broad

Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) is a broad range caspase inhibitor. Boc-Asp(OME)-Fluoromethyl Ketone inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.

Aprotinin (Traskolan) is a broad-spectrum serine protease (BPTI) inhibitor that inhibits the activity of a number of different esterases and proteases. Aprotinin is an antifibrinolytic agent used to minimize hemorrhage during complex surgical procedures.

Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases.Z-VAD-FMK binds to activated caspases and inhibits apoptosis.Z-VAD-FMK does not inhibit UCHL1 activity, even at concentrations up to 440 μM.

LL-37, Human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.

Milbemycin oxime is a broad spectrum antiparasitic, used as a veterinary drug.

Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 µM).

Cyclo-L-Trp-L-Trp is a broad-spectrum antifungal. It also induces a high degree of acetylation of histones.

Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.

Lactoferricin B (4-14), bovine (TFA), is a peptide derived from residues 4-14 of bovine lactoferrin, exhibiting broad-spectrum antimicrobial activity against various microorganisms[1].

SMAP-29 is a broad spectrum antibacterial and antifungal α-helical cathelicidin-derived peptide with strong potential as an antiinfective agent. It effectively permeabilizes bacterial membranes and induces significant alterations in the surface morphology of susceptible microorganisms.

Human β-defensin-1 (HβD-1) is a cysteine-rich, cationic skin antimicrobial peptide (SAP) produced by epithelial surfaces, circulatory cells, and cells of the reproductive tract, exhibiting antimicrobial activity against a broad spectrum of sperm-related bacteria.

Defensin HNP-1, human acetate is an antimicrobial peptide and human α -defensin found mainly in neutrophils with broad-spectrum antimicrobial activity against bacteria and viruses, triggers NF-κB and IRF1 thereby increasing IFN-α, induces apoptosis in tumor cells, inhibits vascular endothelial cell function, mediates immunity to infections and more.

H-Asp(Obzl)-OtBu.HCl is an amino acid derivative with broad applications in life science research.

H-DL-Phe-OtBu.HCl is an amino acid derivative with a broad spectrum of applications in life science-related research.

Fmoc-D-Phe(4-F)-OH is an amino acid derivative with broad applications in life sciences research.

HLF1-11, derived from human lactoferrin, serves as a broad-spectrum antimicrobial agent. It not only inhibits human MPO (myeloperoxidase) activity but also influences GM-CSF (granulocyte-macrophage colony-stimulating factor)-driven monocyte differentiation into macrophages, thereby augmenting immune responses [1] [2].

Buforin II, a powerful antimicrobial peptide originating from Buforin I (a protein extracted from the Asian toad Bufo bufo gargarizans's stomach), exhibits broad-spectrum antimicrobial properties against both Gram-positive and Gram-negative bacteria [1].

Defensin HNP-1 Human TFA, a human neutrophil peptide (HNP), plays a role in the early development of atherosclerosis by contributing to endothelial cell dysfunction. Additionally, it has demonstrated broad-spectrum antimicrobial and anti-leishmanial effects [1] [2].

Epinecidin-1 TFA, a multifunctional antimicrobial peptide (AMP) derived from the Orange-spotted grouper (Epinephelus coioides), exhibits a broad spectrum of bioactivities including antibacterial, antifungal, antiviral, anti-tumor, and immunomodulatory properties. It represents a promising alternative to conventional antibiotics [1].

Compound 8C (c[Arg-Arg-Arg-Arg-Dip-Dip-Dip]) demonstrates broad-spectrum efficacy against drug-resistant Gram-positive and Gram-negative bacteria. Specifically, it exhibits minimum inhibitory concentrations (MICs) of 3.1 μg mL for MRSA (ATCC BAA-1556), 3.1 μg mL for S. aureus (ATCC 29213), 12.5 μg mL for P. aeruginosa (ATCC 27883), and 12.5 μg mL for E. coli (ATCC 25922) [1].

Compound 9C [c[Arg-Arg-Arg-Arg-Nal-Nal-Nal]] demonstrates broad-spectrum efficacy against drug-resistant Gram-positive and Gram-negative bacteria. It exhibits minimum inhibitory concentrations (MICs) of 3.1 μg mL for MRSA (ATCC BAA-1556), 3.1 μg mL for S. aureus (ATCC 29213), 12.5 μg mL for P. aeruginosa (ATCC 27883), and 25 μg mL for E. coli (ATCC 25922) [1].

Tet-213, an antimicrobial peptide, exhibits broad-spectrum antibacterial activity and has been shown to promote repair of infected wounds [1].

Tet-213 TFA, an antimicrobial peptide, exhibits broad-spectrum antibacterial activity and promotes the repair of infected wounds [1].

SARS-CoV-2-IN-34 (S-20-1) is a broad-spectrum pan-coronavirus (CoV) fusion inhibitor that penetrates the blood-brain barrier and exhibits extensive inhibitory activity against both pseudotyped and authentic SARS-CoV-2, as well as pseudotyped variants of concern (VOCs). It shows high affinity for the receptor-binding domain (RBD) in the S1 and the heptad repeat 1 (HR1) domain in the S2 of the SARS-CoV-2 spike (S) protein, making it a valuable tool for infection research [1].