Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • PI3K
    (326)
  • Apoptosis
    (99)
  • mTOR
    (79)
  • Akt
    (63)
  • Autophagy
    (60)
  • DNA-PK
    (30)
  • NF-κB
    (25)
  • ERK
    (11)
  • STAT
    (9)
  • Others
    (161)
Filter
Search Result
Results for "

pi3k

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    635
    TargetMol | Inhibitors_Agonists
  • Compound Libraries
    6
    TargetMol | Compound_Libraries
  • Peptide Products
    12
    TargetMol | Peptide_Products
  • PROTAC Products
    3
    TargetMol | PROTAC
  • Natural Products
    143
    TargetMol | Natural_Products
  • Recombinant Protein
    18
    TargetMol | Recombinant_Protein
  • Isotope Products
    4
    TargetMol | Isotope_Products
  • Antibody Products
    12
    TargetMol | Antibody_Products
  • Disease Modeling
    1
    TargetMol | Disease_Modeling_Products
  • Cell Research
    2
    TargetMol | Inhibitors_Agonists
PI3K/Akt/mTOR-IN-2
T605642757804-89-8In house
PI3K Akt mTOR-IN-2 is a potent PI3K AKT mTOR inhibitor with anticancer effects and selectivity for MDA-MB-231 cells (IC50 2.29 μM). It induces cell cycle arrest and apoptosis in cancer cells.
  • Inquiry Price
6-8 weeks
Size
QTY
LY294002
SF 1101, NSC 697286, LY 294002
T2008154447-36-6
LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5 0.57 0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
Quercetin
Sophoretin
T2174117-39-5
Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
Inavolisib
RG6114, GDC-0077
T153752060571-02-8
Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.It exerts its activity by binding to the ATP-binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
3-Methyladenine
NSC 66389, 3-MA
T18795142-23-4
3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50 = 60 μM) and class III VPS34 (IC50 = 25 μM). 3-Methyladenine inhibits autophagy.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
Alpelisib
BYL-719
T19211217486-61-7
Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity, inhibiting PI3Kβ γ δ with low activity (IC50=250 290 1200 nM). Alpelisib demonstrates antitumor activity and specifically targets PIK3CA mutant tumors.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
Taurocholic acid
N-Choloyltaurine
TN225981-24-3
Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholangiocyte damage via a PI3K-mediated pathway.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
Duvelisib
IPI-145, INK1197
T19881201438-56-3In house
Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ, with effects on p110δ (IC50 value is 0.0025 μM), p110γ (IC50 value is 0.274 μM), p110β (IC50 value is 0.85 μM) and p110α (IC50 value is 1.602 μM).
  • Inquiry Price
Size
QTY
Protectin D1
NPD1, Neuroprotectin D1
T37379660430-03-5In house
Protectin D1 (Neuroprotectin D1) is a neuroprotectin produced by neuronal cells and is a potential cardioprotective agent.Protectin D1 attenuates myocardial ischemia reperfusion injury and inhibits imiquimod-induced psoriasis-like skin inflammation by modulating the PI3K AKT signaling pathway.
  • Inquiry Price
10-14 weeks
Size
QTY
gsk2292767
T68501254036-66-2In house
GSK2292767 is a potent and selective inhibitor of PI3Kδ.
  • Inquiry Price
Inquiry
Size
QTY
PQR514
T700581927857-55-3In house
PQR514 is a potent PI3K inhibitor with anticancer activity and inhibits cancer cell proliferation.
  • Inquiry Price
6-8 weeks
Size
QTY
Safingol hydrochloride
SPC 100270 hydrochloride, L-threo-dihydrosphingosine hydrochloride
T83978139755-79-6In house
Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a specific inhibitor of protein kinase C. It induces autophagy in solid tumor cells and cancer cell death by inhibiting the PKC and PI3-kinase pathways.BIIB 722 Mesylate is a selective sodium-hydrogen exchange inhibitor. Safingol hydrochloride inhibits PKC and PI3k.
  • Inquiry Price
Size
QTY
Isoprenaline hydrochloride
NCI-c55630, Isoproterenol hydrochloride, Isoprenaline HCl
T105651-30-9
Isoprenaline hydrochloride (NCI-c55630) is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties.
  • Inquiry Price
Size
QTY
Idelalisib
GS-1101, CAL-101
T1894870281-82-6
Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM). The selectivity for p110δ is 40- to 300-fold than p110α β γ.
  • Inquiry Price
Size
QTY
CNX-1351
T22561276105-89-5
CNX-1351 is a potent, isoform-selective, and targeted covalent inhibitor of PI3Kα.
  • Inquiry Price
4-6 weeks
Size
QTY
Esculetin
Cichorigenin, Aesculetin
T2798305-01-1
Esculetin (Cichorigenin) is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs).
  • Inquiry Price
Size
QTY
1-Deoxynojirimycin
Moranoline, moranolin, Duvoglustat
T367519130-96-2
1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.
  • Inquiry Price
Size
QTY
SAR405
T12831L1523406-39-4
SAR-405 is a potent and selective PIK3C3 Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.
  • Inquiry Price
Size
QTY
buparlisib
NVP-BKM120, BKM120
T1827944396-07-0
Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52 166 116 nM for p110α, p110β, and p110δ).
  • Inquiry Price
Size
QTY
CZC24832
T19491159824-67-5
CZC24832 is a selective inhibitor of PI 3-kinase γ.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
Pictilisib
RG7321, GDC-0941
T1994957054-30-7
Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3 33 3 75 nM for p110α β δ γ).
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
Fimepinostat
PI3K HDAC Inhibitor, CUDC-907, CUDC 907
T20781339928-25-4
Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
Dactolisib
NVP-BEZ235, BEZ235
T2235915019-65-7
Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR, with IC50 values of 4 nM for p110α, 5 nM for p110γ, 7 nM for p110δ, 75 nM for p110β, and 20.7 nM for mTOR.
  • Inquiry Price
Size
QTY
as-605240
AS 605240
T2248648450-29-7
AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50 Ki: 87.8 nM).
  • Inquiry Price
Size
QTY