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Cat No. | Product Name | Synonyms | Targets |
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T63536 | Dual FAAH/sEH-IN-1 | FAAH , Epoxide Hydrolase | |
Dual FAAH/sEH-IN-1 is a dual inhibitor of sEH (soluble epoxide hydrolase) (IC50: 9.6 nM) and FAAH (fatty acid amide hydrolase) (IC50: 7 nM) with high affinity and anti-inflammatory activity. | |||
T2381 | Abemaciclib | CDK4/6 dual inhibitor,LY2835219 | CDK |
Abemaciclib (CDK4/6 dual inhibitor) is an effective and specific CDK4/6 inhibitor (IC50: 2/10 nM). | |||
T1811 | WH-4-023 | KIN112,KIN001-112,Dual LCK/SRC inhibitor | Src |
WH-4-023 (Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor. It also potently inhibits SIK. | |||
T5093 | Pim1/AKK1-IN-1 | LKB1/AAK1 dual inhibitor,MDK-2275 | Pim , Hippo pathway |
Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK. | |||
T82524 | Dual photoCORM 1 | ||
Dual photoCORM 1 (compound 5), a metal-free, photoactive, dual carbon monoxide releasing molecule (CORM), demonstrates efficient cellular uptake and enables real-time tracking of CO release via a colorimetric change in B... | |||
T74991 | Dual AChE-MAO B-IN-3 | ||
Dual AChE-MAO B-IN-3 (compound C10) is a potent dual AChE/MAO-B inhibitior, with IC 50 values of 0.58 and 0.41 μM, respectively. Dual AChE-MAO B-IN-3 is a dual-binding inhibitor bound to both the catalytic anionic site a... | |||
T62172 | Dual AChE-MAO B-IN-1 | ||
Dual AChE-MAO B-IN-1 (compound 15) is a safe, metabolically stable neuroprotective agent.Dual AChE-MAO B-IN-1 is a potent, orally active CNS-permeable inhibitor of human AChE (IC50=550 nM) and MAO-B (IC50=8.2 nM), and ha... | |||
T62152 | Dual AChE-MAO B-IN-2 | ||
Dual AChE-MAO B-IN-2 is a potent, dual inhibitor of AChE (IC50: 0.12 μM) and MAO B (IC50: 0.01 μM).Dual AChE-MAO B-IN-2 has potential for Alzheimer's disease studies. | |||
T75150 | GIP/GLP-1 dual receptor agonist-1 | ||
GIP/GLP-1 dual receptor agonist-1 (compound 4) is a GIP/GLP-1 receptor agonist. GIP/GLP-1 dual receptor agonist-1 can be used in the research of metabolic disorders and fatty liver diseases, including nonalcoholic steato... | |||
T2431 | ID-8 | ID8 | DYRK |
ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture. | |||
T6257 | AZ191 | DYRK | |
AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, respectively. | |||
T15422 | GSK-626616 | DYRK | |
GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a potential therapy for the treatment of anemia. | |||
TQ0111 | LDN-192960 | DYRK , Haspin Kinase | |
LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM). | |||
T11447 | GNF4877 | GSK-3 , DYRK | |
GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation cells. | |||
T40187 | GNF2133 | DYRK | |
GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes. | |||
T14980 | CLK-IN-T3 | DYRK , CDK | |
CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity. | |||
T7323 | BCI-215 | Phosphatase | |
BCI-215 causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling | |||
T14364 | AZ-Dyrk1B-33 | 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine | DYRK |
AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM. | |||
T4584 | BMS-813160 | BMS 813160 | CCR |
BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular. | |||
T4199 | Desmethyl-VS-5584 | PI3K , mTOR | |
Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. | |||
T3707 | GNE-3511 | GNE3511 | DNA Alkylation , MAPK |
GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors. | |||
T8409 | SYN1143 | RON-IN-1,AMG-1 | c-Met/HGFR |
SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively. | |||
T10616 | BRM/BRG1 ATP Inhibitor-1 | Epigenetic Reader Domain | |
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50... | |||
T4636 | Protein kinase inhibitors 1 | Others , DYRK | |
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM. | |||
T6104 | Cerdulatinib hydrochloride | Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride | MLK , c-Fms , Tyrosine Kinases , Hippo pathway , JAK , Syk |
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19... | |||
T12365 | PARP/PI3K-IN-1 | PARP , PI3K | |
PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic ... | |||
T37015 | Iprindole | 5-HT Receptor | |
Iprindole, a tricyclic indole antidepressant, is a dual weak inhibitor of noradrenaline and 5-HT uptake [1]. | |||
T22054 | BW 755C | Lipoxygenase | |
BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. | |||
T68018 | Tuvatexib | VDAC | |
Tuvatexib is a small molecule VDAC/HK2 dual modulator. | |||
T18975 | DIDS sodium salt | MDL101114ZA | VDAC , ABC |
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. | |||
T13148 | CHK-IN-1 | Chk | |
CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity. | |||
TP1111L | Tirzepatide Acetate(2023788-19-2 free base) | Glucagon Receptor | |
Tirzepatide acetate is a dual GIP / GLP-1 receptor agonist. | |||
T11383 | GDP366 | Survivin | |
GDP366, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. a dual inhibitor of survivin and Op18. | |||
T3692 | GNE-477 | GNE 477 | PI3K , mTOR |
GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor. | |||
T2457 | IRAK-1-4 Inhibitor I | IRAK-1/4 Inhibitor I,IRAK-1/4 Inhibitor | IRAK |
IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1. | |||
T2314 | PF-431396 | FAK , PYK2 | |
PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM). | |||
T12263L | NSC305787 hydrochloride | (Rac)-NSC305787 hydrochloride | Others |
NSC305787 hydrochloride ((Rac)-NSC305787 hydrochloride is a cell membrane permeable and selective and potent small molecule dual inhibitor of Cdc25 dual specificity phosphatase and EZR that displays antitumor activity in... | |||
T60040 | α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid | Others , Aminopeptidase | |
α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid was identified as possible dual inhibitors for hLTA4H and hLTC4S enzymes by the computer-aided methodology. | |||
T8374 | LJ570 | PPAR | |
LJ570 is the first PPARα/γ dual agonist (PPARα,PPARγ with EC50s of 1.05 and 0.12 μM, respectively[) | |||
TQ0252 | BAR502 | FXR , GPCR19 , Autophagy | |
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM). | |||
T15559 | TBK1/IKKε-IN-2 | IκB/IKK | |
TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε. | |||
T12596 | (4E)-SUN9221 | 5-HT Receptor , Adrenergic Receptor | |
(4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist that shows antihypertensive and antiplatelet aggregation activity in hypertensive rats. | |||
T34602 | Selatinib | EGFR | |
Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells. | |||
T11162 | EGFR-IN-8 | EGFR , c-Met/HGFR | |
EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC. EGFR-IN-8 is a dual EGFR and c-Met inhibitor. | |||
T6899 | MRT68921 | MRT68921 HCl | Autophagy |
MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. | |||
T6907 | NPS-1034 | NPS1034,NPS 1034 | Apoptosis , c-Met/HGFR , TAM Receptor |
NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively. | |||
T5643 | NG25 | MAPK | |
NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively. | |||
T13279L | Valemetostat | DS-3201 | Histone Methyltransferase |
Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor. | |||
T6099 | Setanaxib | GKT137831 | NADPH-oxidase , Ferroptosis , NADPH |
Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor. | |||
T0078 | Lapatinib | GSK572016,GW572016 | EGFR , Ferroptosis , Autophagy |
Lapatinib (GW572016) is a dual inhibitor of ErbB2/EGFR (IC50: 9.2/10.8 nM). |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1711 | Harmine | Telepathine | MAO , 5-HT Receptor , DYRK |
Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala. | |||
T2811 | Harmine hydrochloride | telepathine hydrochloride | 5-HT Receptor , DYRK , GluR |
Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus. | |||
T5759 | S-(+)-Marmesin | (+)-Marmesin,(S)-Marmesin,marmesin | Lipoxygenase , COX |
S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity. | |||
T2894 | Norcantharidin | Norcantharadine,Endothall anhydride | EGFR , c-Met/HGFR |
Norcantharidin (Norcantharadine) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers. | |||
TN4220 | Homobutein | 3-O-Methylbutein,2',4,4'-Trihydroxy-3-methoxychalcone | Antioxidant , NF-κB , HDAC , Parasite , Immunology/Inflammation related |
Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities. | |||
T5940 | Proxyphylline | 7-(2-Hydroxypropyl)theophylline | PDE , Adenosine Receptor |
Proxyphylline (7-(2-Hydroxypropyl)theophylline) is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and bronchodilator. | |||
T3000 | Magnolol | NSC 293099,5,5'-Diallyl-2,2'-biphenyldiol | NF-κB , Retinoid Receptor , Antibacterial , PPAR , p53 , Autophagy |
Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation. | |||
T5656 | (±)-Norcantharidin | Endothall anhydride,Norcantharidin | EGFR , c-Met/HGFR |
(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers. | |||
T10117 | 3'-O-Acetylhamaudol | Others | |
3'- O- Acetylhamaudol, isolated from the roots of Angelica japonica, exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation. | |||
TQ0180 | Chebulagic acid | SARS-CoV , Influenza Virus , Lipoxygenase , COX | |
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor. | |||
TN1956 | Mulberrofuran G | Phosphatase , HBV , Glucosidase | |
Mulberrofuran G is a small molecule compound from Morus alba L. It has anti-hepatitis B virus activity and protects against ischemic injury-induced cell death.Mulberrofuran G is a dual inhibitor of PTP1B and α-glucosidas... | |||
T2909 | Fraxetin | 7,8-dihydroxy-6-methoxy coumarin | Apoptosis , Others |
Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a m... | |||
TN5888 | Toddaculin | Others | |
Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in... | |||
T3417 | Amentoflavone | Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin | Apoptosis , P450 , Phospholipase , Reactive Oxygen Species , Opioid Receptor , COX , Antibacterial , RSV , Antifungal |
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib... | |||
TN1254 | 3'-Methoxydaidzein | Sodium Channel | |
3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively. 3'-Methoxydaidzein was specific for colla... | |||
T3S1612 | Kuwanon G | Moracenin B,Kuwanone G | Phosphatase , Antibacterial , Bombesin Receptor , AChR , AChE , Glucosidase |
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has a... | |||
TN1719 | Gymnestrogenin | Liver X Receptor | |
Gymnestrogenin has a dual LXRα±/α2 antagonistic profile. | |||
TN6050 | Macusine B | ||
Macusine B is a dual inhibitor, has almost equal inhibitory activity on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). | |||
TN2176 | Sanggenol A | Influenza Virus , Antifection | |
Sanggenol A inhibits influenza A viral and pneumococcal neuraminidase, hence functioning as a dual-acting anti-infective agent. | |||
T10238 | Aclacinomycin A hydrochloride | Aclarubicin hydrochloride | Proteasome |
Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinom... | |||
TN1532 | Crenulatin | BCL , Caspase | |
Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/L group, respectively; the mechanism is related to the altera... | |||
T40611 | (E)-Dehydrodiconiferyl alcohol | ||
(E)-Dehydrodiconiferyl alcohol is a potent dual inhibitor of hCA IX and hCA XII, effectively impeding the catalytic activity of both carbonic anhydrase isoforms. Additionally, (E)-Dehydrodiconiferyl alcohol exerts inhibi... | |||
TN4016 | Ethyl 2,4,6-trihydroxybenzoate | Liver X Receptor | |
Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells. It suppresses cellular ch... | |||
TN5091 | Tagitinin A | PPAR , Antifection | |
Tagitinin A is a plant insecticidal compound, it has phytotoxic activity, it shows significant inhibition of wheat coleoptile growth, seed germination, and the growth of STS and weeds. Tagitinin A is also a PPARα/γ dual ... | |||
TN5149 | Tirotundin | NF-κB , COX , PPAR | |
Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activation of NF-kappa B, thereby, the synthesis of inflammatory me... | |||
TN2169 | Saikogenin D | IL Receptor , Calcium Channel , Prostaglandin Receptor | |
Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellu... | |||
T79973 | Dehydrodiscretamine chloride | ||
Dehydrodiscretamine chloride, a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibits IC50 values of 17.8 μM and 118.8 μM, respectively. It also possesses antioxidant activity and is ut... | |||
T81629 | OAT1/3-IN-2 | ||
OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3 that demonstrates potential protective effects against Cys-Hg toxicity in HEK-OAT1 cells (10 μM) and may safeguard renal function. This compound is useful for... | |||
T81630 | OAT1/3-IN-1 | ||
OAT1/3-IN-1 (compound 7), a dual inhibitor of OAT1 and OAT3, demonstrates the ability to mitigate the toxicity of Cys-Hg in HEK-OAT1 cells at a concentration of 10 μM and offers potential kidney protection. This compound... | |||
T75544 | AChE/BChE-IN-11 | ||
AChE/BChE-IN-11 (compound 1) is a potent is a dual AChE and BChE inhibitor with IC 50 values of 70 and 71 μM for AChE and BChE , respectively. AChE/BChE-IN-11 is a natural product that could be isolated from the leaf of ... | |||
T79963 | Feralolide | ||
Feralolide, a dihydroisocoumarin from the methanolic extract of aloe vera resin, functions as a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC50 values of 55 μg/mL and 52 μg/mL, ... | |||
T36950 | Rubrofusarin triglucoside | ||
Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside inhibits human monoamine oxidase A (hMAO-A) with an IC50 of 85.5 μM[1]. [1]. Pradeep Paudel, et al.... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02127 | DUSP3 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Vaccinia H1-related phosphatase (VHR) is classified as a dual-specificity phosphatase (DUSP), and the other name is dual-specificity phosphatase 3 (DUSP3). DUSPs are a heterogeneous group of protein phosphatases that can... | |||
TMPY-03482 | DUSP3 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
Vaccinia H1-related phosphatase (VHR) is classified as a dual-specificity phosphatase (DUSP), and the other name is dual-specificity phosphatase 3 (DUSP3). DUSPs are a heterogeneous group of protein phosphatases that can... | |||
TMPJ-00996 | VHR Protein, Human, Recombinant (His) | Human | E. coli |
Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues... | |||
TMPY-02595 | DUSP14 Protein, Human, Recombinant (His & MBP) | Human | E. coli |
Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosph... | |||
TMPY-04380 | DYRK3 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Dual specificity tyrosine-phosphorylation-regulated kinase 3, also known as Regulatory erythroid kinase, REDK and DYRK3, is a nucleus protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase... | |||
TMPY-05449 | IL-33 Protein, Cynomolgus, Recombinant | Cynomolgus | E. coli |
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural... | |||
TMPY-02789 | IL-33 Protein, Canine, Recombinant | Canine | E. coli |
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural... | |||
TMPY-00861 | IL-33 Protein, Human, Recombinant | Human | E. coli |
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural... | |||
TMPY-04572 | MKK4 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is... | |||
TMPY-02412 | ENO1 Protein, Human, Recombinant (His) | Human | E. coli |
The ENO1 gene encodes a multifunctional enzyme that has been identified as a key component of the glycolytic pathway. ENO1 overexpression and post-translational modifications could be of diagnostic and prognostic value ... | |||
TMPY-03235 | BST2 Protein, Human, Recombinant (His) | Human | HEK293 |
BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demons... | |||
TMPY-00716 | CD89 Protein, Human, Recombinant (His) | Human | HEK293 |
FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This recep... | |||
TMPY-01608 | Decorin Protein, Human, Recombinant (His) | Human | HEK293 |
Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core p... | |||
TMPY-00978 | Progranulin Protein, Human, Recombinant (His) | Human | HEK293 |
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ... | |||
TMPY-04552 | AKT1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to ... | |||
TMPY-01030 | TFPI Protein, Human, Recombinant (His) | Human | HEK293 |
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. Wit... | |||
TMPY-04962 | FAP Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S... | |||
TMPY-04922 | FAP Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 |
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S... | |||
TMPY-02154 | FAP Protein, Human, Recombinant (His) | Human | HEK293 |
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S... | |||
TMPY-02590 | HMGB1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family consisting of three members, HMGB1, HMGB2, and HMGB3. HMGB1 is a DNA-binding nuclear protein, releas... | |||
TMPY-01848 | HMGB1 Protein, Human, Recombinant (aa 1-215, His) | Human | HEK293 |
High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family consisting of three members, HMGB1, HMGB2, and HMGB3. HMGB1 is a DNA-binding nuclear protein, releas... | |||
TMPY-00875 | Leptin Protein, Human, Recombinant | Human | E. coli |
Leptin is one of the most important hormones secreted by adipocytes, as an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine, and pro-inflammatory immu... | |||
TMPK-00798 | IGSF11 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Immunoglobulin superfamily member 11 (IgSF11), a homophilic adhesion molecule that preferentially expressed in the brain, is a dual-binding partner of the postsynaptic scaffolding protein PSD-95 and AMPA glutamate recept... | |||
TMPY-04546 | CLK3 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Dual specificity protein kinase CLK3, also known as CDC-like kinase 3, and CLK3, is a member of CMGC Ser/Thr protein kinase family and Lammer subfamily. Mammalian CLK is the prototype for a family of dual specificity ... | |||
TMPK-00634 | MSPR/Ron Protein, Human, Recombinant (His) | Human | HEK293 |
Macrophage-stimulating protein (MSP) is a serum protein belonging to the plasminogen-related growth factor family. The specific receptor for MSP is the RON (recepteur d'origine nantais) receptor tyrosine kinase - a membe... | |||
TMPH-01135 | CR1 Protein, Human, Recombinant (GST) | Human | E. coli |
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that... | |||
TMPK-00806 | GHR/Growth Hormone R Protein, Human, Recombinant (His) | Human | HEK293 |
Pegvisomant, a growth hormone receptor (GHR) antagonist, is a well-known drug that was designed to treat acromegaly. However, recent studies have indicated that the GHR is a "moonlighting" protein that may exhibit dual f... | |||
TMPH-00403 | Toxin A Protein, Clostridioides difficile, Recombinant (His) | Clostridioides difficile | E. coli |
Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long ch... | |||
TMPY-04544 | MEK2 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/... | |||
TMPY-04569 | MEK1 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
MEK1, also known as MAP2K1 and MKK1, is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kin... | |||
TMPY-04756 | MEK1 Protein, Mouse, Recombinant | Mouse | Baculovirus-Insect Cells |
MEK1, also known as MAP2K1 and MKK1, is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kin... | |||
TMPH-00031 | Aerolysin Protein, Aeromonas sobria, Recombinant (His & Myc) | Aeromonas sobria | E. coli |
These quantitative data support a model where 2-CysPrx and Cyp20-3, by interaction, form a redox-sensitive regulatory module in the chloroplast which is under control of the photosynthesis-linked stromal pH value, the re... | |||
TMPY-05095 | RAF1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds direct... | |||
TMPY-03672 | Survivin Protein, Human, Recombinant | Human | E. coli |
BIRC5, also known as Survivin and EPR-1, is a member of theIAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-... | |||
TMPY-03700 | S100A11 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of theS-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell pe... | |||
TMPY-01331 | S100A11 Protein, Human, Recombinant | Human | E. coli |
Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of theS-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell pe... | |||
TMPH-01642 | MELK Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineag... | |||
TMPY-04364 | MKK6 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ... | |||
TMPY-04749 | MKK6 Protein, Human, Recombinant (S207D, T211D) | Human | Baculovirus-Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ... | |||
TMPY-02764 | PTH Protein, Human, Recombinant (aa 32-65, GST) | Human | E. coli |
Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide. PTH elevates calcium level by dissolving the salts in bone and preventing their renal excr... | |||
TMPY-02977 | PDE1C Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds ... | |||
TMPY-04365 | MKK6 Protein, Human, Recombinant (S207D, T211D, His & GST) | Human | Baculovirus-Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ... | |||
TMPY-04748 | MKK6 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ... | |||
TMPY-01819 | PDE1B Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Pho... | |||
TMPY-02081 | PDE2A Protein, Human, Recombinant (aa 215-900, His) | Human | Baculovirus-Insect Cells |
cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 sub... | |||
TMPY-03191 | PTH Protein, Human, Recombinant (hFc) | Human | HEK293 |
Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide. PTH elevates calcium level by dissolving the salts in bone and preventing their renal excr... | |||
TMPY-04547 | PBK/TOPK Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the chara... | |||
TMPY-00073 | ENO1 Protein, Rat, Recombinant (His) | Rat | E. coli |
The ENO1 gene encodes a multifunctional enzyme that has been identified as a key component of the glycolytic pathway. ENO1 overexpression and post-translational modifications could be of diagnostic and prognostic value ... | |||
TMPH-02279 | YARS1 Protein, Human, Recombinant (GST) | Human | E. coli |
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation durin... | |||
TMPH-02278 | PTPN5 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation durin... | |||
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