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Torbafylline

Catalog No. T67965 CAS 105102-21-4

Torbafylline, a xanthine derivative, is a phosphodiesterase (PDE) inhibitor that attenuates burn-induced protein hydrolysis in rat skeletal muscle through activation of the PDE4/cAMP/EPAC/PI3K/Akt pathway, and inhibits the enhanced ubiquitin-proteasome-dependent protein hydrolysis in skeletal muscle of cancer- and sepsis-prone rats.

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Torbafylline, CAS 105102-21-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 130.00
5 mg	In stock	$ 320.00
10 mg	In stock	$ 480.00
25 mg	In stock	$ 786.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,480.00
500 mg	In stock	$ 2,960.00
1 mL * 10 mM (in DMSO)	In stock	$ 331.00

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Purity: 99.21%

Biological Description

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Description

In vivo

Torbafylline (25 mg/kg per day; oral; three weeks) decreased fatigue to 68%. The blood flow in ligated muscles increased to a much smaller extent than in control muscles, and this smaller increase was attenuated by Torbafylline. A chronic decrease in the blood supply resulted in a significant shortening of the running time.[1]
Torbafylline (25 mg/kg p.o.; 2 times a day; 2 weeks) decrease in running time was reversed by chronic treatment of Torbafylline. This improved performance may be explained by a decreased accumulation of lactate in muscles with a limited blood supply due to the effect of Torbafylline to increase the release of lactate from ischaemic muscles.[1]

Molecular Weight	338.4
Formula	C16H26N4O4
CAS No.	105102-21-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (73.88 mM)

References and Literature

1. Okyayuz-Baklouti I. The effects of torbafylline on blood flow, pO2 and function of rat ischaemic skeletal muscle. Eur J Pharmacol. 1989;166(1):75-86. 2. Hudlicka O, et al. Effect of torbafylline on muscle blood flow, performance, and capillary supply in ischemic muscles subjected to varying levels of activity. Can J Physiol Pharmacol. 1994;72(7):811-817. 3. Joshi R, et al. Phosphodiesterase (PDE) inhibitor torbafylline (HWA 448) attenuates burn-induced rat skeletal muscle proteolysis through the PDE4/cAMP/EPAC/PI3K/Akt pathway. Mol Cell Endocrinol. 2014;393(1-2):152-16 4. Egginton S, et al. The effect of torbafylline on enzyme activities in fast and slow muscles with limited blood supply. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;99(1-2):163-168. 5. Lucas-Héron B, et al. Effect of torbafylline on mitochondrial calmitine in mouse skeletal muscle regeneration after injection of a myotoxic drug. J Neurol Sci. 1993;118(1):97-100. 6. Koch H, et al. Correlation of function and energy metabolism in rat ischemic skeletal muscle by 31P-NMR spectroscopy: effects of torbafylline. J Med. 1993;24(1):47-66.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Cancer Active Compound Library Membrane Protein-targeted Compound Library Kinase Inhibitor Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library Anti-Obesity Compound Library

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Keywords

Torbafylline 105102-21-4 GPCR/G Protein Metabolism PI3K/Akt/mTOR signaling PI3K cAMP PDE inhibitor inhibit

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