Glutaminyl Cyclase

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Neuroscience

AAK1 (AP2 associated kinase 1)

Melanocortin Receptor

Neuropeptide Y Receptor

Serotonin Transporter

(173)

Transmembrane Glycoprotein

(12)

iGluR

(564)

Glutaminyl Cyclase

Glutaminyl Cyclase (QC) is an enzyme that catalyzes the conversion of N-terminal glutamine (Gln) or glutamic acid (Glu) residues into pyroglutamate (pGlu) through cyclization. This modification enhances the stability and bioactivity of proteins and peptides. QC plays a critical role in the formation of pyroglutamate-modified amyloid-β (pGlu-Aβ), which is implicated in Alzheimer's disease and other neurodegenerative disorders. It is considered a potential therapeutic target for diseases involving pGlu-modified peptides.

Glutaminyl Cyclase Inhibitor 1

T114242110449-60-8In house

Glutaminyl Cyclase Inhibitor 1, a glutaminyl cyclase inhibitor with an IC50 of 0.5 μM, can be utilized for studying neurological disorders.

Beta Amyloid Glutaminyl Cyclase

$122

In Stock

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PBD-150

T7905790663-33-1

PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)

Beta Amyloid Glutaminyl Cyclase

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Glutaminyl Cyclase Inhibitor 3

T114222092921-50-9

Glutaminyl Cyclase Inhibitor 3, a designed anti-Alzheimer's compound, is a potent human Glutaminyl Cyclase (GC) inhibitor (IC50: 4.5 nM). It significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions.

Beta Amyloid Glutaminyl Cyclase

$1,970

10-14 weeks

Size

QTY

Glutaminyl Cyclase Inhibitor 5

T72136

Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) of 3.2 nM.

Beta Amyloid Glutaminyl Cyclase