ligase

Lenalidomide (CC-5013) is an immunomodulator with oral activity. Lenalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN), which selectively ubiquitinates and degrades two lymphoid transcription factors, IKZF1 and IKZF3, via the CRBN-CRL4 ubiquitin ligase, and is commonly used in the synthesis of PROTAC products.

E3 ligase Ligand 23 is a cereblon binding agent that degrades Ikaros or Aiolos via the ubiquitin proteasome.

E3 ligase Ligand 8, a ligand for E3 ubiquitin ligase, can be connected to protein ligands through linkers to form PROTACs, which induce ubiquitination-mediated degradation of cancer-promoting proteins.

E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated degradation, specifically targeting cancer-promoting proteins[1].

E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand that can be employed to create PROTACs, which are connected to the ligand for the protein through a linker. PROTACs serve as inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

E3 ligase Ligand 14 binds to E3 ubiquitin ligase and, when conjugated to a protein ligand via a linker, forms PROTACs that facilitate the ubiquitination-mediated degradation of cancer-promoting proteins[1].

E3 ligase Ligand 18 is a compound that binds to E3 ubiquitin ligase and can be chemically linked to a protein ligand via a linker to form PROTACs, which induce ubiquitination-mediated degradation of cancer-promoting proteins [1].

E3 ligase Ligand 9 is a compound that acts as a ligand for E3 ubiquitin ligase and can be attached to a protein ligand via a linker to form PROTACs or SNIPERs, which degrade cancer-promoting proteins through ubiquitination-mediated mechanisms[1].

E3 Ligase Ligand-linker Conjugate 114, a conjugate of an E3 ubiquitinase ligand and linker, facilitates the synthesis of PTOTAC HSD17B13 degrader 1.

E3 Ligase Ligand-linker Conjugate 116, an E3 ubiquitinase ligand plus linker conjugate (E3 Ligase Ligand-Linker Conjugates), facilitates the synthesis of PROTAC SMARCA2 4-degrader-28.

E3 Ligase Ligand-linker Conjugate 118, an E3 ubiquitinase ligand plus linker conjugate (E3 Ligase Ligand-Linker Conjugates), serves as a precursor for synthesizing PROTAC SMARCA2 4-degrader-30.

E3 Ligase Ligand-linker Conjugate 112, a type of E3 ubiquitinase ligand-linker conjugate, serves as a precursor for the synthesis of SMARCA2 degrader-10.

E3 Ligase Ligand-linker Conjugate 136 is an E3 ubiquitin ligase ligand-linker conjugate (E3 Ligase Ligand-linker conjugate) used for the synthesis of c-Myc inhibitor7.

E3 Ligase Ligand-linker Conjugate 137 serves as both a linker and an E3 ligase ligand for PROTAC METTL3-14 degrader 1, employed in the study of acute myeloid leukemia.

E3 Ligase Ligand-linker Conjugate 139 is an E3 ubiquitin ligase ligand and linker for PROTACKB03-SLF, used in cancer research.

E3 Ligase Ligand-linker Conjugate 133 is a critical intermediate in the synthesis of the complete PROTAC molecule CPD-39, comprising a conjugate (conjugate of E3 ligase Ligand and linker) that connects the E3 ligase ligand with a linker.

E3 Ligase Ligand-linker Conjugate 131 serves as a crucial intermediate in the synthesis of the complete PROTAC molecule CPD-39; it represents a (conjugate of E3 ligase Ligand and linker). This compound is vital for bridging the components necessary for forming the active PROTAC structure.

E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.

E3 Ligase Ligand-linker Conjugate 126 is an E3 ligase ligand-linker conjugate designed for the synthesis of PROTACs, such as PROTAC BRM BRG1 degrader-1.

E3 Ligase Ligand 43 is an E3 ubiquitin ligase ligand for ACBI3, used in the synthesis of PROTACs.

E3 Ligase Ligand-linker Conjugate 134 is a crucial intermediary in synthesizing the complete PROTAC molecule STING-IN-10. It consists of a conjugate of an E3 Ligase Ligand and a linker, which facilitates the assembly of the target molecule.

E3 Ligase Ligand-linker Conjugate 129 is an E3 ubiquitin ligase ligand-linker conjugate (E3 Ligase Ligand-linker conjugate) utilized in the synthesis of DD205-291.

E3 Ligase Ligand 42 is a ligand for E3 ubiquitin ligases. It can be conjugated to target protein ligands via a linker, facilitating the synthesis of PROTACAR Degrader-6. PROTACs induce the ubiquitination and degradation of oncogenic proteins.

E3 Ligase Ligand 38 serves as the E3 ligase ligand for PROTAC IRAK4 Degrader-12, facilitating the synthesis of PROTAC.