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Cevoglitazar

Name: Cevoglitazar
Brand: TargetMol
SKU: T26986
Price: 65 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26986Cas No. 839673-52-8

Alias LBM-642, LBM642, LBM 642

Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.

Cevoglitazar

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Purity: 97%

Catalog No. T26986Alias LBM-642, LBM642, LBM 642Cas No. 839673-52-8

Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$65	In Stock	In Stock
5 mg	$156	In Stock	In Stock
10 mg	$233	In Stock	In Stock
25 mg	$392	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97%

ee:100%

Appearance:Solid

Color:White

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COA CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.
In vivo	Cevoglitazar (0.5 mg/kg; 7 d) plasma levels of glucose and insulin were normalized.[1] Cevoglitazar (50 and 500 mg/kg; obese and insulin-resistant cynomolgus monkeys; 4 weeks) lowered food intake and body weight in a dose-dependent manner. In these animals, cevoglitazar also reduced fasting plasma insulin and, at the highest dose, reduced hemoglobin A1c levels by 0.4%.[1] Cevoglitazar (5 mg/kg) reduced BW gain and adiposity, independent of food intake. In the muscle, cevoglitazar improves the lipid profile via both PPARalpha- and PPARgamma-mediated mechanisms, and cevoglitazar reduced hepatic lipid concentration below baseline levels (p < 0.05). Metabolic profiling showed that in the liver, cevoglitazar functions largely through PPARalpha agonism resulting in increased beta-oxidation. Cevoglitazar only induced small changes to the lipid composition of visceral fat.[2]
Synonyms	LBM-642, LBM642, LBM 642

Chemical Properties

Molecular Weight	558.53
Formula	C₂₇H₂₁F₃N₂O₆S
Cas No.	839673-52-8
Smiles	S(=O)(=O)(N1C=2C(C[C@@H]1C(O)=O)=CC=CC2)C3=CC=C(OCC=4N=C(OC4C)C5=CC=C(C(F)(F)F)C=C5)C=C3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (89.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7904 mL	8.9521 mL	17.9041 mL	89.5207 mL
5 mM	0.3581 mL	1.7904 mL	3.5808 mL	17.9041 mL
10 mM	0.1790 mL	0.8952 mL	1.7904 mL	8.9521 mL
20 mM	0.0895 mL	0.4476 mL	0.8952 mL	4.4760 mL
50 mM	0.0358 mL	0.1790 mL	0.3581 mL	1.7904 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc