NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
TN3839	Desoxo-narchinol A	53859-06-6	98%
TN3839	Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TN2539	1beta-Hydroxyalantolactone	68776-47-6	98%
TN2539	1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD.
TMA1777	Hydrangenol 8-O-glucoside	67600-94-6	98%
TMA1777	Hydrangenol 8-O-glucoside may have anti-inflammary activity.
TN2095	Pomiferin	572-03-2	98%
TN2095	Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
TN1806	Isotetrandrine	477-57-6	98%
TN1806	Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
TN3708	Coronarin D	119188-37-3	98%
TN3708	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
T13625	Coronalolic acid	268214-52-4	98%
T13625	Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.
TN2775	2-Methoxystypandrone	85122-21-0	98%
TN2775	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflamm...
TN3397	Alpinumisoflavone	34086-50-5	98%
TN3397	Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
TN4263	Isoangustone A	129280-34-8	98%
TN4263	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
TN4785	Picrasidine I	100234-59-1	98%
TN4785	Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-ÎºB and ROS generation followed by suppressing the gene ...
TN2075	Pimaric acid	127-27-5	98%
TN2075	Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human ...
TN5011	Shizukaol B	142279-40-1	98%
TN5011	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
TN4162	Goshonoside F5	90851-28-8	98%
TN4162	Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN1359	Aflatoxin G1	1165-39-5	98%
TN1359	Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce l...
TN4604	Myricanone	32492-74-3	98%
TN4604	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
TN4094	Gallocatechin gallate	5127-64-0	98%
TN4094	Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
TN4489	Manassantin A	88497-87-4	98%
TN4489	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN2327	Zedoarondiol	98644-24-7	98%
TN2327	Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs...
TN4956	Scandoside	18842-99-4	98%
TN4956	Scandoside exerts anti-inflammatory effect via suppressing NF-ÎºB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidation...