5a,6a-epoxy cholestanol

Cholesterol-5α,6α-epoxide (Epoxycholesterol) is the metabolite of cholesterol produced by oxidation. Cholesterol-5α,6α-epoxide induces triacylglycerol biosynthesis by binding to LXRβ following tamoxifen and PBPE application.

Lysophosphatidylcholines (Lyso-Lecithins (egg)) are orally active lipids that induce cell damage and apoptosis, and induce demyelination. Lysophosphatidylcholines play a role in mediating inflammation, fibrosis, and cancer, and can be used to study atherosclerosis.

Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4 1.Lopez, J.A.V., Nogawa, T., Futamura, Y., et al.Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647J. Antibiot. (Tokyo)72(12)991-995(2019) 2.Ishida, S., Arai, M., Niikawa, H., et al.Inhibitory effect of cyclic trihydroxamate siderophore, desferrioxamine E, on the biofilm formation of Mycobacterium speciesBiol. Pharm. Bull.34(6)917-920(2011) 3.Kalinovskaya, N.I., Romaneko, L.A., Irisawa, T., et al.Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activityMicrobiol. Res.166(8)654-661(2011) 4.Matsubara, K., Sakuda, S., Tanaka, M., et al.Morphological changes in insect BM-N4 cells induced by nocardamineBiosci. Biotechnol. Biochem.62(10)2049-2051(1998)

Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1 EDG-1, S1P2 EDG-5, S1P3 EDG-3, S1P4 EDG-6, and S1P5 EDG-8. W140 is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 μM (2a = W146; 2b = W140 in supplemental material). It exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146.

Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate known for activating the adenosine 5'-triphosphate-sensitive K+ channel, serving as a potential iron mobilizer by inhibiting the hepcidin-ferroportin interaction, and modulating the interleukin-6 (IL-6) stat-3 pathway. It is utilized in research on inflammation-related conditions, including anemia of inflammation (AI).

LNP Lipid-6 is an ionizable lipid (amino lipid) that is utilized in the preparation of lipid nanoparticles (LNP).

Polyacrylamide, Nonionic, Mw 5-6 million (Acrylamide polymer, Nonionic, Mw 5-6 million), is a versatile polymer known for its moisturizing properties. This compound can be utilized as a biomaterial or organic compound in life science research.

5-Bromo-2,4-diamino-6-hydroxypyrimidine is a biochemical reagent.

5-Bromo-6-chloro-3-indolyl-β-D-glucopyranoside has potential applications in glycobiology research.

5-Bromo-6-chloro-3-indolyl-N-acetyl-β-D-glucosaminide, 98%, is a chromogenic substrate utilized to assess β-galactosidase activity in foods, enzyme substrates, and culture media.

5-Bromo-6-chloro-3-indolyl a-D-glucopyranoside is a biochemical reagent used in glycobiology research. Glycobiology focuses on the study of the structure, synthesis, biology, and evolution of sugars, encompassing carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan interactions, and the roles of glycans in biological systems. This field is closely linked to fundamental research, biomedicine, and biotechnology.

5-Bromo-6-chloro-1H-indol-3-yl α-D-galactopyranoside has potential applications in glycobiology research.

Benzyl 2,3-O-Isopropylidene-6-O-trityl-5-keto-α-D-mannofuranose is a biochemical reagent used in glycobiology research. Glycobiology explores the structure, synthesis, biology, and evolution of sugars, encompassing carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. This field is closely linked to fundamental research, biomedicine, and biotechnology.

5-Azido-6-(tert-butyldimethylsilyl)-2,3-O-isopropylidene L-gulono-1,4-lactone is a biochemical reagent used in glycoscience research. This field investigates the structure, synthesis, biology, and evolution of sugars, covering carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan interactions, and glycans' roles in biological systems. Glycoscience is closely linked to fundamental research, biomedicine, and biotechnology.

Benzyl 5-amino-5-deoxy-2,3-O-isopropylidene-6-O-trityl-α-D-mannofuranoside is a biochemical reagent utilized in glycobiology research. Glycobiology focuses on the study of carbohydrates, including their structure, synthesis, biology, and evolution. This field encompasses carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan interactions, and the roles of glycans within biological systems. It is closely linked to fundamental research, biomedicine, and biotechnology.

5-Thio-D-glucose-6-phosphate diammonium salt is a biochemical reagent used in glycoscience research. Glycoscience investigates sugar structure, synthesis, biology, and evolution. It encompasses carbohydrate chemistry, glycan creation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely linked to fundamental research, biomedicine, and biotechnology.

5-Bromo-6-chloro-3-indolyl phosphate p-toluidine (Magenta phosphate) is employed to visualize alkaline phosphatase activity by generating an insoluble magenta-colored end product. When combined with nitro blue tetrazolium, it allows for the visual assessment of results.

ST3 beta-Gal alpha-2,3-Sialyltransferase 6 (EC:2.4.99., ST3GAL6; SIAT10, Type 2 lactosamine alpha-2,3-sialyltransferase) is responsible for transferring sialic acid from activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to N- or O-linked glycans on glycoproteins. This enzyme plays a significant role in cancer.

Carbohydrate Sulfotransferase 5 (EC:2.8.2.-) catalyzes the transfer of sulfate groups to non-GlcNAc residues of mucin-type receptors and the 6-position of O-linked sugars.

5-Bromo-6-chloronicotinic acid is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

5-Bromo-6-chloro-1H-indol-3-yl acetate is a member of the indole compound family and a derivative of the aromatic heterocyclic compound indole. It has been utilized in various research settings, including studies on enzyme kinetics and protein-ligand interactions. This compound serves as a biomaterial or organic compound applicable to life science research.