Enterovirus

HR-568 displays broad-spectrum anti-enterovirus activity. It inhibits enterovirus strains EV-A71, E30, and CVA24 in MRC-5 cells, with EC50 values of 1.53 μM, 0.4 μM, and 1.22 μM, respectively. HR-568 targets the hydrophobic pocket on enterovirus capsid proteins, thereby hindering viral replication.

CoxB-IN-1 (7a) exhibits antiviral activity against Coxsackie B virus (CoxB). This compound demonstrates dual functionality by inhibiting both virus adsorption and replication. Additionally, CoxB-IN-1 (7a) shows significant potential as an inhibitor of the Coxsackie virus 3C protease.

EV-A71-IN-3 (Compound IRE-03-3) is an inhibitor of the enterovirus A71 (EV-A71). It targets the internal ribosome entry site (IRES) of EV-A71, blocking IRES-mediated translation and thereby preventing viral proliferation, with an EC50 of 11.96 μM.

MDL-860 is a broad-spectrum antiviral compound targeting small RNA viruses and exhibits low cytotoxicity to human cells. MDL-860 is useful for research into viral infections.

Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).