22-(tert-butoxy)-22-oxodocosanoic acid

22-(tert-Butoxy)-22-oxodocosanoic acid is an important organic compound for life sciences research, catalog number T64415, CAS number 1642333-05-8.

(Iso)-MS4322 ((Iso)-YS43-22) is a selective and potent protein arginine methyltransferase 5 (PRMT5) degrader with potential anticancer activity that effectively reduces PRMT5 protein levels in MCF-7 cells and inhibits the growth of a wide range of cancer cells.

NH2-C2-NH-Boc (PROTAC Linker 22), an alkyl chain-based PROTAC linker, can be used in the synthesis of PROTACs.

DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively) [1].

2-Bromo-22-dimethyl-acetamido-PEG3-acid is a polyethylene glycol (PEG) derivative commonly used as a PEG-based PROTAC linker in PROTAC synthesis [1].

Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon ligand and 4-unit PEG linker.

HO-PEG22-OH is a PEG-based linker for PROTACs, facilitating selective protein degradation by joining two essential ligands and leveraging the ubiquitin-proteasome system within cells.

Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1]

(S,R,S)-AHPC-Ac serves as a ligand for E3 ubiquitinase and is utilized in the synthesis of PROTAC SMARCA2 4-degrader-22.

PROTAC SMARCA2 degrader-22 (Compound 5) is a PROTAC degrader designed to degrade SMARCA2, achieving a degradation efficacy of 94% at 100 nM. This compound also inhibits the proliferation of A549 cells with an EC50 of less than 250 nM.

Adamantane-Butyl alcohol is a selective and persistent degrader targeting the CDK8-cyclin C complex. It serves as a linker for LL-K8-22 (PROTACCDK8-cyclin C) and HyT.

Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences and is biotinylated via a C-terminal GK linker. Histone H3 (21-44) contains a lysine residue at position 23 that is subject to acetylation, an arginine at position 26 subject to methylation, and a serine at position 28 subject to phosphorylation, as well as lysine residues at positions 27 and 36 that are subject to methylation and acetylation. Histone H3 (21-44)-GK-biotin has been used as a substrate for the primate-specific histone methyltransferase PR domain-containing protein 7 (PRDM7) to determine substrate specificity.

Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence and is biotinylated via a C-terminal GK linker. Unlike histone H3.1 and H3.2, the histone H3.3 variant contains a serine residue at position 31 that is phosphorylated during late prometaphase and metaphase of mitosis. Histone H3 (21-44) also contains lysine residues at positions 23, 27, and 36 that are subject to methylation and acetylation, all of which have a role in the regulation of gene expression, and a serine residue at position 28 that is subject to phosphorylation during mitosis.

4-Boc-amino-22-dimethylbutyric acid is an alkyl ether-derived PROTAC linker, suitable for PROTAC synthesis.

Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate containing a cereblon ligand derived from Thalidomide and a linker used in the synthesis of MI-389 [compound 22], a highly effective phthalimide PROTAC degrader developed from the multi-targeted receptor tyrosine kinase inhibitor sunitinib.

1-Cbz-3-Hydroxyazetidine (catalog number: T66502, CAS number: 128117-22-6) is a valuable organic compound for life sciences research.

KTX-951, a PROTAC designed for IRAK4 degradation (DC 50 =18 nM), exhibits an oral bioavailability (F%) of 22% in a rat model at a dosage of 10 mg kg. Additionally, KTX-951 demonstrates promising anticancer potential [1].

PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based degrader targeting BRD4, with a pDC50 of 9.2 in MOLT4 cells over 24 hours [1].

E3 Ligase Ligand 22 (compound 139) serves as a cereblon binder, facilitating the degradation of Ikaros or Aiolos via the ubiquitin proteasome pathway [1].

22-SLF is a PROTAC degrader that operates by FBXO22-dependent degradation of FK506 Binding Protein 12 (FKBP12) with a DC50 of 0.5 µM. Additionally, 22-SLF can degrade other endogenous proteins, such as BRD4 and the EML4-ALK fusion protein (EML4-ALK fusion protein).

AZ'3137 (Compound 22) is an orally active PROTAC-based androgen receptor (AR) degrader, exhibiting a DC50 value of 22 nM. It inhibits cell proliferation in LNCaP cells with a GI50 of 74 nM. Additionally, AZ'3137 suppresses AR signaling and tumor growth in a prostate cancer mouse model.

HO-CONH-C3-PEG3-NH2 is a linker used in the synthesis of the PROTAC degrader 22-SLF.

Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph is a ligand for the E3 ubiquitin ligase. This compound can form 22-SLF by linking with protein ligands through a connector.

(S,R,S)-AHPC-Ac-CO-cyclohexene-Bpin serves as an E3 Ligase Ligand-Linker Conjugate. This compound is utilized in the synthesis of PROTAC SMARCA2 4-degrader-22.