insect

Picaridin (Lcaridin) is a topical insect repellent.

Epinastine hydrochloride (WAL-801CL HCl) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.

Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.

Methoprene (ZR-515) is a juvenile hormone (JH) mimic and a biological pesticide. Methoprene acts as an insect growth regulator interfering with the lifecycles of insects and preventing insects from reaching maturity or reproducing.

Insect repellent M 3535 is a bug repellant.

Stick Insect Hypertrehalosaemic Factor II, a synthetic peptide, exhibits identical FAB spectra, reversed-phase high-performance liquid chromatographic profiles (behavior), and biological activity (behavior) as its natural counterpart and is utilized in researching the hypertrehalosaemic effect [1].

Insect repellent M 3535 (Standard) is the standard substance of Insect repellent M 3535, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Insect repellent M 3535 is a bug repellant.

Triflumuron is an insecticide belonging to the group of so-called insect growth regulators. It inhibits the synthesis of chitin by the insect larvae, causing the die.

Isoasatone A, a natural product isolated from the plant [Heterotropa takaoi M.], exhibits anti-insect activity.

Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein. Insecticidal agent 364 has antitumor activity, and by inhibiting mTOR, Insecticidal agent 364 aims to disrupt signaling pathways involved in cancer cell growth and survival, thereby potentially inhibiting tumor growth.

Insecticidal agent 25 (Compound WZ18) targets nicotinic acetylcholine receptors (nAChRs) in the insect nervous system. It disrupts neural transmission by competitively binding to nAChRs, resulting in paralysis and death of the insects.

Insecticidal Agent 3, a multichitinase inhibitor and part of the insect growth regulators (IGRs) group, exhibits strong inhibition with Ki values of 0.8 μM, 11.9 μM, and 2.3 μM against Of ChtI, Of ChtII, and Of Chi-h enzymes, respectively. It demonstrates effective insecticidal activity against two lepidopteran pests by disrupting insect growth and molting processes [1].

Insecticidal Agent 7 (Compound 21m) is an insecticide that acts on insect ryanodine receptors (RyRs), exhibiting a potency with a LC 50 of 0.0937 mg/L against Plutella xylostella. It demonstrates significant selectivity and minimal toxicity toward non-target organisms [1].

Insecticidal agent 16 (compound A21) exhibits insecticidal activity against Plutella xylostella, with LC50 values of 1.2 and 13.2 µg/mL respectively.

Insecticidal agent 18 (compound 34) is an effective insecticide. It exhibits acaricidal activity.

Insecticidal agent 17 (compound 31) is a pesticide with an LC50 value of 0.759 mg/mL against the diamondback moth.

Insecticidal agent 19 (Compound 7b) exhibits antimalarial activity by inhibiting dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) through the folate metabolic pathway. This compound also inhibits the promastigote and amastigote forms of Leishmania major, with IC50 values of 1.43 μM and 3.78 μM, respectively.

Insecticidal agent 20 (Compound 17) is an insecticide that binds to AChBP. It demonstrates effective insecticidal activity against mosquito larvae (LC50: 1.57 ppm) and pupae (LC50: 4.17 ppm).

Insecticidal agent 21 (Compound 6) is an insecticide targeting Culex pipiens larvae with an LC50 of 0.4 μg/mL. It achieves multi-target neurotoxicity by inhibiting acetylcholinesterase (AChE) and simultaneously targeting other neural receptors, including nicotinic acetylcholine receptors (nAChR), voltage-gated sodium channels (VGSC), and γ-aminobutyric acid receptors (GABAAR). Insecticidal agent 21 shows potent insecticidal activity and can be utilized in the development of new insecticides to combat mosquito resistance to conventional agents.

Insecticidal agent 22 (Compound A13) is an insecticide with LC50 values of 1.4 and 9.9 μg/mL against Plutella xylostella and Spodoptera frugiperda, respectively. It serves as a low-toxicity alternative to Fluralaner.

Insecticidal agent 24 is an orally active pyridinyl spiroindoline lead compound. It demonstrates antimalarial activity with Pf NF54IC50 of 0.08 μM. Insecticidal agent 24 also inhibits hERG activity with an IC50 of 6.5 μM. In a humanized immunodeficient NSG mouse model of malaria infection, it effectively reduces parasitemia.

Insecticidal agent 23 (compound 17) possesses anti-schistosomal properties with low toxicity. It exhibits strong in vitro activity against adult Schistosoma japonicum, with an LC50 (72 h) value of 25.31 μM.

Insecticidal agent 5 (compound 8) is an AChE-targeting insecticide with an LD50 of 27.65 ppm against the cotton leafworm Spodoptera littoralis.

Insecticidal agent 8 is an insecticide with significant biological selectivity against the pea aphid (Aphis craccivoraKoch) and the diamondback moth (Plutella xylostella).