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5,7-Dihydroxytryptamine creatinine sulfate
(Synonyms: 5,7-DHP creatinine sulfate) Copy Product Info
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Synonyms: 5,7-DHP creatinine sulfate
Catalog No. T218823 Copy Product Info
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5,7-Dihydroxytryptamine (5,7-DHT) is a selective neurotoxin with luminescent properties and acts as a substrate for monoamine oxidase A (MAO-A) and serotonin (5-HT) transport. It specifically targets and damages serotonergic neurons in both central and peripheral systems, affecting serotonin-related pathways and neurotransmitter balance. This compound is utilized to establish models of serotonergic neuron injury, aiding research into neurodevelopment, neurodegenerative diseases, platelet function, and retinal neuron mechanisms.
5,7-Dihydroxytryptamine creatinine sulfate
Cas No. 39929-27-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 5,7-Dihydroxytryptamine (5,7-DHT) is a selective neurotoxin with luminescent properties and acts as a substrate for monoamine oxidase A (MAO-A) and serotonin (5-HT) transport. It specifically targets and damages serotonergic neurons in both central and peripheral systems, affecting serotonin-related pathways and neurotransmitter balance. This compound is utilized to establish models of serotonergic neuron injury, aiding research into neurodevelopment, neurodegenerative diseases, platelet function, and retinal neuron mechanisms. |
| In vitro | 5,7-Dihydroxytryptamine (25 μM; 60 min) creatinine sulfate specifically targets serotonergic cells, excluding dopaminergic cells, in primary mesencephalic cultures derived from 14-day-old Wistar rat fetuses at 10 days of age. |
| In vivo | 5,7-Dihydroxytryptamine (12.5-50.0 μg; intracerebral administration; single dose) in the form of creatinine sulfate depletes norepinephrine and 5-HT in the mouse hippocampus. The norepinephrine depletion can be blocked by non-selective MAO inhibition, but not by selective MAO-B inhibition. Additionally, 5,7-Dihydroxytryptamine (10 µg base; lateral ventricle injection; single administration; 10 days before convulsion induction) creatinine sulfate depletes 5-HT levels in the rat spinal cord without affecting electrically induced spinal convulsions in rats. |
| Synonyms | 5,7-DHP creatinine sulfate |
| Molecular Weight | 403.41 |
| Formula | C14H21N5O7S |
| Cas No. | 39929-27-6 |
| Smiles | O=C1N=C(N)N(C)C1.O=S(=O)(O)O.OC=1C=C(O)C=2NC=C(C2C1)CCN |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: 5,7-Dihydroxytryptamine creatinine sulfate in vivo | 5,7-Dihydroxytryptamine creatinine sulfate in vitro | 5,7-Dihydroxytryptamine creatinine sulfate formula | 5,7-Dihydroxytryptamine creatinine sulfate molecular weight
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