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ZM600
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Catalog No. T89329
ZM600 is an effective and orally active anti-hepatic fibrosis agent that can reduce the protein expression of collagen I, α-SM, and p-p65. This compound shows promising potential for use in hepatic fibrosis research.
ZM600
ZM600
😃Good
Catalog No. T89329
ZM600 is an effective and orally active anti-hepatic fibrosis agent that can reduce the protein expression of collagen I, α-SM, and p-p65. This compound shows promising potential for use in hepatic fibrosis research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | ZM600 is an effective and orally active anti-hepatic fibrosis agent that can reduce the protein expression of collagen I, α-SM, and p-p65. This compound shows promising potential for use in hepatic fibrosis research. |
| In vitro | ZM600 exhibits cytotoxic effects on LX-2 cells with an IC50 value of 38.17 µM. ZM600 (0, 5, 10, 20 µM; 2+48 h) reduces the protein and mRNA expression of collagen I and α-SM induced by LPS and TGF-β1. Additionally, ZM600 (0, 5, 10, 20 µM; 2+2 h) diminishes the expression of p-p65, p-Smad2/3, and p-AKT proteins in LX-2 cells triggered by LPS and TGF-β1. |
| In vivo | ZM600, administered orally at doses of 15 and 30 mg/kg daily for a period of three weeks, was found to alleviate CCl4-induced experimental liver fibrosis. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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