293
204
138
7
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5116 | Iprodione | Others , Reactive Oxygen Species , Antifungal | |
Iprodione is a fungicide. Iprodione is also used in cannabis testing kits as a component of pesticide mixes. | |||
T25049 | Allethrin | BCL , Caspase | |
Allethrin induces oxidative stress, apoptosis and calcium release. Allethrin, a pyrethroid insecticide is a major mosquito repellent agent. | |||
T7845 | BTZO-1 | Apoptosis | |
BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity. | |||
T0734 | Antipyrine | Phenazone,Phenazon | COX |
Antipyrine (Phenazone), an antipyretic and analgesic, has been given as ear drops and by mouth. Antipyrine is frequently used to test the effects of other diseases or drugs on drug-metabolizing enzymes in the liver. | |||
T7042 | 1,5-Isoquinolinediol | PARP | |
1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol... | |||
T8391 | Cesium chloride | CsCl | Potassium Channel |
Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth. | |||
T60034 | TH1085 | Others | |
TH1085 is an enhancer of OGG1. TH1085 stimulates DNA repair and protects cells from the environmental hazard paraquat (PQ). | |||
T8500 | VLX600 | OXPHOS , Mitochondrial Metabolism , Autophagy | |
VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells. | |||
T21902 | ML351 | Lipoxygenase | |
ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM). | |||
T7093 | Rafoxanide | CDK , Parasite | |
Rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer. Rafoxanide is a salicylanilide used as an anthelmintic. It is used to treat fluke, hookworm and other infestations. | |||
T5345 | V-9302 | Others | |
V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM). | |||
T5486 | RU.521 | RU320521 | DNA , cGAS |
RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS. | |||
T14042 | 4-P-PDOT | 4-phenyl-2- propionamidotetralin | Melatonin Receptor , MT Receptor |
4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist. | |||
T5827 | BI-6C9 | Apoptosis , Others , Mitochondrial Metabolism | |
BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death. | |||
T6708 | Tolcapone | Tasmar,Ro 40-7592 | Apoptosis , Beta Amyloid , Transferase |
Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa. | |||
T9211 | Mito-LND | Mito-Loidamine | OXPHOS , Reactive Oxygen Species , Mitochondrial Metabolism , Autophagy |
Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation. | |||
T0412 | Idebenone | CV-2619 | Apoptosis , Antioxidant , Mitochondrial Metabolism |
Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). | |||
T23550 | YM-750 | YM 750 | Acyltransferase |
YM-750 is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with an IC50 value of 0.18 μM. ACAT is an enzyme that catalyzes the conversion of cholesterol and long-chain fatty-acyl-coenzyme A into cholest... | |||
TP1929L1 | Saralasin acetate(34273-10-4 free base) | RAAS | |
Saralasin acetate is a Non-selective angiotensin II antagonist. | |||
T5337 | IACS-010759 | IACS-10759,IACS 10759,IACS10759 | Apoptosis , Others , Mitochondrial Metabolism |
IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain. | |||
T40192 | DGTP | 2'-Deoxyguanosine-5'-triphosphate | Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis |
dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP. | |||
T5371 | L-BUTHIONINE-(S,R)-SULFOXIMINE | L-Butionine sulfoximine | Others , Ferroptosis |
L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH. | |||
T39308 | Boc-Asp(OMe)-fluoromethyl ketone | Boc-Asp(OMe)-fluoromethyl ketone,Boc-Asp(OMe)-FMK | Caspase |
Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) is a broad range caspase inhibitor. Boc-Asp(OME)-Fluoromethyl Ketone inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemot... | |||
T13920L | Terlipressin Acetate | Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous | Vasopressin Receptor |
Terlipressin Acetate, a highly selective vasopressin V1 receptor agonist, on oxygen and glucose deprivation/re-oxygenation (OGD/R)-induced damage in intestinal epithelial cells (IEC-6).Terlipressin acetate exerts anti-in... | |||
T23146 | PHA 568487 free base | PHA 568487 | AChR |
The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia... | |||
T6170 | Elesclomol | STA-4783 | Apoptosis , HSP , Reactive Oxygen Species |
Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-medi... | |||
T9516 | Binodenoson | WRC 0470,MRE-0470,2-(cyclohexylmethylidenehydrazino)adenos | Adenosine Receptor |
Binodenoson (WRC 0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stres... | |||
T22309 | 2,5-Dimethyl-3(2H)-furanone | 2,5-Dimethyl-2,3-dihydrofuran-3-one | Others |
2,5-Dimethyl-3(2H)-furanone (2,5-Dimethyl-2,3-dihydrofuran-3-one) is a non-genotoxic flavoring substance [1]. | |||
T1487 | Fluvastatin sodium | XU 62320 sodium,XU-62-320,Fluvastatin sodium salt | Ferroptosis , HMG-CoA Reductase , Autophagy |
Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent. | |||
T20684 | 2',7'-Dichlorofluorescein diacetate | Diacetyldichlorofluorescein,Leuco-dcf diacetate,Dcfh-DA,DCFDA | Others |
2',7'-Dichlorofluorescein diacetate (Diacetyldichlorofluorescein), a cell-permeable fluorogenic probe, is useful for the detection of nitric oxide (NO) and reactive oxygen species (ROS) and for the determination of the d... | |||
T8842 | IMT1B | 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974 | Others , DNA/RNA Synthesis |
IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of the mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression. This action confers it... | |||
T10512 | Prenyl-IN-1 | Transferase | |
Prenyl-IN-1 is a potent and selective prenylation inhibitor of geranylgeranyltransferase or farnesyltransferase.Prenyl-IN-1 shows anti-oxidative stress effects in a Parkinson's model. Prenyl-IN-1 showed anti-oxidative st... | |||
T2225 | 4-Hydroxyantipyrine | COX | |
4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine. | |||
T20543 | Flurochloridone | R 40244,R-40244,R40244,EPA Pesticide Chemical Code 128401 | Apoptosis , Reactive Oxygen Species |
Flurochloridone (R 40244) is a selective herbicide. Flurochloridone induces apoptosis and is regulated by mitochondrial dysfunction and oxidative stresses. | |||
T25441 | Fructosylvaline | Fru-val,N-Fructosyl Valine | Others |
Fructosylvaline(Fru-val) is present in miso, white wine and sake and has been associated with oxidative browning of white wine and sake. | |||
T21899 | Misonidazole | SR-1354,SR1354,Ro 7-0582 | GPX |
Misonidazole as a novel GPX inhibitors to cause oxidative stress in chemotherapy-resistant tumors. | |||
T18976 | Dihydrofluorescein diacetate | Diacetyldihydrofluorescein | Others |
Dihydrofluorescein diacetate (Diacetyldihydrofluorescein) is a fluorescent probe for measuring oxidative stress in cell-free systems and cellular models. | |||
T13436 | (E)-[6]-Dehydroparadol | (6)-Dehydroparadol | Nrf2 |
(E)-[6]-Dehydroparadol ((6)-Dehydroparadol), an oxidative metabolite of [6]-Shogaol, is a potent Nrf2 activator. | |||
T5913 | Sulbutiamine | Bisibuthiamine | Antioxidant |
Sulbutiamine (Bisibuthiamine) is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death. | |||
T20318 | Benzylideneaniline | N-Benzylideneaniline | Others |
Benzylideneaniline (N-Benzylideneaniline) is a potent inhibitor of xyloglucan-α,β-dioxygenase, a key enzyme in the oxidative cleavage of the central double bond of xyloglucan. | |||
T12059L | Mitoquinone mesylate | MitoQ mesylate,MitoQ10 mesylate | Reactive Oxygen Species |
Mitoquinone mesylate (MitoQ10 mesylate) is a TPP-based, mitochondrially targeted antioxidant to protect against oxidative damage. | |||
T22963 | McN-A 343 | AChR | |
McN-A 343 is a selective M1 muscarinic agonist known for its ability to stimulate muscarinic transmission in sympathetic ganglia. It has been found to effectively reduce inflammation and oxidative stress in experimental ... | |||
T15373 | Gboxin | ATPase , Mitochondrial Metabolism | |
Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity. | |||
T1710 | Trolox | Apoptosis , Antioxidant , Ferroptosis , Reactive Oxygen Species | |
Trolox is a vitamin E analogue, used in reducing oxidative stress or damage. | |||
T12019 | Methylproamine | Others | |
Methylproamine is a DNA-binding radioprotector , acts by repair of transient radiation-induced oxidative species on DNA. | |||
T6834 | FCCP | Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone | ATPase , Mitochondrial Metabolism |
FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer. | |||
T34076 | Piprozolin | W3699,W-3699,W 3699 | |
Piprozolin (W 3699) is a new type of choleretic acid that shows slight analgesic properties at high doses during chronic experiments.Piprozolin has a slight induction of certain enzymes of the oxidative system. | |||
T5837 | Tamerit | Others | |
Tamerit as an efficient inhibitor of oxidative burst in monocytes. | |||
T72082 | Compound T72082(SC) | ROS | |
ROS-IN-1 is a mitochondrial ROS inhibitor that can be used to reduce oxidative stress or inhibit reactive oxygen species (ROS) production. | |||
T24905 | TT01001 | TT-01001,TT 01001,Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate | Mitochondrial Metabolism |
TT01001 (Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate) is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 c... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2738 | Dehydroandrographolide | NOS , Influenza Virus | |
Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees. | |||
TC0039 | Vasicinone | Others | |
Vasicinone may act as a hepatoprotective agent. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to treat respiratory disease.(S)-Vasicinone exhibits antiprolifer... | |||
T2S1720 | Huperzine B | AChE | |
1. Huperzine-B is a efficient inhibitor of human brain AChE. 2. Huperzine-B can enhance ognitive and protect neuro, may be potentially new drug candidates for Alzheimer's disease therapy. | |||
T7982 | 3,6-Dihydroxyflavone | Others | |
3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway. | |||
T5783 | Rosamultin | Antioxidant , HIV Protease | |
Rosamultin has antioxidant, antiinflammatory/antinociceptive properties,and has anti-human immunodeficiency virus (HIV) activity. | |||
T13795 | Nicotinamide riboside | Sirtuin | |
Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. | |||
T8678 | Naphthazarin | 5,8-Dihydroxy-1,4-naphthoquinone,DHNQ | Apoptosis |
Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, inter... | |||
T41358 | 2-Hydroxybenzylamine | Others | |
2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts. 2-Hydroxybenzylamine may be used to decrease early recurrence of atrial fibrillation and other atrial a... | |||
TN2100 | Pratensein | Others , NF-κB | |
Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells. | |||
T3394 | Timosaponin BII | Prototimosaponin A III | Beta Amyloid , Others , BACE |
Timosaponin BII (Prototimosaponin A III) has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-regulation of BACE1 and reduced the... | |||
T3S1265 | Liriopesides B | Nolinospiroside F | Others |
Liriopesides B (Nolinospiroside F) exhibited potential anticancer activity against human ovarian cancer A2780 cells. | |||
TN1039 | Tamarixetin | 4'-O-Methyl Quercetin | Endogenous Metabolite , Immunology/Inflammation related |
Tamarixetin (4'-O-Methyl Quercetin) (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin, with anti-inflammatory and anti-oxidative effects. Tamarixetin protects against cardiac hypertrophy. | |||
TN2244 | Sulfuretin | NF-κB , Autophagy | |
Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr... | |||
T5669 | Citric acid monohydrate | Others | |
Citric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients a... | |||
T5S0636 | Citric acid | Citro,Citretten | Apoptosis , Others , Endogenous Metabolite , Antibacterial , Antibiotic |
1. Citric acid (Citro) (1-2 g/kg) can decrease brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. 2. Citric acid denture cleansers can reduce C. albicans biofilm accumulation and cell viabili... | |||
TN1926 | Methyl caffeate | Methyl caffeate acid | Others , Antibacterial |
Methyl caffeate (Methyl caffeate acid) acid | |||
T2800 | L-Theanine | Apoptosis , Others | |
L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis and is known to promote relaxation without sedation. | |||
T10148 | 4-Hydroxynonenal | 4-HNE | Dehydrogenase , Endogenous Metabolite |
4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). | |||
T3S1319 | (+)-Magnoflorine | Escholin,Magnoflorine,Thalictrin,Escholine | Others , Antifungal |
(+)-Magnoflorine (Thalictrin) has sedative and anxiolytic effects, probably mediated by Magnoflorine through a GABAergic mechanism of action. Magnoflorine and Sinomenine have protective effects, are mediated by some mech... | |||
TJO2742 | DL-Methionine | methionine,Acimetion,Racemethionine | Parasite |
DL-Methionine (Acimetion) is an amino acid. Amino acids are the building blocks that our bodies use to make proteins. DL-Methionine is found in meat, fish, and dairy products. It plays an important role in the many funct... | |||
T2230 | Paeoniflorin | Peoniflorin | HSP , COX |
Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall. | |||
T6220 | Nicotinamide riboside chloride | Sirtuin , Endogenous Metabolite | |
Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. | |||
T0626 | Uric Acid | 2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate | Reactive Oxygen Species , Endogenous Metabolite , Phosphorylase |
Uric Acid (Lithic acid) is an oxidation product of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE ... | |||
T20793 | Magnesium Lithospermate B | Monomethyl lithospermate B,Lithospermate B | Others |
Magnesium Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from is... | |||
T2198 | Arecoline hydrobromide | Arecoline HBr,Arecoline bromide | AChR |
Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist. | |||
T7917 | 4'-Hydroxychalcone | 2-Benzal-4-Hydroxyacetophenone | Proteasome |
4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity | |||
TN6339 | (R)-5-Hydroxy-1,7-diphenylheptan-3-one | (5R)-Dihydroyashabushiketol | Others |
(R)-5-Hydroxy-1,7-diphenylheptan-3-one ((5R)-Dihydroyashabushiketol) is extracted from the rhizomes of Alpinia officinarum, a Chinese medicinal herb. (R)-5-Hydroxy-1,7-diphenylheptan-3-one inhibits melanogenesis in theop... | |||
T3S1068 | Oxyresveratrol | trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,Tetrahydroxystilbene | Tyrosinase , Autophagy , HSV |
1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxid... | |||
T3982 | Vulpinic Acid | Vulpic acid,Pulvinic acid methyl ester | Others |
Vulpinic Acid (Pulvinic acid methyl ester) is a lichen metabolite with anti-inflammatory, antibacteria, properties, plant growth inhibitor. | |||
T3S1320 | (+)-Magnoflorine iodide | Magnoflorine iodide,Thalictrine iodide,Corytuberine Methiodide | Others , Antifungal |
(+)-Magnoflorine iodide (Thalictrine iodide) has anti-inflammatory activity, it can inhibit inflammations. | |||
T6S0117 | Avicularin | Fenicularin | ERK |
Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX... | |||
T4S1321 | (+)-Magnoflorine chloride | Magnoflorine chloride,Corytuberine methochloride,Thalictrine chloride,Escholine chloride | Others , Antifungal |
(+)-Magnoflorine chloride (Escholine chloride) has anti-inflammatory activity, it can inhibit inflammations. | |||
T8193 | α-Thujone | Thujone,ALPHA-(-)-THUJONE | Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy |
α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM. | |||
T2870 | Matrine | Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine | Mitophagy , Ferroptosis , Opioid Receptor , Autophagy |
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist. | |||
T9454 | 4-Hydroxyestrone | Estrogen Receptor/ERR , Endogenous Metabolite | |
4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage. | |||
T37710 | 5-Hydroxyoxindole | Reactive Oxygen Species | |
5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria [1]. 5-Hydroxyoxindole has lipid peroxidation inhibition activit... | |||
TN6909 | Polyporusterone B | (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one | Others |
Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) is a triterpene carboxylic aci... | |||
T20597 | Alginic acid | Protanal LF,Snow acid algin G,Kelacid,Sazzio,Norgine | Apoptosis , Autophagy , Histamine Receptor |
Alginic acid (Snow acid algin G) is a natural polysaccharide extracted from brown seaweeds with anti-anaphylactic and anti-inflammatory activities. Alginic acid inhibits histamine release and can be used in the food indu... | |||
TN6924 | Anhydrosafflor yellow B | (2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,AHSYB | Others |
Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,... | |||
TN1461 | (-)-Butin | Butin | Akt , PI3K , Nrf2 |
(-)-Butin (Butin) has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates oxidative stress by activating Nrf2-mediated Mn SO... | |||
T2S2003 | Phlorizin dihydrate | Phloridzin dihydrate | Others |
1. Phlorizin dihydrate (Phloridzin dihydrate) can significantly inhibit oxidative DNA damage. | |||
T8177 | Galactinol | Others | |
Galactinol Hydrate scavenges hydroxyl free radicals and protects plant cells from oxidative damage. | |||
T6S1966 | Curculigoside | Curculigoside A | Antioxidant , NF-κB , JAK , STAT |
1. Curculigoside (Curculigoside A) can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disord... | |||
T2S2172 | Nerolidol | (±)-Nerolidol,Peruviol | Others , Endogenous Metabolite , Antibacterial , Parasite , Antifungal |
Nerolidol (Peruviol) shows sedative effects in animals, oxidative process plays a crucial role on neuronal pathological consequence. Nerolidol is mainly related to ROS and DNA single strand breaks generated by the presen... | |||
TN1600 | Eclalbasaponin I | Others | |
Eclalbasaponin I has anti-oxidative, and antitumor activities, it reduces oxidative stress-induced neural cell death by autophagy activation, it can dose-dependently inhibit the proliferation of hepatoma cell smmc-7721 w... | |||
T19165 | 8-Hydroxyguanine | 8 Hydroxyguanine,7,8-dihydro-8-oxoguanine,2-Amino-6,8-dihydroxypurine | Endogenous Metabolite |
8-Hydroxyguanine (8 Hydroxyguanine) is the major premutagenic damage produced by reactive oxygen species. It causes G-T and A-C substitutions.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage.8-H... | |||
T8704 | 4-hydroxyphenyl acetate | Nrf2 | |
4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer | |||
T6S1768 | Narcissin | Isorhamnetin 3-Rutinoside,Narcissoside | Antioxidant |
Narcissin (Isorhamnetin 3-Rutinoside), with synergism of B.flavum flavonoid and rutin, could be responsible for stronger protection against mitochondrial induced oxidative stress. | |||
T2805 | Chlorogenic Acid | NSC-407296,3-O-Caffeoylquinic acid,Heriguard | Others , Influenza Virus , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Antibacterial |
Chlorogenic Acid (NSC-407296) is a naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. | |||
T2S1008 | Oxysophoridine | Sophoridine N-oxide | Apoptosis , Antioxidant |
Oxysophoridine (Sophoridine N-oxide) has a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms; it may be a potential neuroprotective agent for cerebral ischemia injury, ... | |||
------------------------ More ------------------------ |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04460 | OXSR1 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environme... | |||
TMPH-00359 | AlkB Protein, Caulobacter vibrioides, Recombinant (His & Myc) | Caulobacter vibrioides | E. coli |
Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing... | |||
TMPH-00577 | AlkB Protein, E. coli, Recombinant (His & Myc & SUMO) | E. coli | E. coli |
Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing... | |||
TMPY-00541 | LON PROTEASE Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Lon protease, an ATP-dependent mitochondrial protease, is important in mitochondrial protein maintenance. Lon protease is a multifunctional enzyme, and its functions include the degradation of damaged proteins and natura... | |||
TMPY-01403 | VNN1 Protein, Human, Recombinant (His) | Human | HEK293 |
Pantetheinase, also known as Pantetheine hydrolase, Vascular non-inflammatory molecule 1, Vanin-1, and VNN1, is a cell membrane protein which belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 contains one... | |||
TMPH-02681 | GPX7 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. | |||
TMPH-01397 | LANCL1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during norma... | |||
TMPH-00641 | YTFE Protein, E. coli, Recombinant (GST) | E. coli | E. coli |
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions. | |||
TMPY-02299 | ALDH3A1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (... | |||
TMPH-03443 | GPX2 Protein, S. cerevisiae, Recombinant (His & Myc) | Saccharomyces cerevisiae | E. coli |
Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress. Plays an important role in the oxidative stress-induced response in the pres... | |||
TMPH-03275 | Cytoglobin Protein, Rat, Recombinant (His & Myc) | Rat | E. coli |
May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer. Plays a role in the development of liver fibrosis. Has a peroxidase activity. | |||
TMPY-02043 | PARK7/DJ-1 Protein, Human, Recombinant (His) | Human | E. coli |
Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress.... | |||
TMPH-02863 | LOX Protein, Mouse, Recombinant (His & Myc) | Mouse | Baculovirus |
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in t... | |||
TMPH-01553 | GBP2 Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to aut... | |||
TMPH-01296 | GPX5 Protein, Human, Recombinant (GST & His) | Human | E. coli |
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective syste... | |||
TMPH-00773 | RuBisCO large subunit Protein, Glycine max, Recombinant (His & SUMO) | Glycine max | E. coli |
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration pro... | |||
TMPK-00077 | EPO/Erythropoietin Protein, Human, Recombinant | Human | HEK293 |
Erythropoietin (EPO) is a circulating hormone conventionally considered to be responsible for erythropoiesis. In addition to facilitating red blood cell production, EPO has pluripotent potential, such as for cognition im... | |||
TMPH-03054 | Asp f3 Protein, Neosartorya fumigata, Recombinant (His & SUMO) | Neosartorya fumigata | E. coli |
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxide... | |||
TMPH-02903 | PON1 Protein, Mouse, Recombinant | Mouse | E. coli |
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediate... | |||
TMPY-00089 | TMIGD1 Protein, Human, Recombinant (His) | Human | HEK293 |
The transmembrane and immunoglobulin domain-containing 1 (TMIGD1) is a novel tumor suppressor that is highly expressed in normal renal tubular epithelial cells, but it is downregulated in human renal cancer. TMIGD1 is a ... | |||
TMPY-04073 | MRPL44 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
MRPL44 (Mitochondrial Ribosomal Protein L44) is a Protein Coding gene. MRPL44 encodes a protein in the large subunit of the mitochondrial ribosome and is suggested to locate near the tunnel exit of the yeast mitochondria... | |||
TMPH-00794 | Dps Protein, Helicobacter pylori, Recombinant (His & SUMO) | Helicobacter pylori | E. coli |
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical produ... | |||
TMPY-04872 | TMIGD1 Protein, Human, Recombinant (mFc) | Human | HEK293 |
The transmembrane and immunoglobulin domain-containing 1 (TMIGD1) is a novel tumor suppressor that is highly expressed in normal renal tubular epithelial cells, but it is downregulated in human renal cancer. TMIGD1 is a ... | |||
TMPH-00072 | 2-Cys Prx A Protein, Arabidopsis thaliana, Recombinant (His) | Arabidopsis thaliana | Yeast |
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxide... | |||
TMPH-03721 | IbpA Protein, Yersinia pestis bv. Antiqua, Recombinant (His) | Yersinia pestis | E. coli |
Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the Ibp... | |||
TMPH-02199 | TXNRD2 Protein, Human, Recombinant (His) | Human | E. coli |
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxide... | |||
TMPH-02102 | PON1 Protein, Human, Recombinant (GST) | Human | E. coli |
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediate... | |||
TMPH-02875 | ROMO1 Protein, Mouse, Recombinant (His) | Mouse | in vitro E. coli expression system |
Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.; Induces production of reactive oxygen species (ROS) which are n... | |||
TMPH-02153 | Sulfiredoxin-1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduct... | |||
TMPJ-01248 | Cytoglobin/CYGB Protein, Human, Recombinant (His) | Human | E. coli |
Cytoglobin is a ubiquitously globin protein that belongs to the globin family. The highest expressed in heart, stomach, bladder and small intestine. CYGB acts a protector under conditions of oxidative stress. CYGB may be... | |||
TMPH-00093 | GAPC1, cytosolic Protein, Arabidopsis thaliana, Recombinant (His & Myc) | Arabidopsis thaliana | E. coli |
Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carboh... | |||
TMPJ-00982 | DHS Protein, Human, Recombinant (His) | Human | E. coli |
Human Deoxyhypusine Synthase (DHS) is vital for the first step of hypusine biosynthesis. DHS catalyzes the NAD-dependent oxidative cleavage of spermidine, the subsequent transfer of the butylamine moiety of spermidine to... | |||
TMPH-02104 | Sestrin-3/SESN3 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may al... | |||
TMPJ-00380 | AOC3 Protein, Human, Recombinant (His) | Human | Human Cells |
Vascular adhesion protein-1(VAP-1) is a copper amine oxidase with a topaquinone cofactor.VAP-1 is a type II integral membrane protein, but a soluble form of the enzyme is present in human serum, and its level increases i... | |||
TMPJ-00720 | TXNDC12 Protein, Human, Recombinant (His) | Human | Human Cells |
Thioredoxin Domain-Containing Protein 12 belongs to the thioredoxin superfamily. In this family, proteins possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defens... | |||
TMPH-03460 | ERG26 Protein, S. cerevisiae, Recombinant (His & Myc) | SVG-Saccharomyces cerevisiae | E. coli |
Essential enzyme in the ergosterol biosynthetic pathway. Part of a 3 enzyme system that catalyzes the sequential removal of the 2 methyl groups at the sterol C-4 position, converting 4,4-dimethylzymosterol to zymosterol.... | |||
TMPJ-01076 | FKBP4 Protein, Human, Recombinant (His) | Human | E. coli |
FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone recepto... | |||
TMPH-02618 | CYP2E1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electr... | |||
TMPH-02997 | Dps Protein, Mycobacterium smegmatis, Recombinant (His & SUMO) | Mycobacterium smegmatis | E. coli |
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical produ... | |||
TMPK-00285 | ANGPTL3 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
ANGPTL3 is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C‑terminal fibrinogen-like domain. ANGPTL3 is expressed in the li... | |||
TMPY-02544 | FANCA Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
FANCA is one of the six known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins). Fanconi anemia (FA) is a genetic disorder predisposing to aplastic anemia and cancer characterized by h... | |||
TMPY-01770 | HAO1 Protein, Human, Recombinant (His) | Human | E. coli |
Hydroxyacid oxidase 1, also known as Glycolate oxidase, HAO1, and GOX1, is a member of the FMN-dependent alpha-hydroxy acid dehydrogenase family. HAO1 / GOX1 has 2-hydroxyacid oxidase activity. It is most active on the 2... | |||
TMPY-02201 | Peroxiredoxin 6 Protein, Human, Recombinant (His) | Human | E. coli |
PRDX6, a member of antioxidant protein superfamily, plays an important role in oxidative stress, catabolism of lipids and phospholipid lipisomes. Peroxiredoxin 6 (PRDX6) is involved in redox regulation of the cell and is... | |||
TMPH-02687 | Granzyme A/GZMA Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or ... | |||
TMPH-01761 | Neuroglobin Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhi... | |||
TMPJ-00379 | AOC3 Protein, Human, Recombinant (hFc) | Human | Human Cells |
Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycop... | |||
TMPY-02401 | Tyrosine Hydroxylase Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Tyrosine hydroxylase (TH) is a rate-limiting enzyme in catecholamine synthesis. Tyrosine hydroxylase activity is modulated by protein-protein interactions with enzymes in the same pathway or the tetrahydrobiopterin pathw... | |||
TMPY-02587 | Tyrosine Hydroxylase Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Tyrosine hydroxylase (TH) is a rate-limiting enzyme in catecholamine synthesis. Tyrosine hydroxylase activity is modulated by protein-protein interactions with enzymes in the same pathway or the tetrahydrobiopterin pathw... | |||
TMPY-02271 | TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His) | Human | E. coli |
Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidat... | |||
TMPH-02661 | Frataxin/FXN Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress thr... | |||
------------------------ More ------------------------ |
Cat No. | Product Name | ||
---|---|---|---|
L2910 | Antioxidant Compound Library | 1330 compounds | |
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species (ROS) and a biological system's ability to readily detoxify the reactive intermediates or repair the resulting damage. ... | |||
L5300 | Mitochondria-Targeted Compound Library | 830 compounds | |
A unique collection of 830 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine; | |||
L6110 | Alkaloid Natural Product Library | 468 compounds | |
A unique collection of 468 natural alkaloids can be used for high throughput and high content screening; | |||
L6140 | Saccharide and Glycoside Natural Product Library | 364 compounds | |
A unique collection of 364 saccharides and glycosides compounds can be used for HTS and HCS; | |||
L2520 | Glycometabolism Compound Library | 708 compounds | |
708 glycometabolism-related comounds, can be used for HTS and HCT; | |||
L6120 | Flavonoid Natural Product Library | 477 compounds | |
A unique collection of 477 flavonoids can be used for high throughput and high content screening; | |||
L9840 | Anti-Alzheimer's Disease Compound Library | 1040 compounds | |
A unique collection of 1040 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS. |