gc 1

Sobetirome (IACS-010759) is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).

Anti-GC1q R/C1QBP Antibody (60.11) is a mouse IgG1, κ chimeric antibody designed to target human GC1q R/C1QBP. The recommended isotype control for this antibody is Mouse IgG1 kappa, Isotype Control.

C18:0 GM2(Neu5Gc) Ceramide (d18:1/18:0) is a type of sphingolipid.

C18:0 GM3(Neu5Gc) Ceramide (d18:1/18:0) is a type of sphingolipid.

C18:0 GM1(Neu5Gc) Ceramide (d18:1/18:0) is classified as a ganglioside.

GC 14 is a selective thyroid hormone receptor antagonist with IC50 values of 200 nM for hTRα and 35 nM for hTRβ.

GC 10284 is an agent of pesticide.

CGC 11093 is a polyamine analog; inhibits growth of human prostate tumor xenografts in nude mice. It may prove useful in promoting regression of choroidal neovascularization.

CGC 11150 is a polyamine analogue inhibit tumor growth in vitro and in vivo.

CGC 11144 is a Polyamine analogue inhibit tumor growth in vitro and in vivo.

NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.

PG-11047 2HCl is an apoptosis-stimulating agent used in the treatment of genitourinary disorders, immune system disorders, genetic disorders and malformations, ocular disorders, and disorders of the blood and lymphatic systems, and in the study of lymphomas and prostate cancer.

D-Mannitol (Mannitol) is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. D-Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.

ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α.

ZLN005 (hydrochloride) is an activator of the peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α). It enhances the expression of PGC-1α and downstream genes in skeletal muscle cells, leading to improved glucose utilization and fatty acid oxidation. In diabetic db/db mice, ZLN005 (hydrochloride) elevates the transcription of PGC-1α and downstream genes in skeletal muscle, boosts fat oxidation, and enhances glucose tolerance, pyruvate tolerance, and insulin sensitivity.

NCGC1481 is a potent inhibitor of FLT3 and IRAK1/4 with improved stability, solubility, and permeability properties.

SR-18292 is an inhibitor of PPAR gamma coactivator-1α (PGC-1α), which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.

CGC-11047 free base is a second generation polyamine analogue of N1, N12-bisethylspermine (BESpm).

Ac-SVVVRT-NH2, a PGC-1α modulator, enhances the activity of the human PGC-1α promoter (114%), elevates PGC-1α mRNA levels (125%), and promotes intracellular lipid accumulation (128%) in subcutaneous human adipocytes. This compound has potential applications in research related to diseases influenced by PGC-1α.

PG-11047 (CGC-11047) is a polyamine analogue used in breast cancer research.

Mogroside VI B, a cucurbitane glucoside derived from Siraitia grosvenorii crude extract, exhibits potency in activating PGC-1α transcription [1].

Fresolimumab (GC1008) is a specific human anti-transforming growth factor β monoclonal antibody that binds to the active forms of human TGFβ1, TGFβ2, and TGFβ3 and can be used to study focal segmental glomerulosclerosis and cancer in adults.

11-Oxoisomogroside V (compound 3), a cucurbitacin derived from Luo Han Guo extract, enhances the transcriptional activity of PGC-1α. Luciferase assay data demonstrates that at concentrations of 10 μM and 20 μM, 11-Oxoisomogroside V increases luciferase activity to 133.79% and 143.81%, respectively [1].

Phoenixin-20 (PNX-20) is a vertebrate bioactive peptide with hormone-like actions, stimulating the hypothalamo-pituitary-gonadal axis to regulate mammalian reproduction, enhancing neuronal mitochondrial biogenesis via the CREB-PGC-1α pathway, and possessing an anxiolytic effect [1] [2] [3].