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Inhibitors & Agonists

Angiogenesis
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lysosomal autophagy
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Wee1
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Epigenetic Reader Domain
HDAC
HIF
HIF/HIF Prolyl-Hydroxylase
Histone Acetyltransferase
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HuR
JAK
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PAD
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Pim
PKC
Sirtuin
Akt
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Dynamin
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Gap Junction Protein
HSP
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Kinesin
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Myosin
PAK
PKC
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Wnt/beta-catenin
ATM/ATR
BMI-1
CRISPR/Cas9
DHFR
DNA
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GPR
LHRH
Opioid Receptor
Oxytocin Receptor
RAAS
Reductase
Thyroid hormone receptor(THR)
5-HT Receptor
Adenosine Receptor
Adiponectin receptor
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Amylin Receptor
Annexin A
Apelin receptor
Arrestin
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Bradykinin Receptor
cAMP
Cannabinoid Receptor
CaSR
CGRP Receptor
cholecystokinin
CRFR
CXCR
Dopamine Receptor
EBI2/GPR183
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GHSR
Glucagon Receptor
GNRH Receptor
GPCR19
GPR
GRK
GTPase
Guanylate cyclase
Hedgehog/Smoothened
Histamine Receptor
Kisspeptin
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LPA Receptor
LPL Receptor
Melanin-concentrating Hormone Receptor (MCHR)
Melanocortin Receptor
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Motilin Receptor
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Neurotensin Receptor
Opioid Receptor
OX Receptor
Oxytocin Receptor
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PACAP
PAFR
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Protease-activated Receptor
RXFP receptor
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SGLT
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IRAK
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MyD88
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IDO
Indoleamine 2,3-Dioxygenase (IDO)
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LDL
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Lipoxygenase
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MAGL
MAO
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N-Acetylglucosaminyltransferase
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NAMPT
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PAI-1
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PPAR
Procollagen C Proteinase
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stilbene oxidase
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transporter
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GluCls
HBV
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Influenza Virus
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Ribosome
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AAK1 (AP2 associated kinase 1)
AChE
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Adenosine Receptor
Adenylyl cyclase
Adrenergic Receptor
BACE
Beta Amyloid
Beta-Secretase
CaMK
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COX
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FAAH
GABA Receptor
Gamma-secretase
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GlyT
Histamine Receptor
Huntingtin
iGluR
Imidazoline Receptor
MAO
Melanocortin Receptor
Monoamine Oxidase
MT Receptor
Neurokinin receptor
Neuropeptide W
Neuropeptide Y Receptor
NMDAR
NMU2R
Norepinephrine
Opioid Receptor
OX Receptor
P2X Receptor
P2Y Receptor
P-gp
Serotonin Transporter
IRAK
IκB/IKK
NF-κB
NOD
RANKL/RANK
Reactive Oxygen Species
RIP kinase
advanced glycation end products
CYP19A1
Decarboxylase
DprE1
Fer/FerT kinase
Others
Platelet aggregation
Progesterone Receptor
Antioxidant
Free radical scavengers
Glutathione reductase
GPX
GST
Akt
AMPK
ATM/ATR
DNA-PK
GSK-3
MELK
mTOR
PDK
PI3K
PI4K
PTEN
S6 Kinase
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ATTECs
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E3 Ligase Ligand-Linker Conjugate
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Molecular Glues
PROTAC Linker
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Target Protein Ligand-Linker Conjugate
Carboxypeptidase
Caspase
Cysteine Protease
DPP-4
Gamma-secretase
Glutaminase
HCV Protease
HIV Protease
MMP
Prolyl Endopeptidase (PREP)
Protease
Proteasome
Serine Protease
Thrombin
Tyrosinase
Casein Kinase
Gamma-secretase
GSK-3
Hedgehog/Smoothened
Hippo pathway
JAK
Porcupine
ROCK
Smo
STAT
Stemness kinase
TGF-beta/Smad
Wnt/beta-catenin
YAP
ACK
ALK
Bcr-Abl
BTK
c-Fms
c-Kit
c-Met/HGFR
c-RET
CSF-1R
Discoidin Domain Receptor (DDR)
DYRK
EGFR
Ephrin Receptor
FAK
FGFR
FLT
Hck
HER
IGF-1R
PDGFR
PKA
PYK2
ROS Kinase
Src
Syk
TAM Receptor
Tie-2
Trk receptor
Tyrosine Kinases
VEGFR
DUB
E1/E2/E3 Enzyme
p97
Proteasome
PROTAC-Linker Conjugates for PAC
Drug-Linker Conjugates for ADC
Antibody-Drug Conjugates (ADCs)
ADC Linker
ADC Cytotoxin
ADC Antibody

Compound Libraries

Focused Bioactive Libraries
Natural Product Libraries
Fragment Libraries
Drug-like Compound Libraries
Research Field

General Bioactive Libraries
Approved / Repurposing
Characteristic Bioactive Libraries
Disease Focused
Target / Pathway Focused
Natural Product Derivatives Libraries
Natural Product Library for HTS
Characteristic Natural Product Libraries
TCM Natural Product Library
Activity-classified Natural Product Library
Structure-classified Natural Product Library
Characteristic Fragment Libraries
General Fragment Libraries
Compound Libraries for HTS/HCS
Tumor
Anti-infective
Cardiovascular disease
Development and reproduction
Digestive disorders
Inflammation and immunity
Metabolic diseases
Neurological disorders
Other Fields

Natural Products

Plant
Structure

Alangiaceae
Aquifoliaceae
Cephalotaxaceae
Costaceae
Daphniphyllaceae
Dioscoreaceae
Eucommiaceae
Ginkgoaceae
Hippocastanaceae
Illiciaceae
Lycopodiaceae
Moringaceae
Myricaceae
Myristicaceae
Nelumbonaceae
Nothofagaceae
Nyssaceae
Orobanchaceae
Paeoniaceae
Piperaceae
Podocarpaceae
Pteridaceae
Resedaceae
Sapindaceae
Schisandraceae
Stemonaceae
Theaceae
Other
Alkaloids
Coumarins
Flavonoids
Lignans
Others
Phenols
Phenylpropanoids
Quinones
Saccharides and Glycosides
Steroids
Terpenoids

Recombinant Proteins

CAR-T Therapy Target Proteins
CD Proteins
Complement System
Cytokines and Growth Factors
Enzymes
Fluorescent Proteins
Hormones
Immune Checkpoint Proteins
Others
Receptor Proteins
Viral Proteins

Hematologic Malignancies Target Proteins
Solid Tumors Target Proteins
B Cell CD Proteins
Cell Activation CD Proteins
Cell Adhesion CD Proteins
Cytokine Receptor CD Proteins
Endothelial Cell CD Proteins
Myeloid Cell CD Proteins
NK/Non-lineage Cell CD Proteins
Other CD Proteins
Platelet CD Proteins
T Cell CD Proteins
Cytokines
Epidermal Growth Factor Family, EGFs
Growth Factors
Others
Hydrolases,EC 3
Isomerases,EC 5
Ligases or Synthetases,EC 6
Lyases,EC 4
Oxidoreductases,EC 1
Transferases,EC 2
Translocases,EC 7
Butyrophilins
Co-inhibitory Immune Checkpoint Proteins
Co-stimulatory Immune Checkpoint Proteins
Cell Adhesion Receptors
Cytokines and Growth Factor Receptors
Enzyme-Linked Receptors
Fc Receptors
G Protein-Coupled Receptors, GPCRs
Ion Channel-Linked Receptors
Nuclear Receptors
Receptor Serine/Threonine Kinases
Receptor Tyrosine Kinases
Others
Coronavirus (CoV) Proteins
DENV Proteins
EBOV Proteins
HBV Proteins
HCV Proteins
HIV Proteins
Influenza Proteins
RSV Proteins
Others

Technical Services

Technical Services

Molecular Docking
Virtual Screening
Biomolecular Interaction
Custom Synthesis
AI-driven Ultra High-throughput Virtual Screening

Transmembrane Glycoprotein

Transmembrane Glycoproteins are membrane proteins embedded or spanning the cell membrane, bearing covalently attached sugar chains on their outer surface. They function as receptors, adhesion molecules, transporters, and enzymes, participating in diverse processes including lipid metabolism, immune recognition, signal transduction, and cell adhesion.

Filter HomeSignaling PathwaysNeuroscienceTransmembrane Glycoprotein

WSF1-IN-1

T399472379577-82-7

WSF1-IN-1 is an orally bioavailable small-molecule inhibitor of the WSF1 protein, designed for the investigation of WSF1-associated tumorigenesis in Wolfram syndrome. in studies using HepG2 parental and HepG2 WFS1 knockout cell lines, WSF1-IN-1 demonstrated differential inhibitory potency with IC50 values of 0.33 μM, confirming its target selectivity and mechanistic specificity in modulating WSF1-related cellular pathways.