MIF

MIF (Macrophage Migration Inhibitory Factor) is a multifunctional cytokine expressed in diverse cell types, including macrophages, T cells, and endothelial cells. By binding to receptors such as CD74 and CD44, MIF activates multiple signalling pathways involved in regulating immune responses, inflammation, and cell proliferation. MIF plays a significant role in various diseases, such as inflammatory conditions, autoimmune disorders, and cancer. During inflammatory responses, MIF promotes the secretion of inflammatory mediators by suppressing the anti-inflammatory effects of glucocorticoids. In cancer, MIF contributes to tumour initiation and progression by promoting the proliferation and migration of tumour cells.