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Neuroscience AChR

AChR

An acetylcholine receptor (abbreviated AChR) is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter.
Cat No. product name
T2939 ForskolinHOT Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
T21825 TAE-1 TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
T1083L Theophylline monohydrate Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize ade...
T0130 Physostigmine Salicylate Physostigmine, a parasympathomimetic alkaloid, is a reversible cholinesterase inhibitor. It extracts from the Calabar bean.
T0455 Clozapine Clozapine is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and display...
T1083 Theophylline Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant ac...
T1328 DL-trihexyphenidyl hydrochloride DL-trihexyphenidyl hydrochloride is a muscarinic antagonist.
T3126 Bethanechol chloride Bethanechol chloride is a slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in t...
T0375L Atropine sulfate monohydrate Atropine sulfate monohydrate, the sulfate salt of atropine, is a competitive muscarinic acetylcholine receptor antagonist.
T2387 Glycopyrrolate Glycopyrrolate is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthet...
T1221 Acetylcholine chloride Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride mim...
T2571 Benactyzine hydrochloride Benactyzine hydrochloride is a centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to inves...
T0052L Strychnine Sulfate In smaller doses, strychnine functions as a stimulant and an athletic performance-enhancer. The most common source is from the seeds of the Strychnos nux-vomica...
T0445 Promethazine Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
T6684 Succinylcholine Chloride Dihydrate Succinylcholine Chloride Dihydrate is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.
T2181 Scopolamine N-oxide HBr Scopolamine N-oxide HBr is an antagonist of the muscarinic acetylcholine.
T0364L Dibucaine hydrochloride Dibucaine hydrochloride, a long-acting local amide anestheticsis, is usually used for surface anesthesia.
T0018 Procainamide hydrochloride Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procain...
T0113 Mebhydrolin napadisylate Mebhydrolin (napadisylate) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
T6548 Irsogladine Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
T1049L Oxybutynin Oxybutynin is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.
T0594 Diphemanil mesylate Diphemanil methylsulfate, a quaternary ammonium anticholinergic, binds muscarinic acetylcholine receptors and thus decreases secretory excretion of stomach acid...
T7002 Trihexyphenidyl hydrochloride Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class.
T1594 Vecuronium bromide Vecuronium is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity.
T0802 Procaine hydrochloride
T1111 Pralidoxime Chloride Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by acetylcholinesterase or organophosphates inhibitors (nerve ag...
T0375 Atropine Atropine Sulfate is the sulfate salt of atropine, a naturally-occurring alkaloid isolated from the plant Atropa belladonna. Atropine functions as a sympathetic,...
T0177 Homatropine Bromide Homatropine Hydrobromide is the hydrobromide salt form of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. Homatropine, a compet...
T1612 Hodostin Hodostin is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.
T0051 Urethane Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T1199 Mitotan Mitotane is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormon...
T0287 Hexamethonium Bromide Hexamethonium Bromide, a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross t...
T0766 Promazine hydrochloride Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treat...
T1341 Nortropine Nortropine is used as muscarinic receptor antagonists.
T0818 Decamethonium bromide Decamethonium Bromide is a neuromuscular blocker and nicotinic AChR partial agonist.
T1215 Nicardipine hydrochloride Nicardipine Hydrochloride is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nica...
T0804 (+)-Pilocarpine hydrochloride Pilocarpine hydrochloride, a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy.
T0713 Drofenine hydrochloride Drofenine hydrochloride is an effective competitive inhibitor of BChE (Ki value: 3 uM).
T2285 EVP-6124 hydrochloride EVP-6124 hydrochloride is a new-type partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
T0375L2 Atropine sulfate Atropine sulfate is a competitive antagonist for muscarinic acetylcholine receptor.
T1682 Methacholine Chloride Methacholine chloride is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE ...
T1760 TBPB TBPB is an allosteric M1 mAChR agonist.
T0790 Carbaryl Carbaryl is a carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhi...
T6721 Vinblastine Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
T0427 Homatropine Methylbromide Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.
T1446 Bambuterol hydrochloride Bambuterol, a long-acting beta-adrenoceptor agonist, is utilized for the treating of asthma.
T2141 Mecamylamine hydrochloride Mecamylamine hydrochloride is a nicotinic antagonist, used as a ganglionic blocker in hypertension.
T0625 Theobromine 3, 7-Dimethylxanthine, a xanthine alkaloid, is used as a bronchodilator and as a vasodilator.
T3196 GNF7 GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.
T1229 Erdosteine Erdosteine is a homocysteine-derived thiol derivative with mucolytic and free radical scavenging properties. Erdosteine and its metabolites modulate mucus produ...
T0364 Dibucaine Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
T6575 LY2119620 LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.
T0296 Pempidine Pempidine is a nicotinic antagonist, has been used as a ganglionic blocker in the treatment of hypertension.
T1327 Nortriptyline hydrochloride Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia,...
T6115 Fostamatinib Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
T2984 Scopoletin Scopoletin is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE).
T2337 BMS303141 BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
T1484 Perindoprilat Perindoprilat is an angiotensin-converting enzyme inhibitor.
T1459 Cisatracurium besylate Cisatracurium Besylate is a nondepolarizing skeletal muscle relaxant for intravenous administration.
T2138 Oxyphencyclimine Hydrochloride Oxyphencyclimine Hydrochloride is a synthetic tertiary amine and antimuscarinic agent with antispasmodic and antisecretory activities.
T4286 Fmoc-Val-Ala-PAB Fmoc-Val-Ala-PAB is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RG...
T0269 Dichlorisone Acetate Dichlorisone Acetate is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
T1636 Paroxetine hydrochloride Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression.
T0072 Adiphenine hydrochloride Adiphenine hydrochloride, a nicotinic receptor inhibitor, can be used as an antispasmodic drug.
T1460 Dicyclomine hydrochloride Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.
T0103 Dipivefrin hydrochloride Dipivefrin that is available as an ophthalmic solution is a prodrug of adrenaline, which is used to treat glaucoma.
T6397 Atracurium besylate Atracurium besylate is a non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lac...
T0074L Chlorprothixene hydrochloride Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a ...
T0720 Gallamine triethiodide Gallamine Triethiodide, a synthetic inhibiting drug, is nondepolarizing.
T2182 Scopolamine HBr trihydrate Scopolamine hydrobromide is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ...
T0098 Ipratropium bromide monohydrate Ipratropium bromide is a muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for...
T1039 Choline chloride Choline chloride is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl...
T1072 Loxeen Pridinol Methanesulfonate Salt is used as an anticholinergic and as an antiparkinsonian agent.
T2319 Acotiamide hydrochloride Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the e...
T0665 2,6-Dihydroxypurine Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme. Xanthi...
T3023 Catharanthine sulfate Catharanthine inhibits nicotinic receptor-mediated diaphragm contractions.
T1069 Metoclopramide hydrochloride Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic.
T0064 Adenine Adenine, a purine derivative, is a nucleobase with various roles in biochemistry including cellular respiration, in the form of both the energy-rich ATP and NAD...
T3819 Acetylursolic acid Acetylursolic acid has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activitie...
T0765 4-Methylpyrazole Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenas...
T0794 Mepenzolate Bromide Mepenzolate Bromide is a muscarinic antagonist used to treat gastrointestinal conditions.
T1575 Nizatidine Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
T1266 Terfenadine Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistami...
T1006 Propantheline bromide Propantheline bromide competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gla...
T7500 Isoxazole Isoxazole is the inhibitor of acetylcholinesterase (AChE). The ligands of Isoxazole bind to and inhibit the Sxc- antiporter.
T1179 Tiotropium bromide Tiotropium is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a mus...
T0185 Escitalopram Escitalopram is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol upt...
T1628 Rivastigmine tartrate Rivastigmine tartrate is a carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment ...
T6426 Buclizine HCl Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. B...
T1567 Olanzapine Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
T1534 Darifenacin HBr Darifenacin is a selective muscarinic receptor antagonist used to treat urinary incontinence and overactive bladder syndrome.
T0731 N,N-Diethyl-m-toluamide DEET is the most general active composition in insect repellents.
T0268 Lobeline hydrochloride Lobeline hydrochloride is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes.
T6707 Tiotropium Bromide hydrate Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a mus...
T0024 Primidone Primidone is an anticonvulsant of the pyrimidinedione class.
T1668 Vinblastine sulfate Vinblastine sulfate can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
T0851 Pregnenolone Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
T1231 Pilocarpine nitrate Pilocarpine nitrate is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
T2183 Scopolamine butylbromide Scopolamine butylbromide is a competitive antagonist of mAChR (IC50: 55.3 ± 4.3 nM).
T6607 Nitenpyram Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.
T1049 Oxybutynin hydrochloride Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, and M3 subtypes of the mu...
T1281 Tropicamide Tropicamide is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide ...
T2390 Cevimeline hydrochloride hemihydrate Cevimeline hydrochloride hemihydrate is a novel muscarinic receptor agonist, used as a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
T3791 Atractyloside A Atractyloside is a glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILE...
T0099 Tolterodine tartrate Tolterodine Tartrate(PNU-200583E; Kabi-2234) is a potent antagonist for muscarinic receptor. It show selectivity for the urinary bladder and salivary glands in ...
T0253 Methscopolamine Methscopolamine (Pamine), as a natural plant alkaloid, is a muscarinic acetylcholine receptor blocker.
T0976 Propoxur Propoxur is an insecticide used to control cockroaches, flies, mosquitoes, and lawn and turf insects. Acute (short-term) exposure of humans to propoxur by inges...
T0962 L-Hyoscyamine L-Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine o...
T3026 (-)-Huperzine A Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibi...
T0172 Maprotiline hydrochloride Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, i...
T1472 Trospium chloride Trospium is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. Trospium has not been implicated in c...
T0302 Triflupromazine hydrochloride Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
T0162 Quetiapin Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapi...
T3619 VU 0357017 hydrochloride VU 0357017 hydrochloride is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.37 ± 0.15).
T2725 Scopolamine HBr Scopolamine hydrobromide is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ...
T1220 Ethidium bromide A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful ...
T1624 Neostigmine bromide Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine an...
T0156 Rocuronium bromide Rocuronium is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endot...
T6478 Donepezil HCl Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
T0401 Benzethonium chloride Benzethonium is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.
T1552 Itopride hydrochloride Itopride hydrochloride is an AChE and D2DR inhibitor.
T1540 Doxepin hydrochloride Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mec...
T0229 Rivastigmine Rivastigmine is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.
T2422 PNU 282987 PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μ...
T0166 Pancuronium bromide Pancuronium dibromide, a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide blocking neuromuscular transmiss...
T2663 GTS 21 dihydrochloride GTS 21 dihydrochloride is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.
T6950 PNU120596 PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.
T1657 Varenicline Tartrate Varenicline tartrate is a benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist. It is used for SMOKING CESSATION.
T0862 Diphenidol hydrochloride Diphenidol hydrochloride, a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.
T0997 Temephos Temefos is a cholinesterase inhibitor. Temefos is an organothiophosphate insecticide, used in the therapy of water infested with disease-carrying insects includ...
T3993 BQCA BQCA a highly selective allosteric modulator of the M1 mAChR.
T0786 Clidinium bromide Clidinium, a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effec...
T0684 Ribavirin Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T0703 Flavoxate hydrochloride Flavoxate Hydrochloride(DW-61 Hydrochloride), a muscarinic AChR antagonist, is used in the therapy of various urinary syndromes and as an antispasmodic.
T1320 Disopyramide A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) w...
T0236 Azatadine Maleate Azatadine dimaleate is an inhibitor for histamine(IC50=6.5 nM) and cholinergic(IC50=10 nM).
T6744 Methylbenactyzine Bromide Dimethadione is an anticonvulsant that is the active metabolite of trimethadione.
T2558 Cladribine Cladribine, an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.
T6618 Orphenadrine Citrate Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
T3324 Lycorine Lycorine inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
T2845 Imperatorin Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T2846 Isoimperatorin Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).
T0479 Cytisine Cytisine, an alkaloid, is found naturally in several plants.
T1202 (-)-Cotinine Cotinine is an alkaloid found in tobacco and is also the predominant metabolite of nicotine.
T3872 Nodakenin Nodakenin is a compound with anti-allergic and anti-inflammatory activities.
T2555 Aclidinium bromide Aclidinium is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis or emphysema. Aclidini...
T2198 Arecoline HBr Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist.
T0716 Molindone hydrochloride Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.
T2191 Tacrine hydrochloride hydrate Tacrine hydrochloride hydrate is a cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxan...
T3503 MC-Val-Cit-PABC-PNP MC-Val-Cit-PAB-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts ...
T0944 Levamisole hydrochloride Levamisole hydrochloride is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by...
T0999 Clevidipine butyrate Clevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when ...
T2172 SQ 22536 SQ 22536, the adenosine analogue 9-(Tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (Ictalurus mela...
T2759 Loganin Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed poten...
T0086 Galanthamine HBr Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
T3694 Tebanicline Tebanicline (ABT-594, Ebanicline) acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. T...
T3720 Tebanicline hydrochloride Tebanicline (ABT-594, Ebanicline), is an effective synthetic nicotinic (non-opioid) analgesic drug.
T6364 Desfesoterodine 5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.
T1542 Pirenzepine dihydrochloride Pirenzepine dihydrochloride is a selective M1 muscarinic receptor antagonist, inhibiting gastric secretion.
T6547 Ipratropium Bromide Ipratropium is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema.
T0464 Carbetapentane citrate Pentoxyverine Citrate, an antitussive (cough suppressant), is frequently used for a cough related to illnesses like the common cold.
T0111 Solifenacin succinate Solifenacin succinate is a quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the trea...
T6745 5-Iodotubercidin 5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphory...
T2782 Catharanthine Catharanthine suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).
T0338 Minaprine Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T1474 Otilonium bromide Otilonium Bromide, an antimuscarinic, is utilized as a spasmolytic agent.
T1475 Fesoterodine fumarate Fesoterodine Fumarate is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic pro...
T4289 Mc-Val-Ala-PAB Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC).
T4006 Pentostatin Pentostatin is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).
T9018 JHU 37160 JHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 rec...
T13301 Violanthin Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antiox...
T13129 Terodiline hydrochloride Terodiline hydrochloride is an antagonist of M1-selective muscarinic receptor (mAChR)(Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), b...
T13681 Epi-galantamine Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine inhibits AChE with an EC50 of 4...
T11351 Galanthamine N-Oxide Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC50 of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate acc...
T11366 Garcinol Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and an...
T10731 CDD0102 CDD0102 is a potent agonist of M1 Muscarinic receptor.
T13713 GP531 GP531 is a second-generation adenosine regulating agent. It is pharmacologically silent under basal conditions but increases localized endogenous adenosine dur...
T13256 UP202-56 UP202-56 is an adenosinergic agonist and is an adenosine analog.
T15655 KFM19 KFM19 is an effective and selective antagonist of the Adenosine receptor (A1-receptor) (IC50: 50 nM).
T12868 Sch412348 Sch412348 is a potent competitive the human adenosine A2A receptor antagonist with Ki of 0.6 nM and has >1000-fold selectivity over all other adenosine receptor...
T13373 YM17E YM17E is an acyl CoA:cholesterol acyltransferase (ACAT) inhibitor(IC50 of 44 nM in rabbit liver microsomes in vitro).
T19623 α-Muricholic acid α-Muricholic acid is the most abundant primary bile acid in rodents.
T15942 MK-7622 MK-7622 is a modulator of muscarinic M1 receptor positive allosteric.
T16353 Meseclazone Meseclazone has anti-inflammatory, analgesic, and antipyretic activity. Meseclazone shows inhibitory potency of secondary phase ADP aggregation.
T16417 Oxitropium Bromide Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary dis...
T16563 Pozanicline Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozan...
T8552 PSEM 89S TFA PSEM 89S TFA is a brain-penetrant and selective ion channels agonist, and is orthogonally selective for Q79G and L141F, respectively.
T16980 Taminadenant Taminadenant is an adenosine receptor antagonist.
T13066 TAK-071 TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).
T12825 Timepidium bromide Timepidium bromide is an agent of anticholinergic.
T17312 (+)-Phenserine (+)-Phenserine is a novel selective inhibitor of cholinesterase non-competitive (IC50: 45.3 μM).
T12481 Pipecuronium bromide Pipecuronium bromide is a powerful competitive antagonist of nAChR(Kd of 3.06 μM).
T13772 MHP 133 MHP 133 is a drug with multiple CNS targets(AChE with Ki of 69 μM).
T12107 MRS-3777 hemioxalate MRS-3777 hemioxalate is a selective antagonist of adenosine A3 receptor .
T12136 N-0861 racemate N-0861 racemate is the racemate of N-0861.
T12159 APNEA APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) is a potent and non-selective agonist of A3 adenosine receptor.
T12165 NAChR agonist 1 nAChR agonist 1 is a brain-permeable and orally efficacious positive allosteric  α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.
T12191 NBTGR NBTGR is a potent nucleoside transport inhibitor(adenosine uptake ,Ki of 70 nM).
T12446 Phenserine Phenserine is a derivative of Physostigmine and is annoncompetitive, long-acting and selective inhibitor of AChE.
T19084 1-Naphthyl acetate 1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the d...
T12766 RPR121056 RPR121056 is a Irinotecan metabolite, which is generated by CYP3A4. Irinotecan is an antineoplastic agent that inhibits topoisomerase type I.
T10058 A2B receptor antagonist 1 A2B receptor antagonist 1 (EXAMPLE 9B) is a potent A2B adenosine receptor antagonist extracted from patent WO 2009157938 A1.
T10914 Cyclodrine hydrochloride Cyclone hydrochloride is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist.
T11004 Desformylflustrabromine hydrochloride Desformylflustrabromine hydrochloride is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.
T14094 Acetamiprid Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with ...
T14140 Agaric acid Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus...
T14333 Asoxime dichloride Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride (HI-6) can be used...
T14944 CGS 15943 CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Re...
T14966 Cimetropium Bromide Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.
T17300 (-)-(S)-B-973B (-)-(S)-B-973B is an effective allosteric agonist and a positive allosteric modulator of α7 nAChR.
T22371 Mivacurium chloride Mivacurium chloride is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in...
TP2063 α-Conotoxin MII α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expres...
T23348 SEN 12333 α7 nicotinic acetylcholine receptor (nAChR) agonist
TN4456 Lucidadiol Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, it also possesses inhibitory activity against acetylcholinesterase...
TN4492 Mangostanol Mangostanol is an acetylcholinesterase (AChE) selective inhibitor.Mangostanol has anti-cancer activity, it shows significant activities against the CEM-SS cell ...
TN4600 Myrianthic acid Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low...
TN4652 Niazimicin Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity i...
TN4812 Pluviatolide (-)-Pluviatolide can inhibit electrically-induced and acetylcholine-induced contraction in the isolated guinea-pig ileum.
TN4837 Pseudotaraxasterol Pseudotaraxasterol shows cytotoxic activity against MOLT-4 cells.
TN5193 Tubotaiwine Tubotaiwine shows selective activity against L. infantum. Tubotaiwine and apparicine have affinity for adenosine receptors in the micromolar range and also have...
T22016 A 582941 A 582941 is a Selective agonist of α7 nAChR partial
TN4286 Isodunnianol Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from ...
T8770 Harmalol Harmalol is a bioactive beta-carboline and a member of the harmala alkaloids
T8725 A 582941 HCl (848591-90-2(free base)) A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
T8725 A 582941 HCl (848591-90-2(free base)) A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
T20539 Pirimiphos-methyl Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms.Pirimiphos-methyl is often used f...
T21153 Clothianidin Clothianidin, an insecticide, acts as an agonist of acetylcholine to stimulate nAChR, thereby activating post-synaptic acetylcholine receptors but not inhibitin...
T20812 Azamethiphos Azamethiphos, an organothiophosphate insecticide, is used in Atlantic salmon fish farming to control parasites.
T8868 4BP-TQS 4BP-TQS is an allosteric agonist of α7 nAChRs.
T9019 JHU 37152 JHU 37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 rec...
TN4426 Leojaponin Leojaponin is a prolyl oligopeptidase (POP) inhibitor. Leojaponin exhibits significant cytoprotective activities against glutamate-induced toxicity at concentra...
TN3875 Dipterocarpol Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory ...
T22448 Tropisetron Tropisetron is a α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
TN2505 1,5-Diphenylpentan-1-one 1,5-Diphenylpentan-1-one shows poor insecticidal and acetylcholinesterase inhibitory activities.
T8585 TA-03 TA-03 is a potent inhibitor of AChE in treatment of cognitive manifestation of AD.
Fr14127 2,3-Dihydrobenzofuran 2,3-Dihydrobenzofuran is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara. Coumaran can be used as a biopesticide. 2,3-dihydrobenzof...
Fr16605 Lupinine Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Lo...
PDK0015 4-Hydroxycoumarin 4-Hydroxycoumarin, a coumarin derivative.4-Hydroxycoumarin serves as an immediate precursor of 4-hydroxycoumarin (4HC) type anticoagulants (for example, warfari...
T21532 6-beta-Hydroxyhyoscyamine 6-beta-Hydroxyhyoscyamine and 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine.
T7224 (-)-Anabasine Anabasine is a nicotine analog that is an alkaloid found in tree tobacco (Nicotiana glauca). Anabasine has been used as an industrial insecticide and, since it ...
TL0018 Lobelin Inhalation challenge with capsaicin and rapid intravenous injection of Lobelin and alinamin indicated that peripheral c-fiber receptors were involved in the ind...
TN2504 1,5-Dihydroxyxanthone 1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have an...
TN3243 7-O-Methyleriodictyol 7-O-Methyleriodictyol inhibits the maximum contractions induced by acetylcholine or oxytocin.
TN3812 Dehydrovomifoliol Dehydrovomifoliol could be a marker of Polish heather honey. Dehydrovomifoliol exhibits moderate acetylcholinesterase (AChE) inhibitory activities. Dehydrovomif...
TN3285 8-Hydroxypinoresinol 8-Hydroxypinoresinol has antioxidant activity,it and phillygenin significantly reduce the cell injury by 3-morpholinosydnonimine (SIN-1), a ONOO- generator, may...
TN3287 8-Lavandulylkaempferol 8-Lavandulylkaempferol exhibits significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, re...
TN3380 Alloisoimperatorin Alloisoimperatorin is a candidate of AChE inhibitors, it displays potent antioxidant effects against the DPPH radical and against renal epithelial cell injury b...
TN3466 Atherosperminine Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong an...
TN3500 Beta-Amyrone beta-Amyrone has antifungal activity, it also shows a moderate activity against Chikungunya virus replication (EC50 =86 uM). beta-Amyrone exhibits anti-α-gluco...
TN3550 Buxbodine B Buxbodine B has weak anti-AChE activity with IC50 values in the range of 10.8-98μM.
TN3696 Conodurine Conodurine shows leishmanicidal and antibacterial activities, it shows inhibition activity for acetyl (AChE) and butyrylcholinesterase (BuChE).
TN3744 Cyclomorusin Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of ...
T12020 Metixene hydrochloride Metixene hydrochloride is an anticholinergic antiparkinsonian agent.
TN2247 Swertisin Swertisin, a novel herbal biomolecule, shows a strong antihyperglycemic action. Swertisin is an adenosine A1 receptor antagonist, is known to have antidiabetic,...
T4246 Varenicline Varenicline is a Selective α4β2 nicotinic acetylcholine receptor partial agonist.
T7124 Dinotefuran Dinotefuran is an insecticide of the neonicotinoid class for control of insect pests such as aphids, whiteflies, thrips, leafhoppers, leafminers. Its mechanism...
T4997 Umeclidinium bromide Umeclidinium bromide is a novel mAChR antagonist.
T4981 Anisotropine Methylbromide Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.
T5081 Adenine hydrochloride hydrate Adenine is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfect...
T5476 MAChr-in-1 mAChR-IN-1 is muscarinic cholinergic receptor(mAChR) antagonist (IC50=17 nM).
T5655 MAChR-IN-1 hydrochloride mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm.
T5721 Dehydroevodiamine hydrochloride Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitr...
T5855 Edrophonium chloride Edrophonium chloride is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specifi...
T5940 Proxyphylline Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and...
T4986 Imidafenacin Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM.
T5805 Norarecoline hydrochloride Norarecoline hydrochloride is a muscarinic agonist.
T7193 Encenicline Encenicline is a selective α7 nicotinic acetylcholine receptor (nAChRs) agonist in development for treating cognitive impairment in schizophrenia and Alzheime...
T7114 GALANTHAMINONE Galanthaminone is a cholinesterase (AChE) inhibitor, is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
T7340 NECA NECA is an agonist of Adenosine receptor, increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier mo...
T7392 Revefenacin Revefenacin is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.
T7555 Piperidolate hydrochloride Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylchol...
T7465 4-Methylbenzylidene camphor 4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations ,specifically UV B radiation, also has estrogenic activ...
T7561 Benzetimide hydrochloride Benzetimide hydrochloride is an antagonist of muscarinic acetylcholine receptor.treatment neuroleptic-induced parkinsonism.
T4960 VASICINE Vasicine is oxytocic and abortifacient agents.Vasicine, a potential natural cholinesterase inhibitor, has been in development for treatment of Alzheimer's disea...
T5149 MC-Val-Cit-PAB MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this link...
T7591 Coluracetam Coluracetam(MKC-231) is a Choline Uptake Enhancer.
T7052 Gnetol Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly su...
T4466 Pitofenone hydrochloride Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 3...
T2S1720 Huperzine B 1. Huperzine-B is a efficient inhibitor of human brain AChE. 2. Huperzine-B can enhance ognitive and protect neuro, may be potentially new drug candidates for A...
T7041 Donepezil Donepezil is a piperidine-based, potent, specific, and reversible inhibitor of acetylcholinesterase (AChE). It can be used for the treatment of mild to moderate...
T6S2356 (+)-Corynoline 1. Corynoline is an acetylcholinesterase inhibitor.
T4439 Choline glycerophosphate Glycerylphosphorylcholine is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have ...
T5S0802 Palmatine 1. Palmatine is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has be...
T3865 Beta-Eudesmol β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, incl...
T3S0478 Scopolamine 1. Scopolamine, a nonselective muscarinic receptor antagonist, induces distinct behaviors of attenuated motility and C-like hyperactivity. 2. Scopolamine can in...
T5051 Isopropamide Iodide Isopropamide iodide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders. It also acts as a ...
T5S2361 Epiberberine 1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1...
T4S1619 Hyoscyamine sulfate hydrate Hyoscyamine Sulfate is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus ni...
T2S1181 Aloenin A 1. Aloenin and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.
T4S0111 Hupehenine Hupehenine is a steriodal alkaloid extracted from the bulbs of Fritillaria Hupehensis, with the potential for inhibiting acetylcholine, antagonism for muscarini...
T3S1612 Kuwanon G 1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment fo...
T5S1025 Picfeltarraenin IA 1. Picfeltarraenin IA, IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.
T4668 ABT-702 dihydrochloride ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor.
T3767 Polygalacic acid Polygalacic acid(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increases choline ace...
T7422 CCMI CCMI is a potent and selective modulator of α7 nAChR-positive allosteric.
T7736 2-Chloroadenosine 2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors( Ki:300, 80, and 1,900 nM, respectively...
TN2131 Questin Questin has promising inhibitory potential against AChE, BChE, and BACE1, it may be used in the development of therapeutic or preventive agents for Alzheimer's ...
TN1653 Fustin Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
TN1305 6-Ethoxydihydrosanguinarine 6-Ethoxydihydrosanguinarine shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 valu...
TN1409 Asimilobine (-)-Asimilobine shows antioxidative, anti-acetylcholinesterase (AChE), anti-α±-glucosidase, anti-leishmanial and anti-fungal activities; it displays weak inhi...
TN1472 Cassiaside Cassiaside has significant hepato-protective effects against galactosamine damage, which is higher than that of silybin from Silybum marianum.
TN1527 Corynoxidine Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains. It inhibits acetylcholinesterase activ...
TN1544 D-Menthol D-Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in ...
TN1559 Dehydrodicentrine Dehydrodicentrine showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 value of 2.98 μM.
TN1645 Flavokawain C Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cyc...
TN1673 Garcinone C Garcinone C is a potent inhibitor of AChE.
TN1124 Neoeriocitrin Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is...
TN1736 Hibifolin Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-am...
TN1798 Isorosmanol Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions...
TN1799 Isorubrofusarin 10-gentiobioside Isorubrofusarin 10-gentiobioside shows promising inhibitory activity against AChE/BACE1.
TN1848 Kuwanon E Kuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acety...
TN1858 Leptomerine Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity.
TN1899 Lycoramine Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
TN1899 Lycoramine Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
TN2067 Picfeltarraenin X Picfeltarraenin X shows stronger AChE inhibition than the known AChE inhibitor Tacrine.
TN1248 3-Epioleanolic acid 3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affect...
TN1091 Dehydronuciferine Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn. Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
T7640 Aldicarb sulfone Aldicarb sulfone is a cholinesterase inhibitor .
T7955 EB-3D EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
T7695 PNU-282987 S enantiomer free base PNU-282987 S enantiomer free base is an  agonist of α7 nicotinic acetylcholine receptor (α7 nAChR).
T7405 Piperidolate Piperidolate inhibits intestinal cramp induced by acetylcholine
TQ0117 A-867744 A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).
TQ0304 Metixene hydrochloride hydrate Metixene is an anticholinergic antiparkinsonian agent, potently inhibits the binding of quinuclidinyl to the muscarinic receptor in rat brain cortical tissue (I...
T7780 AVex-73 AVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
T8193 Thujone Thujone is an inhibitor of  ACh with an IC50 value of 24.7μM.
T4S1725 Galanthamine Galanthamine is an acetylcholinesterase (AChE)inhibitor(IC50 : 500 nM), can reduce brain damage induced by hypoxia-ischemia.
T8306 Epiberberine (chloride) Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.0...
T7884 NS 1738 NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs)
TN1030 N-p-trans-Coumaroyltyramine N-p-trans-Coumaroyltyramine is a natural product, is an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits ...
T7813 α-MSH α-MSH is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
T7895 Syn-Ake acetate Syn-Ake acetate is a muscarinic acetylcholine receptor antagonist.
T7853 Pachycarpine Pachycarpine is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent
T8007 VU0238429 VU0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).
T8224 VU0119498 VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.
T8219 VU0238441 VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM.
T8383 Cyclopentolate Hydrochloride Cyclopentolate Hydrochloride is a muscarinic acetylcholine receptors antagonist with Kis of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively.
T8318 BNC210 BNC210 is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression.
T0780 Mestinon Pyridostigmine bromide is a cholinesterase inhibitor with a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravi...
Forskolin HOT
T2939CAS 66575-29-9
Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
TAE-1
T21825CAS 1414469-59-2
TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
Theophylline monohydrate
T1083LCAS 5967-84-0
Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize ade...
Physostigmine Salicylate
T0130CAS 57-64-7
Physostigmine, a parasympathomimetic alkaloid, is a reversible cholinesterase inhibitor. It extracts from the Calabar bean.
Clozapine
T0455CAS 5786-21-0
Clozapine is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and display...
Theophylline
T1083CAS 58-55-9
Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant ac...
DL-trihexyphenidyl hydrochloride
T1328CAS 58947-95-8
DL-trihexyphenidyl hydrochloride is a muscarinic antagonist.
Bethanechol chloride
T3126CAS 590-63-6
Bethanechol chloride is a slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in t...
Atropine sulfate monohydrate
T0375LCAS 5908-99-6
Atropine sulfate monohydrate, the sulfate salt of atropine, is a competitive muscarinic acetylcholine receptor antagonist.
Glycopyrrolate
T2387CAS 596-51-0
Glycopyrrolate is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthet...
Acetylcholine chloride
T1221CAS 60-31-1
Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride mim...
Benactyzine hydrochloride
T2571CAS 57-37-4
Benactyzine hydrochloride is a centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to inves...
Strychnine Sulfate
T0052LCAS 60-41-3
In smaller doses, strychnine functions as a stimulant and an athletic performance-enhancer. The most common source is from the seeds of the Strychnos nux-vomica...
Promethazine
T0445CAS 60-87-7
Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
Succinylcholine Chloride Dihydrate
T6684CAS 6101-15-1
Succinylcholine Chloride Dihydrate is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.
Scopolamine N-oxide HBr
T2181CAS 6106-81-6
Scopolamine N-oxide HBr is an antagonist of the muscarinic acetylcholine.
Dibucaine hydrochloride
T0364LCAS 61-12-1
Dibucaine hydrochloride, a long-acting local amide anestheticsis, is usually used for surface anesthesia.
Procainamide hydrochloride
T0018CAS 614-39-1
Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procain...
Mebhydrolin napadisylate
T0113CAS 6153-33-9
Mebhydrolin (napadisylate) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
Irsogladine
T6548CAS 57381-26-7
Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
Oxybutynin
T1049LCAS 5633-20-5
Oxybutynin is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.
Diphemanil mesylate
T0594CAS 62-97-5
Diphemanil methylsulfate, a quaternary ammonium anticholinergic, binds muscarinic acetylcholine receptors and thus decreases secretory excretion of stomach acid...
Trihexyphenidyl hydrochloride
T7002CAS 52-49-3
Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class.
Vecuronium bromide
T1594CAS 50700-72-6
Vecuronium is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity.
Procaine hydrochloride
T0802CAS 51-05-8
Pralidoxime Chloride
T1111CAS 51-15-0
Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by acetylcholinesterase or organophosphates inhibitors (nerve ag...
Atropine
T0375CAS 51-55-8
Atropine Sulfate is the sulfate salt of atropine, a naturally-occurring alkaloid isolated from the plant Atropa belladonna. Atropine functions as a sympathetic,...
Homatropine Bromide
T0177CAS 51-56-9
Homatropine Hydrobromide is the hydrobromide salt form of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. Homatropine, a compet...
Hodostin
T1612CAS 51-60-5
Hodostin is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.
Urethane
T0051CAS 51-79-6
Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
Mitotan
T1199CAS 53-19-0
Mitotane is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormon...
Hexamethonium Bromide
T0287CAS 55-97-0
Hexamethonium Bromide, a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross t...
Promazine hydrochloride
T0766CAS 53-60-1
Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treat...
Nortropine
T1341CAS 538-09-0
Nortropine is used as muscarinic receptor antagonists.
Decamethonium bromide
T0818CAS 541-22-0
Decamethonium Bromide is a neuromuscular blocker and nicotinic AChR partial agonist.
Nicardipine hydrochloride
T1215CAS 54527-84-3
Nicardipine Hydrochloride is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nica...
(+)-Pilocarpine hydrochloride
T0804CAS 54-71-7
Pilocarpine hydrochloride, a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy.
Drofenine hydrochloride
T0713CAS 548-66-3
Drofenine hydrochloride is an effective competitive inhibitor of BChE (Ki value: 3 uM).
EVP-6124 hydrochloride
T2285CAS 550999-74-1
EVP-6124 hydrochloride is a new-type partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
Atropine sulfate
T0375L2CAS 55-48-1
Atropine sulfate is a competitive antagonist for muscarinic acetylcholine receptor.
Methacholine Chloride
T1682CAS 62-51-1
Methacholine chloride is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE ...
TBPB
T1760CAS 634616-95-8
TBPB is an allosteric M1 mAChR agonist.
Carbaryl
T0790CAS 63-25-2
Carbaryl is a carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhi...
Vinblastine
T6721CAS 865-21-4
Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
Homatropine Methylbromide
T0427CAS 80-49-9
Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.
Bambuterol hydrochloride
T1446CAS 81732-46-9
Bambuterol, a long-acting beta-adrenoceptor agonist, is utilized for the treating of asthma.
Mecamylamine hydrochloride
T2141CAS 826-39-1
Mecamylamine hydrochloride is a nicotinic antagonist, used as a ganglionic blocker in hypertension.
Theobromine
T0625CAS 83-67-0
3, 7-Dimethylxanthine, a xanthine alkaloid, is used as a bronchodilator and as a vasodilator.
GNF7
T3196CAS 839706-07-9
GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.
Erdosteine
T1229CAS 84611-23-4
Erdosteine is a homocysteine-derived thiol derivative with mucolytic and free radical scavenging properties. Erdosteine and its metabolites modulate mucus produ...
Dibucaine
T0364CAS 85-79-0
Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
LY2119620
T6575CAS 886047-22-9
LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.
Pempidine
T0296CAS 79-55-0
Pempidine is a nicotinic antagonist, has been used as a ganglionic blocker in the treatment of hypertension.
Nortriptyline hydrochloride
T1327CAS 894-71-3
Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia,...
Fostamatinib
T6115CAS 901119-35-5
Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
Scopoletin
T2984CAS 92-61-5
Scopoletin is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE).
BMS303141
T2337CAS 943962-47-8
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
Perindoprilat
T1484CAS 95153-31-4
Perindoprilat is an angiotensin-converting enzyme inhibitor.
Cisatracurium besylate
T1459CAS 96946-42-8
Cisatracurium Besylate is a nondepolarizing skeletal muscle relaxant for intravenous administration.
Oxyphencyclimine Hydrochloride
T2138CAS 125-52-0
Oxyphencyclimine Hydrochloride is a synthetic tertiary amine and antimuscarinic agent with antispasmodic and antisecretory activities.
Fmoc-Val-Ala-PAB
T4286CAS 1394238-91-5
Fmoc-Val-Ala-PAB is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RG...
Dichlorisone Acetate
T0269CAS 79-61-8
Dichlorisone Acetate is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
Paroxetine hydrochloride
T1636CAS 78246-49-8
Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression.
Adiphenine hydrochloride
T0072CAS 50-42-0
Adiphenine hydrochloride, a nicotinic receptor inhibitor, can be used as an antispasmodic drug.
Dicyclomine hydrochloride
T1460CAS 67-92-5
Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.
Dipivefrin hydrochloride
T0103CAS 64019-93-8
Dipivefrin that is available as an ophthalmic solution is a prodrug of adrenaline, which is used to treat glaucoma.
Atracurium besylate
T6397CAS 64228-81-5
Atracurium besylate is a non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lac...
Chlorprothixene hydrochloride
T0074LCAS 6469-93-8
Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a ...
Gallamine triethiodide
T0720CAS 65-29-2
Gallamine Triethiodide, a synthetic inhibiting drug, is nondepolarizing.
Scopolamine HBr trihydrate
T2182CAS 6533-68-2
Scopolamine hydrobromide is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ...
Ipratropium bromide monohydrate
T0098CAS 66985-17-9
Ipratropium bromide is a muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for...
Choline chloride
T1039CAS 67-48-1
Choline chloride is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl...
Loxeen
T1072CAS 6856-31-1
Pridinol Methanesulfonate Salt is used as an anticholinergic and as an antiparkinsonian agent.
Acotiamide hydrochloride
T2319CAS 773092-05-0
Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the e...
2,6-Dihydroxypurine
T0665CAS 69-89-6
Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme. Xanthi...
Catharanthine sulfate
T3023CAS 70674-90-7
Catharanthine inhibits nicotinic receptor-mediated diaphragm contractions.
Metoclopramide hydrochloride
T1069CAS 7232-21-5
Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic.
Adenine
T0064CAS 73-24-5
Adenine, a purine derivative, is a nucleobase with various roles in biochemistry including cellular respiration, in the form of both the energy-rich ATP and NAD...
Acetylursolic acid
T3819CAS 7372-30-7
Acetylursolic acid has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activitie...
4-Methylpyrazole
T0765CAS 7554-65-6
Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenas...
Mepenzolate Bromide
T0794CAS 76-90-4
Mepenzolate Bromide is a muscarinic antagonist used to treat gastrointestinal conditions.
Nizatidine
T1575CAS 76963-41-2
Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
Terfenadine
T1266CAS 50679-08-8
Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistami...
Propantheline bromide
T1006CAS 50-34-0
Propantheline bromide competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gla...
Isoxazole
T7500CAS 288-14-2
Isoxazole is the inhibitor of acetylcholinesterase (AChE). The ligands of Isoxazole bind to and inhibit the Sxc- antiporter.
Tiotropium bromide
T1179CAS 136310-93-5
Tiotropium is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a mus...
Escitalopram
T0185CAS 128196-01-0
Escitalopram is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol upt...
Rivastigmine tartrate
T1628CAS 129101-54-8
Rivastigmine tartrate is a carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment ...
Buclizine HCl
T6426CAS 129-74-8
Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. B...
Olanzapine
T1567CAS 132539-06-1
Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
Darifenacin HBr
T1534CAS 133099-07-7
Darifenacin is a selective muscarinic receptor antagonist used to treat urinary incontinence and overactive bladder syndrome.
N,N-Diethyl-m-toluamide
T0731CAS 134-62-3
DEET is the most general active composition in insect repellents.
Lobeline hydrochloride
T0268CAS 134-63-4
Lobeline hydrochloride is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes.
Tiotropium Bromide hydrate
T6707CAS 139404-48-1
Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a mus...
Primidone
T0024CAS 125-33-7
Primidone is an anticonvulsant of the pyrimidinedione class.
Vinblastine sulfate
T1668CAS 143-67-9
Vinblastine sulfate can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
Pregnenolone
T0851CAS 145-13-1
Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
Pilocarpine nitrate
T1231CAS 148-72-1
Pilocarpine nitrate is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
Scopolamine butylbromide
T2183CAS 149-64-4
Scopolamine butylbromide is a competitive antagonist of mAChR (IC50: 55.3 ± 4.3 nM).
Nitenpyram
T6607CAS 150824-47-8
Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.
Oxybutynin hydrochloride
T1049CAS 1508-65-2
Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, and M3 subtypes of the mu...
Tropicamide
T1281CAS 1508-75-4
Tropicamide is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide ...
Cevimeline hydrochloride hemihydrate
T2390CAS 153504-70-2
Cevimeline hydrochloride hemihydrate is a novel muscarinic receptor agonist, used as a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
Atractyloside A
T3791CAS 126054-77-1
Atractyloside is a glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILE...
Tolterodine tartrate
T0099CAS 124937-52-6
Tolterodine Tartrate(PNU-200583E; Kabi-2234) is a potent antagonist for muscarinic receptor. It show selectivity for the urinary bladder and salivary glands in ...
Methscopolamine
T0253CAS 155-41-9
Methscopolamine (Pamine), as a natural plant alkaloid, is a muscarinic acetylcholine receptor blocker.
Propoxur
T0976CAS 114-26-1
Propoxur is an insecticide used to control cockroaches, flies, mosquitoes, and lawn and turf insects. Acute (short-term) exposure of humans to propoxur by inges...
L-Hyoscyamine
T0962CAS 101-31-5
L-Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine o...
(-)-Huperzine A
T3026CAS 102518-79-6
Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibi...
Maprotiline hydrochloride
T0172CAS 10347-81-6
Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, i...
Trospium chloride
T1472CAS 10405-02-4
Trospium is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. Trospium has not been implicated in c...
Triflupromazine hydrochloride
T0302CAS 1098-60-8
Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
Quetiapin
T0162CAS 111974-69-7
Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapi...
VU 0357017 hydrochloride
T3619CAS 1135242-13-5
VU 0357017 hydrochloride is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.37 ± 0.15).
Scopolamine HBr
T2725CAS 114-49-8
Scopolamine hydrobromide is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ...
Ethidium bromide
T1220CAS 1239-45-8
A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful ...
Neostigmine bromide
T1624CAS 114-80-7
Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine an...
Rocuronium bromide
T0156CAS 119302-91-9
Rocuronium is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endot...
Donepezil HCl
T6478CAS 120011-70-3
Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
Benzethonium chloride
T0401CAS 121-54-0
Benzethonium is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.
Itopride hydrochloride
T1552CAS 122892-31-3
Itopride hydrochloride is an AChE and D2DR inhibitor.
Doxepin hydrochloride
T1540CAS 1229-29-4
Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mec...
Rivastigmine
T0229CAS 123441-03-2
Rivastigmine is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.
PNU 282987
T2422CAS 123464-89-1
PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μ...
Pancuronium bromide
T0166CAS 15500-66-0
Pancuronium dibromide, a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide blocking neuromuscular transmiss...
GTS 21 dihydrochloride
T2663CAS 156223-05-1
GTS 21 dihydrochloride is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.
PNU120596
T6950CAS 501925-31-1
PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.
Varenicline Tartrate
T1657CAS 375815-87-5
Varenicline tartrate is a benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist. It is used for SMOKING CESSATION.
Diphenidol hydrochloride
T0862CAS 3254-89-5
Diphenidol hydrochloride, a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.
Temephos
T0997CAS 3383-96-8
Temefos is a cholinesterase inhibitor. Temefos is an organothiophosphate insecticide, used in the therapy of water infested with disease-carrying insects includ...
BQCA
T3993CAS 338747-41-4
BQCA a highly selective allosteric modulator of the M1 mAChR.
Clidinium bromide
T0786CAS 3485-62-9
Clidinium, a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effec...
Ribavirin
T0684CAS 36791-04-5
Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
Flavoxate hydrochloride
T0703CAS 3717-88-2
Flavoxate Hydrochloride(DW-61 Hydrochloride), a muscarinic AChR antagonist, is used in the therapy of various urinary syndromes and as an antispasmodic.
Disopyramide
T1320CAS 3737-09-5
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) w...
Azatadine Maleate
T0236CAS 3978-86-7
Azatadine dimaleate is an inhibitor for histamine(IC50=6.5 nM) and cholinergic(IC50=10 nM).
Methylbenactyzine Bromide
T6744CAS 3166-62-9
Dimethadione is an anticonvulsant that is the active metabolite of trimethadione.
Cladribine
T2558CAS 4291-63-8
Cladribine, an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.
Orphenadrine Citrate
T6618CAS 4682-36-4
Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
Lycorine
T3324CAS 476-28-8
Lycorine inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
Imperatorin
T2845CAS 482-44-0
Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
Isoimperatorin
T2846CAS 482-45-1
Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).
Cytisine
T0479CAS 485-35-8
Cytisine, an alkaloid, is found naturally in several plants.
(-)-Cotinine
T1202CAS 486-56-6
Cotinine is an alkaloid found in tobacco and is also the predominant metabolite of nicotine.
Nodakenin
T3872CAS 495-31-8
Nodakenin is a compound with anti-allergic and anti-inflammatory activities.
Aclidinium bromide
T2555CAS 320345-99-1
Aclidinium is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis or emphysema. Aclidini...
Arecoline HBr
T2198CAS 300-08-3
Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist.
Molindone hydrochloride
T0716CAS 15622-65-8
Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.
Tacrine hydrochloride hydrate
T2191CAS 206658-92-6
Tacrine hydrochloride hydrate is a cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxan...
MC-Val-Cit-PABC-PNP
T3503CAS 159857-81-5
MC-Val-Cit-PAB-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts ...
Levamisole hydrochloride
T0944CAS 16595-80-5
Levamisole hydrochloride is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by...
Clevidipine butyrate
T0999CAS 167221-71-8
Clevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when ...
SQ 22536
T2172CAS 17318-31-9
SQ 22536, the adenosine analogue 9-(Tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (Ictalurus mela...
Loganin
T2759CAS 18524-94-2
Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed poten...
Galanthamine HBr
T0086CAS 1953-04-4
Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
Tebanicline
T3694CAS 198283-73-7
Tebanicline (ABT-594, Ebanicline) acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. T...
Tebanicline hydrochloride
T3720CAS 203564-54-9
Tebanicline (ABT-594, Ebanicline), is an effective synthetic nicotinic (non-opioid) analgesic drug.
Desfesoterodine
T6364CAS 207679-81-0
5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.
Pirenzepine dihydrochloride
T1542CAS 29868-97-1
Pirenzepine dihydrochloride is a selective M1 muscarinic receptor antagonist, inhibiting gastric secretion.
Ipratropium Bromide
T6547CAS 22254-24-6
Ipratropium is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema.
Carbetapentane citrate
T0464CAS 23142-01-0
Pentoxyverine Citrate, an antitussive (cough suppressant), is frequently used for a cough related to illnesses like the common cold.
Solifenacin succinate
T0111CAS 242478-38-2
Solifenacin succinate is a quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the trea...
5-Iodotubercidin
T6745CAS 24386-93-4
5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphory...
Catharanthine
T2782CAS 2468-21-5
Catharanthine suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).
Minaprine
T0338CAS 25905-77-5
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
Otilonium bromide
T1474CAS 26095-59-0
Otilonium Bromide, an antimuscarinic, is utilized as a spasmolytic agent.
Fesoterodine fumarate
T1475CAS 286930-03-8
Fesoterodine Fumarate is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic pro...
Mc-Val-Ala-PAB
T4289CAS 1870916-87-2
Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC).
Pentostatin
T4006CAS 53910-25-1
Pentostatin is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).
JHU 37160
T9018CAS 2369979-68-8
JHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 rec...
Violanthin
T13301CAS 40581-17-7
Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antiox...
Terodiline hydrochloride
T13129CAS 7082-21-5
Terodiline hydrochloride is an antagonist of M1-selective muscarinic receptor (mAChR)(Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), b...
Epi-galantamine
T13681CAS 1668-85-5
Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine inhibits AChE with an EC50 of 4...
Galanthamine N-Oxide
T11351CAS 134332-50-6
Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC50 of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate acc...
Garcinol
T11366CAS 78824-30-3
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and an...
CDD0102
T10731CAS 146422-58-4
CDD0102 is a potent agonist of M1 Muscarinic receptor.
GP531
T13713CAS 142344-87-4
GP531 is a second-generation adenosine regulating agent. It is pharmacologically silent under basal conditions but increases localized endogenous adenosine dur...
UP202-56
T13256CAS 163838-04-8
UP202-56 is an adenosinergic agonist and is an adenosine analog.
KFM19
T15655CAS 133058-72-7
KFM19 is an effective and selective antagonist of the Adenosine receptor (A1-receptor) (IC50: 50 nM).
Sch412348
T12868CAS 377727-26-9
Sch412348 is a potent competitive the human adenosine A2A receptor antagonist with Ki of 0.6 nM and has >1000-fold selectivity over all other adenosine receptor...
YM17E
T13373CAS 124900-72-7
YM17E is an acyl CoA:cholesterol acyltransferase (ACAT) inhibitor(IC50 of 44 nM in rabbit liver microsomes in vitro).
α-Muricholic acid
T19623CAS 2393-58-0
α-Muricholic acid is the most abundant primary bile acid in rodents.
MK-7622
T15942CAS 1227923-29-6
MK-7622 is a modulator of muscarinic M1 receptor positive allosteric.
Meseclazone
T16353CAS 29053-27-8
Meseclazone has anti-inflammatory, analgesic, and antipyretic activity. Meseclazone shows inhibitory potency of secondary phase ADP aggregation.
Oxitropium Bromide
T16417CAS 30286-75-0
Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary dis...
Pozanicline
T16563CAS 161417-03-4
Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozan...
PSEM 89S TFA
T8552CAS 1336913-03-1
PSEM 89S TFA is a brain-penetrant and selective ion channels agonist, and is orthogonally selective for Q79G and L141F, respectively.
Taminadenant
T16980CAS 1337962-47-6
Taminadenant is an adenosine receptor antagonist.
TAK-071
T13066CAS 1820812-16-5
TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).
Timepidium bromide
T12825CAS 35035-05-3
Timepidium bromide is an agent of anticholinergic.
(+)-Phenserine
T17312CAS 116839-68-0
(+)-Phenserine is a novel selective inhibitor of cholinesterase non-competitive (IC50: 45.3 μM).
Pipecuronium bromide
T12481CAS 52212-02-9
Pipecuronium bromide is a powerful competitive antagonist of nAChR(Kd of 3.06 μM).
MHP 133
T13772CAS 147340-43-0
MHP 133 is a drug with multiple CNS targets(AChE with Ki of 69 μM).
MRS-3777 hemioxalate
T12107CAS 1186195-57-2
MRS-3777 hemioxalate is a selective antagonist of adenosine A3 receptor .
N-0861 racemate
T12136CAS 121241-87-0
N-0861 racemate is the racemate of N-0861.
APNEA
T12159CAS 89705-21-5
APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) is a potent and non-selective agonist of A3 adenosine receptor.
nAChR agonist 1
T12165CAS 1394371-75-5
nAChR agonist 1 is a brain-permeable and orally efficacious positive allosteric  α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.
NBTGR
T12191CAS 13153-27-0
NBTGR is a potent nucleoside transport inhibitor(adenosine uptake ,Ki of 70 nM).
Phenserine
T12446CAS 101246-66-6
Phenserine is a derivative of Physostigmine and is annoncompetitive, long-acting and selective inhibitor of AChE.
1-Naphthyl acetate
T19084CAS 830-81-9
1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the d...
RPR121056
T12766CAS 181467-56-1
RPR121056 is a Irinotecan metabolite, which is generated by CYP3A4. Irinotecan is an antineoplastic agent that inhibits topoisomerase type I.
A2B receptor antagonist 1
T10058CAS 531506-36-2
A2B receptor antagonist 1 (EXAMPLE 9B) is a potent A2B adenosine receptor antagonist extracted from patent WO 2009157938 A1.
Cyclodrine hydrochloride
T10914CAS 78853-39-1
Cyclone hydrochloride is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist.
Desformylflustrabromine hydrochloride
T11004CAS 951322-11-5
Desformylflustrabromine hydrochloride is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.
Acetamiprid
T14094CAS 135410-20-7
Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with ...
Agaric acid
T14140CAS 666-99-9
Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus...
Asoxime dichloride
T14333CAS 34433-31-3
Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride (HI-6) can be used...
CGS 15943
T14944CAS 104615-18-1
CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Re...
Cimetropium Bromide
T14966CAS 51598-60-8
Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.
(-)-(S)-B-973B
T17300CAS 2244989-34-0
(-)-(S)-B-973B is an effective allosteric agonist and a positive allosteric modulator of α7 nAChR.
Mivacurium chloride
T22371CAS 106861-44-3
Mivacurium chloride is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in...
α-Conotoxin MII
TP2063CAS 175735-93-0
α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expres...
SEN 12333
T23348CAS 874450-44-9
α7 nicotinic acetylcholine receptor (nAChR) agonist
Lucidadiol
TN4456CAS 252351-95-4
Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, it also possesses inhibitory activity against acetylcholinesterase...
Mangostanol
TN4492CAS 184587-72-2
Mangostanol is an acetylcholinesterase (AChE) selective inhibitor.Mangostanol has anti-cancer activity, it shows significant activities against the CEM-SS cell ...
Myrianthic acid
TN4600CAS 89786-84-5
Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low...
Niazimicin
TN4652CAS 147821-49-6
Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity i...
Pluviatolide
TN4812CAS 28115-68-6
(-)-Pluviatolide can inhibit electrically-induced and acetylcholine-induced contraction in the isolated guinea-pig ileum.
Pseudotaraxasterol
TN4837CAS 464-98-2
Pseudotaraxasterol shows cytotoxic activity against MOLT-4 cells.
Tubotaiwine
TN5193CAS 6711-69-9
Tubotaiwine shows selective activity against L. infantum. Tubotaiwine and apparicine have affinity for adenosine receptors in the micromolar range and also have...
A 582941
T22016CAS 848591-90-2
A 582941 is a Selective agonist of α7 nAChR partial
Isodunnianol
TN4286CAS 139726-30-0
Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from ...
Harmalol
T8770CAS 525-57-5
Harmalol is a bioactive beta-carboline and a member of the harmala alkaloids
A 582941 HCl (848591-90-2(free base))
T8725CAS T8725
A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
A 582941 HCl (848591-90-2(free base))
T8725CAS T8725
A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
Pirimiphos-methyl
T20539CAS 29232-93-7
Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms.Pirimiphos-methyl is often used f...
Clothianidin
T21153CAS 210880-92-5
Clothianidin, an insecticide, acts as an agonist of acetylcholine to stimulate nAChR, thereby activating post-synaptic acetylcholine receptors but not inhibitin...
Azamethiphos
T20812CAS 35575-96-3
Azamethiphos, an organothiophosphate insecticide, is used in Atlantic salmon fish farming to control parasites.
4BP-TQS
T8868CAS 360791-49-7
4BP-TQS is an allosteric agonist of α7 nAChRs.
JHU 37152
T9019CAS 2369979-67-7
JHU 37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 rec...
Leojaponin
TN4426CAS 864817-63-0
Leojaponin is a prolyl oligopeptidase (POP) inhibitor. Leojaponin exhibits significant cytoprotective activities against glutamate-induced toxicity at concentra...
Dipterocarpol
TN3875CAS 471-69-2
Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory ...
Tropisetron
T22448CAS 89565-68-4
Tropisetron is a α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
1,5-Diphenylpentan-1-one
TN2505CAS 39686-51-6
1,5-Diphenylpentan-1-one shows poor insecticidal and acetylcholinesterase inhibitory activities.
TA-03
T8585CAS 5778-80-3
TA-03 is a potent inhibitor of AChE in treatment of cognitive manifestation of AD.
2,3-Dihydrobenzofuran
Fr14127CAS 496-16-2
2,3-Dihydrobenzofuran is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara. Coumaran can be used as a biopesticide. 2,3-dihydrobenzof...
Lupinine
Fr16605CAS 486-70-4
Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Lo...
4-Hydroxycoumarin
PDK0015CAS 1076-38-6
4-Hydroxycoumarin, a coumarin derivative.4-Hydroxycoumarin serves as an immediate precursor of 4-hydroxycoumarin (4HC) type anticoagulants (for example, warfari...
6-beta-Hydroxyhyoscyamine
T21532CAS 55869-99-3
6-beta-Hydroxyhyoscyamine and 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine.
(-)-Anabasine
T7224CAS 494-52-0
Anabasine is a nicotine analog that is an alkaloid found in tree tobacco (Nicotiana glauca). Anabasine has been used as an industrial insecticide and, since it ...
Lobelin
TL0018CAS 90-69-7
Inhalation challenge with capsaicin and rapid intravenous injection of Lobelin and alinamin indicated that peripheral c-fiber receptors were involved in the ind...
1,5-Dihydroxyxanthone
TN2504CAS 14686-65-8
1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have an...
7-O-Methyleriodictyol
TN3243CAS 51857-11-5
7-O-Methyleriodictyol inhibits the maximum contractions induced by acetylcholine or oxytocin.
Dehydrovomifoliol
TN3812CAS 39763-33-2
Dehydrovomifoliol could be a marker of Polish heather honey. Dehydrovomifoliol exhibits moderate acetylcholinesterase (AChE) inhibitory activities. Dehydrovomif...
8-Hydroxypinoresinol
TN3285CAS 81426-17-7
8-Hydroxypinoresinol has antioxidant activity,it and phillygenin significantly reduce the cell injury by 3-morpholinosydnonimine (SIN-1), a ONOO- generator, may...
8-Lavandulylkaempferol
TN3287CAS 883859-83-4
8-Lavandulylkaempferol exhibits significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, re...
Alloisoimperatorin
TN3380CAS 35214-83-6
Alloisoimperatorin is a candidate of AChE inhibitors, it displays potent antioxidant effects against the DPPH radical and against renal epithelial cell injury b...
Atherosperminine
TN3466CAS 5531-98-6
Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong an...
beta-Amyrone
TN3500CAS 638-97-1
beta-Amyrone has antifungal activity, it also shows a moderate activity against Chikungunya virus replication (EC50 =86 uM). beta-Amyrone exhibits anti-α-gluco...
Buxbodine B
TN3550CAS 390362-51-3
Buxbodine B has weak anti-AChE activity with IC50 values in the range of 10.8-98μM.
Conodurine
TN3696CAS 2665-57-8
Conodurine shows leishmanicidal and antibacterial activities, it shows inhibition activity for acetyl (AChE) and butyrylcholinesterase (BuChE).
Cyclomorusin
TN3744CAS 62596-34-3
Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of ...
Metixene hydrochloride
T12020CAS 1553-34-0
Metixene hydrochloride is an anticholinergic antiparkinsonian agent.
Swertisin
TN2247CAS 6991-10-2
Swertisin, a novel herbal biomolecule, shows a strong antihyperglycemic action. Swertisin is an adenosine A1 receptor antagonist, is known to have antidiabetic,...
Varenicline
T4246CAS 866823-63-4
Varenicline is a Selective α4β2 nicotinic acetylcholine receptor partial agonist.
Dinotefuran
T7124CAS 165252-70-0
Dinotefuran is an insecticide of the neonicotinoid class for control of insect pests such as aphids, whiteflies, thrips, leafhoppers, leafminers. Its mechanism...
Umeclidinium bromide
T4997CAS 869113-09-7
Umeclidinium bromide is a novel mAChR antagonist.
Anisotropine Methylbromide
T4981CAS 80-50-2
Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.
Adenine hydrochloride hydrate
T5081CAS 6055-72-7
Adenine is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfect...
mAChr-in-1
T5476CAS 119391-56-9
mAChR-IN-1 is muscarinic cholinergic receptor(mAChR) antagonist (IC50=17 nM).
mAChR-IN-1 hydrochloride
T5655CAS 119391-73-0
mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm.
Dehydroevodiamine hydrochloride
T5721CAS 111664-82-5
Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitr...
Edrophonium chloride
T5855CAS 116-38-1
Edrophonium chloride is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specifi...
Proxyphylline
T5940CAS 603-00-9
Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and...
Imidafenacin
T4986CAS 170105-16-5
Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM.
Norarecoline hydrochloride
T5805CAS 6197-39-3
Norarecoline hydrochloride is a muscarinic agonist.
Encenicline
T7193CAS 550999-75-2
Encenicline is a selective α7 nicotinic acetylcholine receptor (nAChRs) agonist in development for treating cognitive impairment in schizophrenia and Alzheime...
GALANTHAMINONE
T7114CAS 510-77-0
Galanthaminone is a cholinesterase (AChE) inhibitor, is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
NECA
T7340CAS 35920-39-9
NECA is an agonist of Adenosine receptor, increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier mo...
Revefenacin
T7392CAS 864750-70-9
Revefenacin is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.
Piperidolate hydrochloride
T7555CAS 129-77-1
Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylchol...
4-Methylbenzylidene camphor
T7465CAS 36861-47-9
4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations ,specifically UV B radiation, also has estrogenic activ...
Benzetimide hydrochloride
T7561CAS 5633-14-7
Benzetimide hydrochloride is an antagonist of muscarinic acetylcholine receptor.treatment neuroleptic-induced parkinsonism.
VASICINE
T4960CAS 6159-55-3
Vasicine is oxytocic and abortifacient agents.Vasicine, a potential natural cholinesterase inhibitor, has been in development for treatment of Alzheimer's disea...
MC-Val-Cit-PAB
T5149CAS 159857-80-4
MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this link...
Coluracetam
T7591CAS 135463-81-9
Coluracetam(MKC-231) is a Choline Uptake Enhancer.
Gnetol
T7052CAS 86361-55-9
Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly su...
Pitofenone hydrochloride
T4466CAS 1248-42-6
Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 3...
Huperzine B
T2S1720CAS 103548-82-9
1. Huperzine-B is a efficient inhibitor of human brain AChE. 2. Huperzine-B can enhance ognitive and protect neuro, may be potentially new drug candidates for A...
Donepezil
T7041CAS 120014-06-4
Donepezil is a piperidine-based, potent, specific, and reversible inhibitor of acetylcholinesterase (AChE). It can be used for the treatment of mild to moderate...
(+)-Corynoline
T6S2356CAS 18797-79-0
1. Corynoline is an acetylcholinesterase inhibitor.
Choline glycerophosphate
T4439CAS 28319-77-9
Glycerylphosphorylcholine is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have ...
Palmatine
T5S0802CAS 3486-67-7
1. Palmatine is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has be...
beta-Eudesmol
T3865CAS 473-15-4
β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, incl...
Scopolamine
T3S0478CAS 51-34-3
1. Scopolamine, a nonselective muscarinic receptor antagonist, induces distinct behaviors of attenuated motility and C-like hyperactivity. 2. Scopolamine can in...
Isopropamide Iodide
T5051CAS 71-81-8
Isopropamide iodide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders. It also acts as a ...
Epiberberine
T5S2361CAS 6873-09-2
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1...
Hyoscyamine sulfate hydrate
T4S1619CAS 620-61-1
Hyoscyamine Sulfate is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus ni...
Aloenin A
T2S1181CAS 38412-46-3
1. Aloenin and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.
Hupehenine
T4S0111CAS 98243-57-3
Hupehenine is a steriodal alkaloid extracted from the bulbs of Fritillaria Hupehensis, with the potential for inhibiting acetylcholine, antagonism for muscarini...
kuwanon G
T3S1612CAS 75629-19-5
1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment fo...
Picfeltarraenin IA
T5S1025CAS 97230-47-2
1. Picfeltarraenin IA, IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.
ABT-702 dihydrochloride
T4668CAS 1188890-28-9
ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor.
Polygalacic acid
T3767CAS 22338-71-2
Polygalacic acid(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increases choline ace...
CCMI
T7422CAS 917837-54-8
CCMI is a potent and selective modulator of α7 nAChR-positive allosteric.
2-Chloroadenosine
T7736CAS 146-77-0
2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors( Ki:300, 80, and 1,900 nM, respectively...
Questin
TN2131CAS 3774-64-9
Questin has promising inhibitory potential against AChE, BChE, and BACE1, it may be used in the development of therapeutic or preventive agents for Alzheimer's ...
Fustin
TN1653CAS 20725-03-5
Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
6-Ethoxydihydrosanguinarine
TN1305CAS 28342-31-6
6-Ethoxydihydrosanguinarine shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 valu...
Asimilobine
TN1409CAS 6871-21-2
(-)-Asimilobine shows antioxidative, anti-acetylcholinesterase (AChE), anti-α±-glucosidase, anti-leishmanial and anti-fungal activities; it displays weak inhi...
Cassiaside
TN1472CAS 123914-49-8
Cassiaside has significant hepato-protective effects against galactosamine damage, which is higher than that of silybin from Silybum marianum.
Corynoxidine
TN1527CAS 57906-85-1
Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains. It inhibits acetylcholinesterase activ...
D-Menthol
TN1544CAS 15356-60-2
D-Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in ...
Dehydrodicentrine
TN1559CAS 19843-03-9
Dehydrodicentrine showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 value of 2.98 μM.
Flavokawain C
TN1645CAS 56798-34-6
Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cyc...
Garcinone C
TN1673CAS 76996-27-5
Garcinone C is a potent inhibitor of AChE.
Neoeriocitrin
TN1124CAS 13241-32-2
Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is...
Hibifolin
TN1736CAS 55366-56-8
Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-am...
Isorosmanol
TN1798CAS 93780-80-4
Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions...
Isorubrofusarin 10-gentiobioside
TN1799CAS 200127-93-1
Isorubrofusarin 10-gentiobioside shows promising inhibitory activity against AChE/BACE1.
Kuwanon E
TN1848CAS 68401-05-8
Kuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acety...
Leptomerine
TN1858CAS 22048-97-1
Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity.
Lycoramine
TN1899CAS 21133-52-8
Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
Lycoramine
TN1899CAS 21133-52-8
Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
Picfeltarraenin X
TN2067CAS 1391826-61-1
Picfeltarraenin X shows stronger AChE inhibition than the known AChE inhibitor Tacrine.
3-Epioleanolic acid
TN1248CAS 25499-90-5
3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affect...
Dehydronuciferine
TN1091CAS 7630-74-2
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn. Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
Aldicarb sulfone
T7640CAS 1646-88-4
Aldicarb sulfone is a cholinesterase inhibitor .
EB-3D
T7955CAS 1839150-63-8
EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
PNU-282987 S enantiomer free base
T7695CAS 737727-12-7
PNU-282987 S enantiomer free base is an  agonist of α7 nicotinic acetylcholine receptor (α7 nAChR).
Piperidolate
T7405CAS 82-98-4
Piperidolate inhibits intestinal cramp induced by acetylcholine
A-867744
TQ0117CAS 1000279-69-5
A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).
Metixene hydrochloride hydrate
TQ0304CAS 7081-40-5
Metixene is an anticholinergic antiparkinsonian agent, potently inhibits the binding of quinuclidinyl to the muscarinic receptor in rat brain cortical tissue (I...
AVex-73
T7780CAS 195615-83-9
AVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
Thujone
T8193CAS 546-80-5
Thujone is an inhibitor of  ACh with an IC50 value of 24.7μM.
Galanthamine
T4S1725CAS 357-70-0
Galanthamine is an acetylcholinesterase (AChE)inhibitor(IC50 : 500 nM), can reduce brain damage induced by hypoxia-ischemia.
Epiberberine (chloride)
T8306CAS 889665-86-5
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.0...
NS 1738
T7884CAS 501684-93-1
NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs)
N-p-trans-Coumaroyltyramine
TN1030CAS 36417-86-4
N-p-trans-Coumaroyltyramine is a natural product, is an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits ...
α-MSH
T7813CAS 581-05-5
α-MSH is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
Syn-Ake acetate
T7895CAS 823202-99-9
Syn-Ake acetate is a muscarinic acetylcholine receptor antagonist.
Pachycarpine
T7853CAS 492-08-0
Pachycarpine is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent
VU0238429
T8007CAS 1160247-92-6
VU0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).
VU0119498
T8224CAS 79183-37-2
VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.
VU0238441
T8219CAS 85511-68-8
VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM.
Cyclopentolate Hydrochloride
T8383CAS 5870-29-1
Cyclopentolate Hydrochloride is a muscarinic acetylcholine receptors antagonist with Kis of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively.
BNC210
T8318CAS 13589-06-5
BNC210 is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression.
Mestinon
T0780CAS 101-26-8
Pyridostigmine bromide is a cholinesterase inhibitor with a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravi...