21deoxycortisol

21-Deoxycortisol is a corticosteroid metabolite derived from the adrenal glands, produced by the 11β-hydroxylation of 17α-hydroxyprogesterone. Because it lacks a hydroxyl group at the 21st position, it cannot be further converted into cortisol through normal metabolic pathways. 21-Deoxycortisol is a key biomarker and clinical diagnostic marker for congenital adrenal hyperplasia (CAH); measuring its levels aids in disease screening, diagnosis, and treatment monitoring. As a C11-oxo C21 steroid, 21-deoxycortisol may participate in the “backdoor” pathway of steroid metabolism and is associated with the formation of 11-oxoandrogens and the hyperandrogenic state seen in CAH; therefore, it is also frequently used in research on steroid metabolism and endocrine regulation.

21-Deoxycortisol-D8 isol-D8 is a deuterated compound of 21-Deoxycortisol. 21-Deoxycortisol (T36915) has a CAS number of 641-77-0. 21-Deoxycortisol (T36915) is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.

21-Deoxycortisol (Standard) is a reference standard for research and analysis in studies involving 21-Deoxycortisol. 21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.

21-Deoxycortisol-[13C3] (Standard) is a reference standard of 21-Deoxycortisol-[13C3] intended for quantitative analysis, quality control, and related biochemical research applications.

21-Deoxycortisol-D8 (Standard) is a reference standard of 21-Deoxycortisol-D8 intended for quantitative analysis, quality control, and related biochemical research applications. 21-Deoxycortisol-d8 is a deuterated compound of 21-Deoxycortisol. 21-Deoxycortisol has a CAS number of 641-77-0. 21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.