MRGPR

BAM (8-22) acetate is a proteolytically cleaved product of proenkephalin A. BAM (8-22) acetate activates Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr-dependent manner.

ML382 is a potent and selective MrgX1 positive allosteric modulator(EC50 : 190 nM).

(R)-ZINC-3573 is a potent and highly selective MRGPRX2 probe. (R)-ZINC-3573 activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release.

MRGPRX4 modulator-2 is a potent modulator of Mas-related G protein receptor X4 (MRGPR X4).MRGPRX4 modulator-2 can be used to study autoimmune diseases and inflammation.

MrgprX2 antagonist-8 is an MrgprX2 antagonist that can be used to study inflammatory diseases.

MRGPRX1 agonist 1 is a highly potent MRGPRX1 (Mas-related G-protein-coupled receptor X1)agonist(EC50 of 50 nM).