Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

SC83288

Name: SC83288
Brand: TargetMol
SKU: T218663
Rating: 4.5 (1 reviews)

Copy Product Info

🥰Excellent

Synonyms:

Catalog No. T218663 Copy Product Info

🥰Excellent

SC83288 is a Plasmodium falciparum PfDNMT2 inhibitor with an IC50 of 7 μM. It disrupts the epigenetic regulation in Plasmodium falciparum, inhibiting DNA replication and nuclear division, which arrests asexual blood-stage development and induces the formation of condensed forms. It does not affect cytokinesis or parasite egress post-nuclear division. SC83288 is applicable in malaria-related studies.

SC83288

Cas No. 1237645-43-0

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

Product Introduction

Bioactivity

Description	SC83288 is a Plasmodium falciparum PfDNMT2 inhibitor with an IC50 of 7 μM. It disrupts the epigenetic regulation in Plasmodium falciparum, inhibiting DNA replication and nuclear division, which arrests asexual blood-stage development and induces the formation of condensed forms. It does not affect cytokinesis or parasite egress post-nuclear division. SC83288 is applicable in malaria-related studies.
In vitro	SC83288 effectively inhibits the intraerythrocytic growth of wild-type Plasmodium falciparum (3D7) with an IC50 of 8 nM over 72 hours, whereas the PfATP6 F972Y mutant strain (E4) shows significant drug resistance with an IC50 reaching 5 μM. SC83288 at 100 nM for 15 minutes is transported in an ATP-dependent manner by PfATP6, particularly targeting the PfATP6 F972Y mutant, which exhibits enhanced transport efficiency subject to competitive inhibition by Ca2+. The compound at 50 nM over 0-60 minutes is taken up about 100-fold by wild-type 3D7 strain and E4 mutant-infected red blood cells via new permeation pathways induced by the parasite, with no difference observed between the two strains. At 30 nM for 0-52 hours, SC83288 interrupts DNA replication when administered from early ring to trophozoite stages in wild-type Plasmodium falciparum Dd2 and 3D7 blood-stage parasites, though it is ineffective against the E4 (PfATP6 F972Y mutant) strain. Treatment with SC83288 at 5-10 nM for 4.5 hours induces upregulation of gene transcription linked to epigenetic regulation, mitosis, and stress response in Plasmodium falciparum 3D7 trophozoites. When applied at 40 nM for 12 hours, SC83288 disrupts methylation-related metabolism in Plasmodium falciparum 3D7 trophozoites but has no effect on the E4 (PfATP6 F972Y mutant) lineage. SC83288 at 80 nM for 4 hours reduces global RNA m6A and DNA m5C methylation levels in trophozoites and inhibits DNA methyltransferase activity, which can be reversed by SAM.
In vivo	SC83288 (5 mg/kg; administered daily for 3 consecutive days) effectively cures malignant Plasmodium falciparum infections in humanized NOD/SCID mice.

Chemical Properties

Molecular Weight	629.71
Formula	C₂₇H₃₁N₇O₇S₂
Cas No.	1237645-43-0
Smiles	O=C(OC)N1CCN(C(=N)C=2C=CC=C(C2)NC(=O)NC3=CC=C(C=C3)S(=O)(=O)NCC4=CC=C(C=C4)S(=O)(=O)N)CC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: SC83288 in vivo | SC83288 in vitro | SC83288 formula | SC83288 molecular weight