mr

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).

MR 2266 is a narcotic antagonist.

MR-1452 is a kappa opiate receptor antagonist. FOR RESEARCH USE ONLY

Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) is an IgG1, κ inhibitor antibody derived from mouse, designed to target and inhibit mouse CD40L/CD154.

Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) is an IgG2a, κ inhibitory antibody derived from mice, specifically targeting murine CD40L/CD154.

Parcetasal (MR-897) is a non-steroidal anti-inflammatory agent that can be used in pain relief studies.

Pyridoclax is an inhibitor of potential Mcl-1.

trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.

Thioperamide maleate (MR-12842 maleate) is an effective and selective H3 receptor antagonist (Ki = 4.3 nM) that inhibits [3H]histamine synthesis (Ki = 31 nM).

MR 409, a selective growth hormone-releasing hormone (GHRH) agonist, exhibits notable neuroprotective properties by augmenting endogenous neurogenesis in cerebral ischemic mice and demonstrates the ability to inhibit in vivo lung cancer growth [1] [2] [3] [4].

MR-2088 is a selective inhibitor of ULK1 and ULK2, with pEC50 values of 8.3 and 8.7, respectively. It effectively inhibits autophagy by targeting ULK1/2-mediated pathways [1].

MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.

Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.

stimulates the release of acetylcholine from synaptosomes

MR2034 is an agonist of kappa-Opioid receptor. MR2034 stimulates hypothalamic-pituitary-adrenal axis.

MR-2-93-3, a long-chain fatty acid, functions as a carrier for polynucleotides [1].

MR44397 is a ligand for WD40 repeat (WDR) 5 and is applicable in cancer research.

MR24 is a derivative of G-5555 and acts as an inhibitor of mammalian STE20-like (MST) kinases. It selectively targets MST3 and MST4, with EC50 values of 57 nM and 583 nM, respectively.

MR33317 is an inhibitor of acetylcholinesterase with an IC50 value of 41 nM. Additionally, it acts as an agonist for brain 5-HT4 receptors.

MR2938 is a potent acetylcholinesterase (AChE) inhibitor, evidenced by an IC50 value of 5.04 μM, and significantly inhibits nitric oxide (NO) production with an IC50 of 3.29 μM. Additionally, it mitigates neuroinflammation by blocking the MAPK/JNK and NF-κB signaling pathways, making it a promising compound for Alzheimer's disease (AD) research.

MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.

MRTX-1719 is a potent and selective inhibitor of the PRMT5/MTA complex with an IC50 value of <10 nM against PRMT5/MTAMTAPDELSDMA cell lines.

HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively).

MRE3008F20 is a species-selective and potent adenosine A3 receptor (AA3R) antagonist that inhibits Cl-IB-MECA-induced cAMP production and can be used in glaucoma and asthma studies.13483-88-88-9