Natriuretic peptide

Imelciment (REGN-9035) is a humanised monoclonal antibody targeting NPR1, which can be used for research into heart failure.

dCNP binds to NPR-B C receptors (NPR-B C receptor), initiating the cGMP signaling pathway and regulating vascular function. It exhibits anti-hypoxic effects by downregulating hypoxia-related genes such as HIF1α and HIF2α. Additionally, dCNP inhibits tumor stroma induction, demonstrating antifibrotic properties. It also enhances immune response by upregulating CTL, NK cells, and conventional type 1 dendritic cells in tumors.

ANP [Des18-22] 4-23 amide rat is a peptide fragment of rat atrial natriuretic peptide (ANP) that specifically binds to NPR-C.

Baloncibart is a human IgG4K monoclonal antibody that targets NPR1.

REGN-7544 is a humanised monoclonal antibody targeting NPR1, which blocks and inhibits NPR1 to increase blood pressure, and can be used for research into hypotension, septic shock, and postural tachycardia syndrome.