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Posatirelin

Name: Posatirelin
Brand: TargetMol
SKU: T34114
Price: 130 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T34114Cas No. 78664-73-0

Alias RGH-2202, Posatirelinum, BRN-6006446, BRN6006446, BRN 6006446

Posatirelin (BRN6006446) is a synthetic peptide with modulatory activity and neurotrophic effects on monoaminergic and cholinergic systems for the study of vascular dementia.

Posatirelin

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Purity: 99.95%

Catalog No. T34114Alias RGH-2202, Posatirelinum, BRN-6006446, BRN6006446, BRN 6006446Cas No. 78664-73-0

Posatirelin (BRN6006446) is a synthetic peptide with modulatory activity and neurotrophic effects on monoaminergic and cholinergic systems for the study of vascular dementia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$130	In Stock	In Stock
5 mg	$320	In Stock	In Stock
10 mg	$480	In Stock	In Stock
25 mg	$786	In Stock	In Stock
50 mg	$1,080	In Stock	In Stock
100 mg	$1,480	In Stock	In Stock
500 mg	$2,960	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.95%

ee:100%

Appearance:Solid

Color:White to Yellow

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COA CSFC HNMR ORP LCMS

Product Introduction

Bioactivity

Description	Posatirelin (BRN6006446) is a synthetic peptide with modulatory activity and neurotrophic effects on monoaminergic and cholinergic systems for the study of vascular dementia.
In vivo	The pharmacokinetics and endocrine effects of a therapeutic dose (10 mg/day) of posatirelin were investigated in healthy elderly subjects. Posatirelin was given once daily by intramuscular injection for 7 days. Pharmacokinetic parameters were estimated using a model-independent approach. The plasma concentrations of free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) and the circadian rhythms of prolactin and cortisol were considered as indicators variables of endocrine response to posatirelin administration. Posatirelin was well tolerated and no significant adverse effects were observed during the study. There were no significant changes in these parameters after multiple-dose administration (day 7). Posatirelin induced a progressive reduction in basal TSH levels and maximum response. There were no significant changes during treatment in the time at which basal levels of FT3 and FT4 occurred, and these levels remained within the normal range throughout the study. The circadian rhythms of cortisol and prolactin were not influenced by posatirelin treatment. The pharmacokinetics of posatirelin were not time-dependent, and the drug did not accumulate after multiple-dose administration. Short-term treatment with posatirelin did not induce clinically relevant endocrine consequences in healthy elderly subjects.[1]
Synonyms	RGH-2202, Posatirelinum, BRN-6006446, BRN6006446, BRN 6006446

Chemical Properties

Molecular Weight	352.43
Formula	C₁₇H₂₈N₄O₄
Cas No.	78664-73-0
Smiles	C([C@@H](NC(=O)[C@H]1NC(=O)CCC1)CC(C)C)(=O)N2[C@H](C(N)=O)CCC2
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (70.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8374 mL	14.1872 mL	28.3744 mL	141.8721 mL
5 mM	0.5675 mL	2.8374 mL	5.6749 mL	28.3744 mL
10 mM	0.2837 mL	1.4187 mL	2.8374 mL	14.1872 mL
20 mM	0.1419 mL	0.7094 mL	1.4187 mL	7.0936 mL
50 mM	0.0567 mL	0.2837 mL	0.5675 mL	2.8374 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc