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Olamufloxacin
(Synonyms: HSR-903) Copy Product Info
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Synonyms: HSR-903
Catalog No. T218985 Copy Product Info
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Olamufloxacin (HSR-903) is an orally active fluoroquinolone antibacterial agent. It exhibits broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Olamufloxacin can inhibit the growth of extracellular Legionella spp. bacteria and the intracellular growth of Legionella pneumophila. It reduces cytotoxicity caused by intracellular proliferation of Legionella pneumophila and increases the survival rate of guinea pigs infected with this bacterium, while also decreasing the bacterial load in their lungs. Olamufloxacin is used in the study of Legionnaires' disease.
Olamufloxacin
Cas No. 167887-97-0
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Olamufloxacin (HSR-903) is an orally active fluoroquinolone antibacterial agent. It exhibits broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Olamufloxacin can inhibit the growth of extracellular Legionella spp. bacteria and the intracellular growth of Legionella pneumophila. It reduces cytotoxicity caused by intracellular proliferation of Legionella pneumophila and increases the survival rate of guinea pigs infected with this bacterium, while also decreasing the bacterial load in their lungs. Olamufloxacin is used in the study of Legionnaires' disease. |
| In vitro | Olamufloxacin (2 days) exhibits potent in vitro inhibition of the growth of 81 Legionella spp. strains, with an MIC50 of 0.008 mg/L, MIC80 and MIC90 of 0.032 mg/L, and a geometric mean MIC of 0.0244 mg/L. Olamufloxacin (0.008-0.032 mg/L; 3 days) suppresses the intracellular growth of Legionella pneumophila SG1 80-045 in J774.1 macrophages. Additionally, olamufloxacin (0.004 mg/L; 72 h) inhibits the cytopathic effect of intracellular Legionella pneumophila SG1 80-045 on J774.1 macrophages. |
| In vivo | Olamufloxacin (1.25-5 mg/kg; oral; twice daily; 2-7 days) enhances survival rates and reduces lung bacterial load in guinea pigs infected with Legionella pneumophila. |
| Synonyms | HSR-903 |
| Molecular Weight | 386.42 |
| Formula | C20H23FN4O3 |
| Cas No. | 167887-97-0 |
| Smiles | N[C@H]1C2(CN(C1)C=3C(C)=C4N(C=C(C(O)=O)C(=O)C4=C(N)C3F)C5CC5)CC2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Olamufloxacin in vivo | Olamufloxacin in vitro | Olamufloxacin formula | Olamufloxacin molecular weight
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