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Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

MIF

MIF (Macrophage Migration Inhibitory Factor) is a multifunctional cytokine expressed in diverse cell types, including macrophages, T cells, and endothelial cells. By binding to receptors such as CD74 and CD44, MIF activates multiple signalling pathways involved in regulating immune responses, inflammation, and cell proliferation. MIF plays a significant role in various diseases, such as inflammatory conditions, autoimmune disorders, and cancer. During inflammatory responses, MIF promotes the secretion of inflammatory mediators by suppressing the anti-inflammatory effects of glucocorticoids. In cancer, MIF contributes to tumour initiation and progression by promoting the proliferation and migration of tumour cells.

Filter HomeSignaling PathwaysImmunology/InflammationMIF

ISO-1

T3680478336-92-4

ISO-1 (MIF Antagonist) is an inhibitor of the dopachrome tautomerase activity, blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages.

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Cited

Carebastine

T1068090729-42-3

Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor.

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4-IPP

T784441270-96-6

4-IPP (4-Iodo-6-phenylpyrimidine) is an irreversible inhibitor of macrophage migration inhibitory factor (MIF).

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4-CPPC

T3829329553-70-6

4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50= 27 μM).1It is selective for MIF-2 over MIF-1 (IC50= 450 μM). It inhibits MIF-2, but not MIF-1, binding to CD74in vitrowhen used at a concentration of 10 μM. 4-CPPC (5, 10, and 25 μM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts. 1.Tilstam, P.V., Pantouris, G., Corman, M., et al.A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activityJ. Biol. Chem.294(49)18522-18531(2019)

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BTZO-1

T784599420-15-2

BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.

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(±)-CPSI-1306

T173151309793-47-2

(±)-CPSI-1306 (2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one) is a macrophage migration inhibitory factor (MIF) antagonist and can be used in studies about non-insulin-dependent diabetes mellitus (NIDDM) and the prevention of the deleterious cutaneous effects of acute and chronic UVB exposure.

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Iguratimod

T5032123663-49-0

Iguratimod (T614) is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.

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RDR03785

T9981289657-30-3

The MIF Antagonist IV, RDR 03785 controls the biological activity of MIF. This small molecule inhibitor is primarily used for Cell Structure applications.

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3-Cyano-7-hydroxycoumarin

T7767419088-73-4

3-Cyano-7-hydroxycoumarin (3-Cyanoumbelliferone) is a macrophage inhibitor of macrophage inhibitory factor (MIF) interconjugate isomerase with a Ki of 2.9 μM. 3-Cyano-7-hydroxycoumarin belongs to the group of coumarin derivatives, which can be used as molecular probes and fluorescent dyes.

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MIF098

T603881208448-95-6

MIF098, a macrophage migration inhibitory factor (MIF) antagonist, inhibits pulmonary hypertension associated with SLE and the proliferation and migration of pulmonary arterial smooth muscle cells (PASMC). MIF098 may also be used to study idiopathic pulmonary hypertension.

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MIF-IN-2

T608502756410-57-6In house

MIF-IN-2 is a heterocyclic macrophage migration inhibitory factor (MIF) inhibitor with anticancer activity for the study of cancer and autoimmune disorders.13460-73-86-5

$176

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Mitomycin A

T367054055-39-4

Mitomycin A is a cytotoxic antibiotic derived from Streptomyces sp. with anticancer activity and antitumor activity.Mitomycin A is used in the study of solid cancers.

$170

35 days

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MD13

T41225 In house

MD13 is a macrophage migration inhibitor (MIF) oriented PROTAC (Ki value: 71 nM). MD13 can be used to study cancer.

$1,520

6-8 weeks

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R110

T607441985622-33-0

R110 shows the potential for cancer research that is a potent, competitive MIF2 tautomerase inhibitor (IC 50 = 15 μM) [1].

$1,170

6-8 weeks

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MIF-IN-1

T60809851095-20-0

MIF-IN-1 (compound 14) is a potent inhibitor of macrophage migration inhibitory factor (MIF) with a pIC50 of 6.87, targeting a proinflammatory cytokine linked to various diseases, including neurodegenerative disorders [1].

$1,520

6-8 weeks

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MIF-IN-5

T612182582755-31-3

MIF-IN-5 (compound 1d) is a potent, reversible competitive inhibitor of macrophage migration inhibitory factor (MIF), with an IC₅₀ of 4.8 μM and a Ki of 3.3 μM [1].

$1,520

6-8 weeks

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MIF-IN-6

T617052582758-61-8

MIF-IN-6 (compound 2d) is an effective inhibitor of macrophage migration inhibitory factor (MIF), with an IC50 of 1.4 μM and a Ki value of 0.96 μM. It effectively reduces MIF-induced ERK phosphorylation and impedes A549 cell proliferation [1].

$1,520

6-8 weeks

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Spirohexenolide A

T895261193347-22-6

Spirohexenolide A is an inhibitor of human macrophage migration inhibitory factor (hMIF) with a dissociation constant (Kd) of 35.9 μM. It is employed in the study of cellular transport.

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TE-11

T207303160488-11-9

TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.

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10-14 weeks

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MKA031

T787162951012-00-1

MKA031 (compound 6y) is a non-competitive inhibitor of macrophage migration inhibitory factor (MIF) with an IC50 of 1.7 μM. It disrupts the MIF-aryl hydrocarbon receptor interacting protein (AIF) interaction, impedes MIF nuclear translocation, and mitigates N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced cell death. MKA031 is applicable in research on chronic hepatitis C virus infection [1].

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8-10 weeks

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MIF-IN-3

T623442756410-83-8

MIF-IN-3 is an inhibitor of migration inhibitory factor (MIF), which can be used in the study of immunoinflammation-related diseases.

$1,520

6-8 weeks

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MIF-IN-4 hydrochloride

T633222489514-05-6

MIF-IN-4 hydrochloride is a potent inhibitor of macrophage mobility inhibitory factor (MIF) with pIC50 values ranging from 5.01-6. Where MIF was originally discovered as a cytokine in the process of inhibiting macrophage migration.

$1,520

6-8 weeks

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Imalumab

T767891430205-07-4

Imalumab (BAX69), a recombinant human IgG1 monoclonal antibody, specifically targets macrophage inhibitory factor (MIF). It is utilized in the research of ovarian carcinoma, recurrent malignant ascites, and cancer [1].

$439

2-4 weeks

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MIF degrader MD13

T695252758431-97-7

MIF degrader MD13 is involved in protein-protein interactions that play key roles in inflammation and cancer. Current strategies to develop small molecule modulators of MIF functions are mainly restricted to the MIF tautomerase active siteMIF degrader MD13. MD13 also exhibits antiproliferative effect in a 3D tumor spheroid model. In conclusion, we describe the first MIF-directed PROTAC (MD13) as a research tool, which also demonstrates the potential of PROTACs in cancer therapy.

$1,420

35 days

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