mr

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).

MR 2266 is a narcotic antagonist.

MR-1452 is a kappa opiate receptor antagonist. FOR RESEARCH USE ONLY

MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.

Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) is an IgG1, κ inhibitor antibody derived from mouse, designed to target and inhibit mouse CD40L/CD154.

Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) is an IgG2a, κ inhibitory antibody derived from mice, specifically targeting murine CD40L/CD154.

Parcetasal (MR-897) is a non-steroidal anti-inflammatory agent that can be used in pain relief studies.

Pyridoclax is an inhibitor of potential Mcl-1.

JM-1232 is a sedative and hypnotic drug being researched as a potential anesthetic.

trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.

Thioperamide maleate (MR-12842 maleate) is an effective and selective H3 receptor antagonist (Ki = 4.3 nM) that inhibits [3H]histamine synthesis (Ki = 31 nM).

MR 409, a selective growth hormone-releasing hormone (GHRH) agonist, exhibits notable neuroprotective properties by augmenting endogenous neurogenesis in cerebral ischemic mice and demonstrates the ability to inhibit in vivo lung cancer growth [1] [2] [3] [4].

MR-2-93-3, a long-chain fatty acid, functions as a carrier for polynucleotides [1].

MR-2088 is a selective inhibitor of ULK1 and ULK2, with pEC50 values of 8.3 and 8.7, respectively. It effectively inhibits autophagy by targeting ULK1/2-mediated pathways [1].

Anti-Mouse CD40L/CD154 Antibody (MR-1) is an IgG antibody inhibitor derived from an American hamster, specifically targeting mouse CD40L/CD154.

Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.

stimulates the release of acetylcholine from synaptosomes

MR2034 is an agonist of kappa-Opioid receptor. MR2034 stimulates hypothalamic-pituitary-adrenal axis.

MR44397 is a ligand for WD40 repeat (WDR) 5 and is applicable in cancer research.

MR24 is a derivative of G-5555 and acts as an inhibitor of mammalian STE20-like (MST) kinases. It selectively targets MST3 and MST4, with EC50 values of 57 nM and 583 nM, respectively.

MR33317 is an inhibitor of acetylcholinesterase with an IC50 value of 41 nM. Additionally, it acts as an agonist for brain 5-HT4 receptors.

MR2938 is a potent AChE inhibitor (IC50 = 5.04 μM). MR2938 significantly inhibits the production of NO (IC50 = 3.29 μM). MR2938 inhibits neuroinflammation by blocking the MAPK/JNK and NF-κB signaling pathways and can be used for Alzheimer's disease (AD) research.

MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.

MRTX-1719 is a potent and selective inhibitor of the PRMT5/MTA complex with an IC50 value of <10 nM against PRMT5/MTAMTAPDELSDMA cell lines.