s3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T26397	6PGD-IN-S3	6PGD Inhibitor S3,S3,Danthron methyl derivative	Dehydrogenase
	6PGD-IN-S3 (6PGD Inhibitor S3) is an inhibitor of 6-phosphogluconate dehydrogenase (6PGD).		Dehydrogenase
T80311	Dermaseptin-S3
	Dermaseptin-S3 is an antimicrobial peptide originating from frog skin with activity against filamentous fungi [1].
T80253	S3 Fragment
	S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinase (LIMK) phosphorylation. LIMK1, a pivotal regulator of the ac...
T60592	F8-S43-S3
	F8-S43-S3 is a SARS-CoV-2 main protease inhibitor (IC 50 = 9.69 μM) [1].
T16347	NS3623		Potassium Channel
	NS3623 is an activator of human ether-a-go-go-related gene potassium channels. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS3623 activates the IKr and Ito currents and has an antiarrhythmic e...		Potassium Channel
T6945	Vps34-PIK-III	PIK-III,VPS34-IN2	PI3K , Autophagy
	Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.		PI3K , Autophagy
T24270	KS370G	KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide
	KS370G (Caffeic Acid Phenethyl Amide) inhibits UUO-induced renal fibrosis marker expression. KS370G is an orally active hypoglycemic and cardioprotective agent that reduces collagen deposition in obstructed kidneys and s...
T3636	(E)-SIS3	SIS3,SIS3 HCl	TGF-beta/Smad
	(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblas...		TGF-beta/Smad
T61439	DSS30		Beta Amyloid , BACE , CDK
	DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of β-amyloid (Aβ).DSS30 can be used for the prevention and tr...		Beta Amyloid , BACE , CDK
T12111L	MS31 trihydrochloride (2366264-12-0 free base)	MS31 trihydrochloride	Epigenetic Reader Domain
	MS31 trihydrochloride (2366264-12-0 free base) is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor.		Epigenetic Reader Domain
T7944	VPS34 inhibitor 1 (Compound 19, PIK-III analogue)	PIK-III analogue	PI3K
	VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)		PI3K
T21767	MS37452		Others , Histone Methyltransferase
	MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).		Others , Histone Methyltransferase
T9542	NS3861		AChR
	NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-contain...		AChR
T22119	NS3694		Apoptosis
	NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.		Apoptosis
T2505	S3I-201	S3I 201,S3I201	STAT
	S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.		STAT
T13216	TSHR antagonist S37		TSH Receptor
	TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).		TSH Receptor
T81646	NPAS3-IN-1		Others
	NPAS3-IN-1 is a potent inhibitor of NPAS3-ARNT heterodimerization, which regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT at the cellular level.		Others
T15582	InS3-54A18		STAT
	inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.		STAT
T67847	Imatinib impurities3		Bcr-Abl , PDGFR , c-Kit
	Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.		Bcr-Abl , PDGFR , c-Kit
T27613	InS3-54-A26		STAT
	inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.		STAT