AChR

An acetylcholine receptor (abbreviated AChR) is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter.

Cat No.	product name
T2939	ForskolinHOT	Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
T8147	Solifenacin	Solifenacin (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively.
T0445	Promethazine	Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
T1328	DL-trihexyphenidyl hydrochloride	DL-trihexyphenidyl hydrochloride is a muscarinic antagonist.
T3126	Bethanechol chloride	Bethanechol chloride is a slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in th...
T0375L	Atropine sulfate monohydrate	Atropine sulfate monohydrate, the sulfate salt of atropine, is a competitive muscarinic acetylcholine receptor antagonist.
T2387	Glycopyrrolate	Glycopyrrolate is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anestheti...
T1083L	Theophylline monohydrate	Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
T1221	Acetylcholine chloride	Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride mimi...
T0052L	Strychnine Sulfate	In smaller doses, strychnine functions as a stimulant and an athletic performance-enhancer. The most common source is from the seeds of the Strychnos nux-vomica ...
T2181	Scopolamine N-oxide HBr	Scopolamine N-oxide HBr is an antagonist of the muscarinic acetylcholine.
T6684	Succinylcholine Chloride Dihydrate	Succinylcholine Chloride Dihydrate is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.
T0455	Clozapine	Clozapine is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays...
T0364L	Dibucaine hydrochloride	Dibucaine hydrochloride, a long-acting local amide anestheticsis, is usually used for surface anesthesia.
T0018	Procainamide hydrochloride	Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine...
T0113	Mebhydrolin napadisylate	Mebhydrolin (napadisylate) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
T1682	Methacholine Chloride	Methacholine chloride is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE a...
T0594	Diphemanil mesylate	Diphemanil methylsulfate, a quaternary ammonium anticholinergic, binds muscarinic acetylcholine receptors and thus decreases secretory excretion of stomach acids...
T0790	Carbaryl	Carbaryl is a carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhib...
T1760	TBPB	TBPB is an allosteric M1 mAChR agonist.
T1083	Theophylline	Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant act...
T0130	Physostigmine Salicylate	Physostigmine, a parasympathomimetic alkaloid, is a reversible cholinesterase inhibitor. It extracts from the Calabar bean.
T6397	Atracurium besylate	Atracurium besylate is a non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack...
T1341	Nortropine	Nortropine is used as muscarinic receptor antagonists.
T0375	Atropine	Atropine Sulfate is the sulfate salt of atropine, a naturally-occurring alkaloid isolated from the plant Atropa belladonna. Atropine functions as a sympathetic, ...
T0177	Homatropine Bromide	Homatropine Hydrobromide is the hydrobromide salt form of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. Homatropine, a competi...
T1612	Hodostin	Hodostin is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.
T0051	Urethane	Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T7002	Trihexyphenidyl hydrochloride	Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class.
T1236	Pentolinium Tartrate	A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.
T1199	Mitotan	Mitotane is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormone...
T0766	Promazine hydrochloride	Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatm...
T0818	Decamethonium bromide	Decamethonium Bromide is a neuromuscular blocker and nicotinic AChR partial agonist.
T6548	Irsogladine	Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
T1215	Nicardipine hydrochloride	Nicardipine Hydrochloride is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicar...
T0804	(+)-Pilocarpine hydrochloride	Pilocarpine hydrochloride, a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy.
T0713	Drofenine hydrochloride	Drofenine hydrochloride is an effective competitive inhibitor of BChE (Ki value: 3 uM).
T2285	EVP-6124 hydrochloride	EVP-6124 hydrochloride is a new-type partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
T0375L2	Atropine sulfate	Atropine sulfate is a competitive antagonist for muscarinic acetylcholine receptor.
T0287	Hexamethonium Bromide	Hexamethonium Bromide, a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross th...
T1049L	Oxybutynin	Oxybutynin is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.
T2571	Benactyzine hydrochloride	Benactyzine hydrochloride is a centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to invest...
T0103	Dipivefrin hydrochloride	Dipivefrin that is available as an ophthalmic solution is a prodrug of adrenaline, which is used to treat glaucoma.
T0720	Gallamine triethiodide	Gallamine Triethiodide, a synthetic inhibiting drug, is nondepolarizing.
T0074L	Chlorprothixene hydrochloride	Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a t...
T1484	Perindoprilat	Perindoprilat is an angiotensin-converting enzyme inhibitor.
T1229	Erdosteine	Erdosteine is a homocysteine-derived thiol derivative with mucolytic and free radical scavenging properties. Erdosteine and its metabolites modulate mucus produc...
T0364	Dibucaine	Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
T6721	Vinblastine	Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
T6575	LY2119620	LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.
T1327	Nortriptyline hydrochloride	Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, ...
T6115	Fostamatinib	Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
T2984	Scopoletin	Scopoletin is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE).
T2337	BMS303141	BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
T1459	Cisatracurium besylate	Cisatracurium Besylate is a nondepolarizing skeletal muscle relaxant for intravenous administration.
T0625	Theobromine	3, 7-Dimethylxanthine, a xanthine alkaloid, is used as a bronchodilator and as a vasodilator.
T2138	Oxyphencyclimine Hydrochloride	Oxyphencyclimine Hydrochloride is a synthetic tertiary amine and antimuscarinic agent with antispasmodic and antisecretory activities.
T4286	Fmoc-Val-Ala-PAB	Fmoc-Val-Ala-PAB is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RGD...
T4289	Mc-Val-Ala-PAB	Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC).
T7500	Isoxazole	Isoxazole is the inhibitor of acetylcholinesterase (AChE). The ligands of Isoxazole bind to and inhibit the Sxc- antiporter.
T4006	Pentostatin	Pentostatin is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).
T4246	Varenicline	Varenicline is a Selective α4β2 nicotinic acetylcholine receptor partial agonist.
T4466	Pitofenone hydrochloride	Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36...
T2S1720	Huperzine B	1. Huperzine-B is a efficient inhibitor of human brain AChE. 2. Huperzine-B can enhance ognitive and protect neuro, may be potentially new drug candidates for Al...
T3196	GNF7	GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.
T2141	Mecamylamine hydrochloride	Mecamylamine hydrochloride is a nicotinic antagonist, used as a ganglionic blocker in hypertension.
T0802	Procaine hydrochloride	Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine ...
T0064	Adenine	Adenine, a purine derivative, is a nucleobase with various roles in biochemistry including cellular respiration, in the form of both the energy-rich ATP and NAD ...
T2182	Scopolamine HBr trihydrate	Scopolamine hydrobromide is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like A...
T0098	Ipratropium bromide monohydrate	Ipratropium bromide is a muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for ...
T1039	Choline chloride	Choline chloride is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl ...
T1460	Dicyclomine hydrochloride	Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.
T1072	Loxeen	Pridinol Methanesulfonate Salt is used as an anticholinergic and as an antiparkinsonian agent.
T0665	2,6-Dihydroxypurine	Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme. Xanthin...
T3023	Catharanthine sulfate	Catharanthine inhibits nicotinic receptor-mediated diaphragm contractions.
T1069	Metoclopramide hydrochloride	Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic.
T3819	Acetylursolic acid	Acetylursolic acid has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities...
T1446	Bambuterol hydrochloride	Bambuterol, a long-acting beta-adrenoceptor agonist, is utilized for the treating of asthma.
T0765	4-Methylpyrazole	Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase...
T0794	Mepenzolate Bromide	Mepenzolate Bromide is a muscarinic antagonist used to treat gastrointestinal conditions.
T1575	Nizatidine	Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
T2319	Acotiamide hydrochloride	Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the ex...
T1636	Paroxetine hydrochloride	Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression.
T0296	Pempidine	Pempidine is a nicotinic antagonist, has been used as a ganglionic blocker in the treatment of hypertension.
T0269	Dichlorisone Acetate	Dichlorisone Acetate is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
T0427	Homatropine Methylbromide	Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.
T1111	Pralidoxime Chloride	Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by acetylcholinesterase or organophosphates inhibitors (nerve age...
T1594	Vecuronium bromide	Vecuronium is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity.
T6S2356	(+)-Corynoline	1. Corynoline is an acetylcholinesterase inhibitor.
T1668	Vinblastine sulfate	Vinblastine sulfate can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
T1628	Rivastigmine tartrate	Rivastigmine tartrate is a carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment o...
T6426	Buclizine HCl	Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Bu...
T1567	Olanzapine	Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
T1534	Darifenacin HBr	Darifenacin is a selective muscarinic receptor antagonist used to treat urinary incontinence and overactive bladder syndrome.
T0731	N,N-Diethyl-m-toluamide	DEET is the most general active composition in insect repellents.
T0268	Lobeline hydrochloride	Lobeline hydrochloride is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes.
T1179	Tiotropium bromide	Tiotropium is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a musc...
T6707	Tiotropium Bromide hydrate	Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a musc...
T0851	Pregnenolone	Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
T3791	Atractyloside A	Atractyloside is a glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEP...
T1231	Pilocarpine nitrate	Pilocarpine nitrate is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
T2183	Scopolamine butylbromide	Scopolamine butylbromide is a competitive antagonist of mAChR (IC50: 55.3 ± 4.3 nM).
T6607	Nitenpyram	Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.
T1049	Oxybutynin hydrochloride	Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, and M3 subtypes of the mus...
T1281	Tropicamide	Tropicamide is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide b...
T2390	Cevimeline hydrochloride hemihydrate	Cevimeline hydrochloride hemihydrate is a novel muscarinic receptor agonist, used as a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
T0166	Pancuronium bromide	Pancuronium dibromide, a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide blocking neuromuscular transmissi...
T0253	Methscopolamine	Methscopolamine (Pamine), as a natural plant alkaloid, is a muscarinic acetylcholine receptor blocker.
T0185	Escitalopram	Escitalopram is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol upta...
T0024	Primidone	Primidone is an anticonvulsant of the pyrimidinedione class.
T0716	Molindone hydrochloride	Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.
T2725	Scopolamine HBr	Scopolamine hydrobromide is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like A...
T0962	L-Hyoscyamine	L-Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on...
T3026	(-)-Huperzine A	Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibit...
T0172	Maprotiline hydrochloride	Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, in...
T1472	Trospium chloride	Trospium is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. Trospium has not been implicated in ca...
T0302	Triflupromazine hydrochloride	Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
T0162	Quetiapin	Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapin...
T3619	VU 0357017 hydrochloride	VU 0357017 hydrochloride is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.37 ± 0.15).
T0976	Propoxur	Propoxur is an insecticide used to control cockroaches, flies, mosquitoes, and lawn and turf insects. Acute (short-term) exposure of humans to propoxur by ingest...
T1624	Neostigmine bromide	Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and...
T0099	Tolterodine tartrate	Tolterodine Tartrate(PNU-200583E; Kabi-2234) is a potent antagonist for muscarinic receptor. It show selectivity for the urinary bladder and salivary glands in v...
T0156	Rocuronium bromide	Rocuronium is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotr...
T6478	Donepezil HCl	Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
T0401	Benzethonium chloride	Benzethonium is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.
T1552	Itopride hydrochloride	Itopride hydrochloride is an AChE and D2DR inhibitor.
T1540	Doxepin hydrochloride	Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mech...
T0229	Rivastigmine	Rivastigmine is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.
T2422	PNU 282987	PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM...
T1220	Ethidium bromide	A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful p...
T2663	GTS 21 dihydrochloride	GTS 21 dihydrochloride is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.
T3503	MC-Val-Cit-PABC-PNP	MC-Val-Cit-PAB-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts t...
T1266	Terfenadine	Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistamin...
T6618	Orphenadrine Citrate	Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
T3993	BQCA	BQCA a highly selective allosteric modulator of the M1 mAChR.
T0786	Clidinium bromide	Clidinium, a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effect...
T0684	Ribavirin	Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T0703	Flavoxate hydrochloride	Flavoxate Hydrochloride(DW-61 Hydrochloride), a muscarinic AChR antagonist, is used in the therapy of various urinary syndromes and as an antispasmodic.
T1320	Disopyramide	A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) wi...
T1657	Varenicline Tartrate	Varenicline tartrate is a benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist. It is used for SMOKING CESSATION.
T0236	Azatadine Maleate	Azatadine dimaleate is an inhibitor for histamine（IC50=6.5 nM） and cholinergic（IC50=10 nM）.
T2558	Cladribine	Cladribine, an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.
T3324	Lycorine	Lycorine inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
T0862	Diphenidol hydrochloride	Diphenidol hydrochloride, a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.
T2845	Imperatorin	Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T2846	Isoimperatorin	Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).
T0479	Cytisine	Cytisine, an alkaloid, is found naturally in several plants.
T1202	(-)-Cotinine	Cotinine is an alkaloid found in tobacco and is also the predominant metabolite of nicotine.
T3872	Nodakenin	Nodakenin is a compound with anti-allergic and anti-inflammatory activities.
T6950	PNU120596	PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.
T1006	Propantheline bromide	Propantheline bromide competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine glan...
T0072	Adiphenine hydrochloride	Adiphenine hydrochloride, a nicotinic receptor inhibitor, can be used as an antispasmodic drug.
T0997	Temephos	Temefos is a cholinesterase inhibitor. Temefos is an organothiophosphate insecticide, used in the therapy of water infested with disease-carrying insects includi...
T2555	Aclidinium bromide	Aclidinium is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis or emphysema. Aclidiniu...
T0944	Levamisole hydrochloride	Levamisole hydrochloride is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by ...
T6364	Desfesoterodine	5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.
T0999	Clevidipine butyrate	Clevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when o...
T6009	TAPI1	TAPI-1, an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors.
T2172	SQ 22536	SQ 22536, the adenosine analogue 9-(Tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (Ictalurus melas...
T2759	Loganin	Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent...
T0086	Galanthamine HBr	Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
T3694	Tebanicline	Tebanicline (ABT-594, Ebanicline) acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. Te...
T3720	Tebanicline hydrochloride	Tebanicline (ABT-594, Ebanicline), is an effective synthetic nicotinic (non-opioid) analgesic drug.
T2191	Tacrine hydrochloride hydrate	Tacrine hydrochloride hydrate is a cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxant...
T6547	Ipratropium Bromide	Ipratropium is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema.
T6744	Methylbenactyzine Bromide	Dimethadione is an anticonvulsant that is the active metabolite of trimethadione.
T0464	Carbetapentane citrate	Pentoxyverine Citrate, an antitussive (cough suppressant), is frequently used for a cough related to illnesses like the common cold.
T0111	Solifenacin succinate	Solifenacin succinate is a quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treat...
T6745	5-Iodotubercidin	5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphoryl...
T2782	Catharanthine	Catharanthine suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).
T0338	Minaprine	Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T1474	Otilonium bromide	Otilonium Bromide, an antimuscarinic, is utilized as a spasmolytic agent.
T1475	Fesoterodine fumarate	Fesoterodine Fumarate is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic prop...
T1542	Pirenzepine dihydrochloride	Pirenzepine dihydrochloride is a selective M1 muscarinic receptor antagonist, inhibiting gastric secretion.
T2198	Arecoline HBr	Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist.
T7041	Donepezil	Donepezil is a piperidine-based, potent, specific, and reversible inhibitor of acetylcholinesterase (AChE). It can be used for the treatment of mild to moderate ...
T4439	Choline glycerophosphate	Glycerylphosphorylcholine is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a...
T21519	2-Chloro-N6-cyclopentyladenosine	2-Chloro-N6-cyclopentyladenosine is a potent and selective agonist of adenosine A1 receptor
T8552	PSEM 89S TFA	PSEM 89S TFA is a brain-penetrant and selective ion channels agonist, and is orthogonally selective for Q79G and L141F, respectively.
T13301	Violanthin	Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antioxi...
T15655	KFM19	KFM19 is an effective and selective antagonist of the Adenosine receptor (A1-receptor) (IC50: 50 nM).
T13373	YM17E	YM17E is an acyl CoA:cholesterol acyltransferase (ACAT) inhibitor(IC50 of 44 nM in rabbit liver microsomes in vitro).
T19623	α-Muricholic acid	α-Muricholic acid is the most abundant primary bile acid in rodents.
T15942	MK-7622	MK-7622 is a modulator of muscarinic M1 receptor positive allosteric.
T16353	Meseclazone	Meseclazone has anti-inflammatory, analgesic, and antipyretic activity. Meseclazone shows inhibitory potency of secondary phase ADP aggregation.
T16417	Oxitropium Bromide	Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary dise...
T16563	Pozanicline	Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozani...
T16980	Taminadenant	Taminadenant is an adenosine receptor antagonist.
T13713	GP531	GP531 is a second-generation adenosine regulating agent. It is pharmacologically silent under basal conditions but increases localized endogenous adenosine duri...
T17238	VU0152100	VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM).
T17300	(-)-(S)-B-973B	(-)-(S)-B-973B is an effective allosteric agonist and a positive allosteric modulator of α7 nAChR.
T17312	(+)-Phenserine	(+)-Phenserine is a novel selective inhibitor of cholinesterase non-competitive (IC50: 45.3 μM).
T22371	Mivacurium chloride	Mivacurium chloride is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in ...
T22448	Tropisetron	Tropisetron is a α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
T8585	TA-03	TA-03 is a potent inhibitor of AChE in treatment of cognitive manifestation of AD.
Fr14127	2,3-Dihydrobenzofuran	2,3-Dihydrobenzofuran is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara. Coumaran can be used as a biopesticide. 2,3-dihydrobenzofu...
Fr16605	Lupinine	Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Lor...
T13256	UP202-56	UP202-56 is an adenosinergic agonist and is an adenosine analog.
T10731	CDD0102	CDD0102 is a potent agonist of M1 Muscarinic receptor.
T21532	6-beta-Hydroxyhyoscyamine	6-beta-Hydroxyhyoscyamine and 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine.
T12653	(Rac)-ABT-202 dihydrochloride	(Rac)-ABT-202 dihydrochloride is a racemate of ABT-202. ABT-202 is an nicotinic acetylcholine receptors (nAChRs) agonist and can be used as an analgesic.
T19084	1-Naphthyl acetate	1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the de...
T10058	A2B receptor antagonist 1	A2B receptor antagonist 1 (EXAMPLE 9B) is a potent A2B adenosine receptor antagonist extracted from patent WO 2009157938 A1.
T10914	Cyclodrine hydrochloride	Cyclone hydrochloride is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist.
T11004	Desformylflustrabromine hydrochloride	Desformylflustrabromine hydrochloride is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.
T14094	Acetamiprid	Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with n...
T14140	Agaric acid	Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus ...
T14333	Asoxime dichloride	Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride (HI-6) can be used ...
T14345	Atropine methyl bromide	Atropine methyl bromide, a muscarinic receptor (mAChR) antagonist. Which is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil duri...
T14944	CGS 15943	CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Rec...
T11366	Garcinol	Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and ant...
T14966	Cimetropium Bromide	Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.
T12766	RPR121056	RPR121056 is a Irinotecan metabolite, which is generated by CYP3A4. Irinotecan is an antineoplastic agent that inhibits topoisomerase type I.
T12825	Timepidium bromide	Timepidium bromide is an agent of anticholinergic.
T12868	Sch412348	Sch412348 is a potent competitive the human adenosine A2A receptor antagonist with Ki of 0.6 nM and has >1000-fold selectivity over all other adenosine receptors...
T13066	TAK-071	TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).
T13129	Terodiline hydrochloride	Terodiline hydrochloride is an antagonist of M1-selective muscarinic receptor (mAChR)(Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bl...
T13681	Epi-galantamine	Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine inhibits AChE with an EC50 of 45...
T11351	Galanthamine N-Oxide	Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC50 of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate acco...
PDK0015	4-Hydroxycoumarin	4-Hydroxycoumarin, a coumarin derivative.4-Hydroxycoumarin serves as an immediate precursor of 4-hydroxycoumarin (4HC) type anticoagulants (for example, warfarin...
T7224	(-)-Anabasine	Anabasine is a nicotine analog that is an alkaloid found in tree tobacco (Nicotiana glauca). Anabasine has been used as an industrial insecticide and, since it i...
T12446	Phenserine	Phenserine is a derivative of Physostigmine and is annoncompetitive, long-acting and selective inhibitor of AChE.
T20539	Pirimiphos-methyl	Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms.Pirimiphos-methyl is often used fo...
T23146	PHA 568487	The quinuclidine PHA 568487 is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the cor...
T23348	SEN 12333	α7 nicotinic acetylcholine receptor (nAChR) agonist
T23469	TQS	TQS is a positive allosteric modulator of α7 nACh receptors.
T23524	W-84 dibromide	W-84 dibromide is a M2-receptor selective modulator.
T22016	A 582941	A 582941 is a Selective agonist of α7 nAChR partial
T8770	Harmalol	Harmalol is a bioactive beta-carboline and a member of the harmala alkaloids
T8725	A 582941 HCl (848591-90-2(free base))	A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
T8725	A 582941 HCl (848591-90-2(free base))	A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
T21153	Clothianidin	Clothianidin, an insecticide, acts as an agonist of acetylcholine to stimulate nAChR, thereby activating post-synaptic acetylcholine receptors but not inhibiting...
TN4837	Pseudotaraxasterol	Pseudotaraxasterol shows cytotoxic activity against MOLT-4 cells.
T21439	Tacrine	Tacrine is an indirect cholinergic agonist and centrally acting anticholinesterase. It is approved for the treatment of Alzheimer's disease.
T20812	Azamethiphos	Azamethiphos, an organothiophosphate insecticide, is used in Atlantic salmon fish farming to control parasites.
T8868	4BP-TQS	4BP-TQS is an allosteric agonist of α7 nAChRs.
T9019	JHU 37152	JHU 37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 rece...
T9018	JHU 37160	JHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 rece...
T21825	TAE-1	TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
T27076	8-Cyclopentyl-1,3-dimethylxanthine	8-Cyclopentyl-1,3-dimethylxanthine is a potent antagonist of adenosine A1 receptor.
T29123	VU0152099	VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).
TN5193	Tubotaiwine	Tubotaiwine shows selective activity against L. infantum. Tubotaiwine and apparicine have affinity for adenosine receptors in the micromolar range and also have ...
TN4812	Pluviatolide	(-)-Pluviatolide can inhibit electrically-induced and acetylcholine-induced contraction in the isolated guinea-pig ileum.
TL0018	Lobelin	Inhalation challenge with capsaicin and rapid intravenous injection of Lobelin and alinamin indicated that peripheral c-fiber receptors were involved in the indu...
TN3550	Buxbodine B	Buxbodine B has weak anti-AChE activity with IC50 values in the range of 10.8-98μM.
TN2504	1,5-Dihydroxyxanthone	1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have ant...
TN2505	1,5-Diphenylpentan-1-one	1,5-Diphenylpentan-1-one shows poor insecticidal and acetylcholinesterase inhibitory activities.
TN3243	7-O-Methyleriodictyol	7-O-Methyleriodictyol inhibits the maximum contractions induced by acetylcholine or oxytocin.
TN3285	8-Hydroxypinoresinol	8-Hydroxypinoresinol has antioxidant activity,it and phillygenin significantly reduce the cell injury by 3-morpholinosydnonimine (SIN-1), a ONOO- generator, may ...
TN3287	8-Lavandulylkaempferol	8-Lavandulylkaempferol exhibits significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, res...
TN3380	Alloisoimperatorin	Alloisoimperatorin is a candidate of AChE inhibitors, it displays potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by...
TN3466	Atherosperminine	Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong ant...
TN3500	Beta-Amyrone	beta-Amyrone has antifungal activity, it also shows a moderate activity against Chikungunya virus replication (EC50 =86 uM). beta-Amyrone exhibits anti-α-glucos...
TN3696	Conodurine	Conodurine shows leishmanicidal and antibacterial activities, it shows inhibition activity for acetyl (AChE) and butyrylcholinesterase (BuChE).
TN4652	Niazimicin	Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in...
TN3744	Cyclomorusin	Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of s...
TN3812	Dehydrovomifoliol	Dehydrovomifoliol could be a marker of Polish heather honey. Dehydrovomifoliol exhibits moderate acetylcholinesterase (AChE) inhibitory activities. Dehydrovomifo...
TN3875	Dipterocarpol	Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory a...
TN4286	Isodunnianol	Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0...
TN4426	Leojaponin	Leojaponin is a prolyl oligopeptidase (POP) inhibitor. Leojaponin exhibits significant cytoprotective activities against glutamate-induced toxicity at concentrat...
TN4456	Lucidadiol	Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, it also possesses inhibitory activity against acetylcholinesterase ...
TN4492	Mangostanol	Mangostanol is an acetylcholinesterase (AChE) selective inhibitor.Mangostanol has anti-cancer activity, it shows significant activities against the CEM-SS cell l...
TN4600	Myrianthic acid	Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-...
T12481	Pipecuronium bromide	Pipecuronium bromide is a powerful competitive antagonist of nAChR(Kd of 3.06 μM).
T12201	Nebracetam hydrochloride	Nebracetam hydrochloride is an agonist nootropic M1-muscarinic. Nebracetam hydrochloride induces a rise of intracellular Ca2+ concentration. Nebracetam hydrochlo...
T5S0802	Palmatine	1. Palmatine is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has bee...
T7465	4-Methylbenzylidene camphor	4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations ,specifically UV B radiation, also has estrogenic activi...
T7124	Dinotefuran	Dinotefuran is an insecticide of the neonicotinoid class for control of insect pests such as aphids, whiteflies, thrips, leafhoppers, leafminers. Its mechanism ...
T5940	Proxyphylline	Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and ...
T5805	Norarecoline hydrochloride	Norarecoline hydrochloride is a muscarinic agonist.
T7193	Encenicline	Encenicline is a selective α7 nicotinic acetylcholine receptor (nAChRs) agonist in development for treating cognitive impairment in schizophrenia and Alzheimer...
T7114	GALANTHAMINONE	Galanthaminone is a cholinesterase (AChE) inhibitor, is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
T7340	NECA	NECA is an agonist of Adenosine receptor, increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier mod...
T7392	Revefenacin	Revefenacin is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.
T7555	Piperidolate hydrochloride	Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylcholi...
T7561	Benzetimide hydrochloride	Benzetimide hydrochloride is an antagonist of muscarinic acetylcholine receptor.treatment neuroleptic-induced parkinsonism.
T5721	Dehydroevodiamine hydrochloride	Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitri...
T7422	CCMI	CCMI is a potent and selective modulator of α7 nAChR-positive allosteric.
T7591	Coluracetam	Coluracetam(MKC-231) is a Choline Uptake Enhancer.
T7736	2-Chloroadenosine	2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors( Ki:300, 80, and 1,900 nM, respectively)...
T7640	Aldicarb sulfone	Aldicarb sulfone is a cholinesterase inhibitor .
T7695	PNU-282987 S enantiomer free base	PNU-282987 S enantiomer free base is an agonist of α7 nicotinic acetylcholine receptor (α7 nAChR).
T7405	Piperidolate	Piperidolate inhibits intestinal cramp induced by acetylcholine
TQ0117	A-867744	A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).
TQ0304	Metixene hydrochloride hydrate	Metixene is an anticholinergic antiparkinsonian agent, potently inhibits the binding of quinuclidinyl to the muscarinic receptor in rat brain cortical tissue (IC...
T5855	Edrophonium chloride	Edrophonium chloride is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specific...
T5655	MAChR-IN-1 hydrochloride	mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm.
T8193	Thujone	Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T5S1025	Picfeltarraenin IA	1. Picfeltarraenin IA, IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.
T3865	Beta-Eudesmol	β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, inclu...
T7052	Gnetol	Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly sup...
T3S0478	Scopolamine	1. Scopolamine, a nonselective muscarinic receptor antagonist, induces distinct behaviors of attenuated motility and C-like hyperactivity. 2. Scopolamine can inc...
T5S2361	Epiberberine	1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
T4S1619	Hyoscyamine sulfate hydrate	Hyoscyamine Sulfate is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus nig...
T2S1181	Aloenin A	1. Aloenin and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.
T4S0111	Hupehenine	Hupehenine is a steriodal alkaloid extracted from the bulbs of Fritillaria Hupehensis, with the potential for inhibiting acetylcholine, antagonism for muscarinic...
T3S1612	Kuwanon G	1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for...
T4668	ABT-702 dihydrochloride	ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor.
T5476	MAChr-in-1	mAChR-IN-1 is muscarinic cholinergic receptor(mAChR) antagonist (IC50=17 nM).
T3767	Polygalacic acid	Polygalacic acid(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increases choline acet...
T5051	Isopropamide Iodide	Isopropamide iodide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders. It also acts as a m...
T5149	MC-Val-Cit-PAB	MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linke...
T4986	Imidafenacin	Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM.
T4960	VASICINE	Vasicine is oxytocic and abortifacient agents.Vasicine, a potential natural cholinesterase inhibitor, has been in development for treatment of Alzheimer's diseas...
T4997	Umeclidinium bromide	Umeclidinium bromide is a novel mAChR antagonist.
T4981	Anisotropine Methylbromide	Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.
T5081	Adenine hydrochloride hydrate	Adenine is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfecte...
T7780	AVex-73	AVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
T4S1725	Galanthamine	Galanthamine is an acetylcholinesterase (AChE)inhibitor(IC50 : 500 nM), can reduce brain damage induced by hypoxia-ischemia.
T12191	NBTGR	NBTGR is a potent nucleoside transport inhibitor(adenosine uptake ,Ki of 70 nM).
TN2130	Manghaslin	Manghaslin has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenolic-rich litchi pulp extracts. Manghaslin also s...
TN1736	Hibifolin	Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amy...
TN1798	Isorosmanol	Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions ...
TN1799	Isorubrofusarin 10-gentiobioside	Isorubrofusarin 10-gentiobioside shows promising inhibitory activity against AChE/BACE1.
TN1848	Kuwanon E	Kuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetyl...
TN1858	Leptomerine	Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity.
TN1899	Lycoramine	Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
TN1899	Lycoramine	Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
TN2067	Picfeltarraenin X	Picfeltarraenin X shows stronger AChE inhibition than the known AChE inhibitor Tacrine.
TN2131	Questin	Questin has promising inhibitory potential against AChE, BChE, and BACE1, it may be used in the development of therapeutic or preventive agents for Alzheimer's d...
TN1653	Fustin	Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
TN2247	Swertisin	Swertisin, a novel herbal biomolecule, shows a strong antihyperglycemic action. Swertisin is an adenosine A1 receptor antagonist, is known to have antidiabetic, ...
TP2063	α-Conotoxin MII	α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 express...
T12020	Metixene hydrochloride	Metixene hydrochloride is an anticholinergic antiparkinsonian agent.
T13772	MHP 133	MHP 133 is a drug with multiple CNS targets(AChE with Ki of 69 μM).
T12107	MRS-3777 hemioxalate	MRS-3777 hemioxalate is a selective antagonist of adenosine A3 receptor .
T12136	N-0861 racemate	N-0861 racemate is the racemate of N-0861.
T12159	APNEA	APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) is a potent and non-selective agonist of A3 adenosine receptor.
T12165	NAChR agonist 1	nAChR agonist 1 is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.
TN1673	Garcinone C	Garcinone C is a potent inhibitor of AChE.
TN1645	Flavokawain C	Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycl...
T8306	Epiberberine (chloride)	Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07...
T8383	Cyclopentolate Hydrochloride	Cyclopentolate Hydrochloride is a muscarinic acetylcholine receptors antagonist with Kis of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively.
T7955	EB-3D	EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
T7884	NS 1738	NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs)
T7813	α-MSH	α-MSH is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
T7895	Syn-Ake acetate	Syn-Ake acetate is a muscarinic acetylcholine receptor antagonist.
T7853	Pachycarpine	Pachycarpine is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent
T8007	VU0238429	VU0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).
T8224	VU0119498	VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.
T8219	VU0238441	VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM.
T8318	BNC210	BNC210 is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression.
TN1559	Dehydrodicentrine	Dehydrodicentrine showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 value of 2.98 μM.
TN1030	N-p-trans-Coumaroyltyramine	N-p-trans-Coumaroyltyramine is a natural product, is an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits a...
TN1091	Dehydronuciferine	Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn. Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
TN1124	Neoeriocitrin	Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is ...
TN1248	3-Epioleanolic acid	3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecti...
TN1305	6-Ethoxydihydrosanguinarine	6-Ethoxydihydrosanguinarine shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 value...
TN1409	Asimilobine	(-)-Asimilobine shows antioxidative, anti-acetylcholinesterase (AChE), anti-α±-glucosidase, anti-leishmanial and anti-fungal activities; it displays weak inhib...
TN1472	Cassiaside	Cassiaside has significant hepato-protective effects against galactosamine damage, which is higher than that of silybin from Silybum marianum.
TN1527	Corynoxidine	Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains. It inhibits acetylcholinesterase activi...
TN1544	D-Menthol	D-Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in t...
T0780	Mestinon	Pyridostigmine bromide is a cholinesterase inhibitor with a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis...