic activity and modulates plasma adiponectin levels. Pharmacokinetic studies in rats, dogs, and monkeys reveal favorable bioavailability, clearance, and distribution profiles. Toxicological evaluations highlight potential effects on liver weight and adverse impacts on brown adipose tissue weight in Sprague-Dawley rats..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.

Chemical Properties

Molecular Weight	527.49
Formula	C₂₈H₂₄F₃NO₆
Cas No.	668455-28-5
Smiles	CC=1N(C=2C(C1C(=O)C3=CC=C(OC)C=C3)=CC=C(OC(F)(F)F)C2)C4=CC(O[C@@H](C(O)=O)CC)=CC=C4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (104.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8958 mL	9.4789 mL	18.9577 mL	94.7885 mL
5 mM	0.3792 mL	1.8958 mL	3.7915 mL	18.9577 mL
10 mM	0.1896 mL	0.9479 mL	1.8958 mL	9.4789 mL
20 mM	0.0948 mL	0.4739 mL	0.9479 mL	4.7394 mL
50 mM	0.0379 mL	0.1896 mL	0.3792 mL	1.8958 mL
100 mM	0.0190 mL	0.0948 mL	0.1896 mL	0.9479 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc