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SR-3-65
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Catalog No. T209392
SR-3-65 (compound 6) is an Indisulam derivative that inhibits the migration of gastric cancer cells by weakening the PI3K/AKT/GSK-3β/β-catenin signaling pathway.
SR-3-65
SR-3-65
😃Good
Catalog No. T209392
SR-3-65 (compound 6) is an Indisulam derivative that inhibits the migration of gastric cancer cells by weakening the PI3K/AKT/GSK-3β/β-catenin signaling pathway.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | SR-3-65 (compound 6) is an Indisulam derivative that inhibits the migration of gastric cancer cells by weakening the PI3K/AKT/GSK-3β/β-catenin signaling pathway. |
| In vitro | SR-3-65 effectively inhibits the growth of AGS cells with an IC₅₀ value of 24.75 μM when administered at concentrations ranging from 0.0001-100 µM over a 48-hour period. Additionally, SR-3-65 at 10 µM demonstrates anti-migratory activity in AGS and MGC803 cells over 48-72 hours. Furthermore, in AGS and MGC803 cells treated with 10 µM SR-3-65 for 48 hours, there is an upregulation of E-cadherin and a downregulation of N-cadherin and vimentin expression. |
| Formula | C16H9ClF3N3O2S |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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