s-4

Andarine (GTx-007) (S-4) is an active partial agonist and an investigational selective androgen receptor modulator (SARM).

CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.

Franganine is a 14-membered-ring cyclopeptide analgesic alkaloid.

RhlR agonist S4 is a quorum sensing modulator as an RhlR agonist.

Apratoxin S4 (Apra S4), a potent inhibitor of Sec61, disrupts the cotranslational translocation of secretory proteins into the endoplasmic reticulum (ER), showcasing antiviral efficacy against select flaviviruses with IC 50 values spanning 0.46 nM to 170 nM. It also curtails retinal vascular cell activation by targeting various angiogenic pathways. This compound is valuable for investigating viral infections, angiogenic diseases, and cancers [1] [2].

Dermaseptin-S4, an antimicrobial peptide sourced from frog skin, exhibits efficacy against filamentous fungi [1].

Maximin S4, an antimicrobial peptide sourced from the toad Bombina maxima, exhibits antibacterial activity against mycoplasma [1].

MS-444 (BE-34776) is a smooth muscle myosin light chain kinase (MLCK) and HuR inhibitor with antitumor activity for triple-negative breast and colorectal cancer.

BMS-488043 is a novel and unique oral small molecule HIV fusion inhibitor that inhibits the attachment of Human Immunodeficiency Virus type 1 (HIV-1) to CD4(+) lymphocytes.BMS-488043 is used for the treatment of immune disorders, infections, and genitourinary disorders, and can be used in the study of HIV infect

GS-443902 trisodium (GS-441524 triphosphate trisodium), the active triphosphate metabolite of Remdesivir (GS-5734), serves as a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp), displaying inhibitory concentrations (IC50) of 1.1 μM for RSV RdRp and 5 μM for HCV RdRp.

cis-L-Hydroxyproline inhibits the synthesis and extracellular deposition of collagen. The growth inhibition of pancreatic cancer cells induced by the Hyp isomer could be due to endoplasmatic reticulum stress.

2-Ethylhexyl trans-4-methoxycinnamate is a sunscreen agent.

cis-4-Amino-1-Boc-3-methoxy-piperidine ,with CAS No. 1171124-68-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. cis-4-Amino-1-Boc-3-methoxy-piperidine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

trans-4-(methylamino)tetrahydrothiophene-3-ol 1,1-dioxide ,with CAS No. 1212106-05-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. trans-4-(methylamino)tetrahydrothiophene-3-ol 1,1-dioxide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

rac-trans-4-hydroxy Glyburide, an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide, is formed by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. It inhibits glyburide binding to rat brain synaptosomes at high and low affinity sites of SUR1/Kir6.2 with IC50 values of 0.95 and 100 nM, respectively.

S-4-Nitrobutyryl-CoA (4-Nitrobutyryl-coenzyme A) is a derivative of coenzyme A.

BMS-470539 dihydrochloride is a selective and highly potent melanocortin 1 receptor (MC-1 R) agonist with anti-inflammatory activity. BMS-470539 attenuates oxidative stress and neuronal apoptosis via the MC1R/cAMP/PKA/Nurr1 signaling pathway in a neonatal hypoxia-ischemia rat model.

YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).

YS-49 (monohydrate) is an activator of PI3K/Akt (a downstream target of RhoA).

DS-437 is a dual PRMT5/7 inhibitor with IC50 values of 6 μM and also inhibits DNMT3A and DNMT3B with IC50 values of 52 μM and 62 μM, respectively. Additionally, DS-437 inhibits the methylation of FOXP3.

JQ dS-4 is a degrader of Brahma-related gene 1 (BRG1)/BRM/SMARCA4 (PROTAC®; DC50 range = 9 - 390 nM in glioma models and cell lines), featuring a BRG1 inhibitor connected through a linker to a cereblon (CRBN) E3 ligase ligand. It effectively degrades BRG1 completely over 48 and 72 hours in HSJD-DIPG007 and SU-DIPGXIIIP cells. Additionally, it lessens the viability of various cancer cell lines, including those of H3K27M glioma, prostate, thyroid, and salivary gland.

Cis-4-Heptenal is an aldehyde commonly used in flavor preparation, organic synthesis and biochemical experiments.

WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 μM, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC).

trans-4-Hydroxycrotonic acid (T-HCA) is a highly selective and competitive ligand for the γ-hydroxybutyric acid (GHB) binding site, with a Ki value of 1.1 μM for [3H]NCS-382, and can be used to study three-dimensional pharmacophore models.